A model for compound action potentials and currents in a nerve bundle III: A comparison of the conduction velocity distributions calculated from compound action currents and potentials

1991 ◽  
Vol 19 (1) ◽  
pp. 97-121 ◽  
Author(s):  
Ranjith S. Wijesinghe ◽  
Frans L. H. Gielen ◽  
John P. Wikswo
Keyword(s):  
Conduction Velocity ◽  
Action Potentials ◽  
Nerve Bundle ◽  
Compound Action Potentials ◽  
Conduction Velocity Distributions ◽  
Compound Action

Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots

1989 ◽  
Vol 67 (6) ◽  
pp. 682-685 ◽  
Author(s):  
S. Liske ◽  
M. E. Morris
Keyword(s):  
Action Potentials ◽  
Dorsal Root ◽  
Ventral Root ◽  
Aminobutyric Acid ◽  
Nerve Bundle ◽  
Myelinated Axons ◽  
Root Sheath ◽  
Compound Action Potentials ◽  
Spinal Roots ◽  
Compound Action

The effects of direct applications of GABA (γ-aminobutyric acid) and the GABAA agonist, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) on the excitability of myelinated axons of individual dorsal and ventral spinal roots (lumbar VI and (or) VII) of the isolated bullfrog peripheral nerve are reported. Increases evoked by the GABA agonists (0.01–10 mM) in the amplitude of half-maximal A-fiber compound action potentials indicate the presence of depolarizing responses with apparently greater localization to the dorsal roots, and a sensitivity to GABA twofold greater than that for THIP. The changes evoked by GABA and THIP, as well as potassium have components that closely resemble those of sensory and motor fibers in the more distal, desheathed nerve bundle but are smaller and delayed, differences attributable to a closely attached root sheath that acts as a diffusion barrier. These results confirm the likely existence of GABAA receptors on both dorsal and ventral spinal roots.Key words: GABAA receptors, dorsal root fibers, ventral root fibers, depolarization, hyperpolarization.

scholarly journals The Ionic Basis of Axonal Conduction in the Central Nervous System of Anodonta Cygnea (Mollusca: Eulamellibranchia)

1969 ◽  
Vol 50 (3) ◽  
pp. 711-722
Author(s):  
J. E. TREHERNE ◽  
DEFOREST MELLON ◽  
ALBERT D. CARLSON
Keyword(s):  
Conduction Velocity ◽  
Action Potentials ◽  
Slow Component ◽  
Compound Action Potential ◽  
Loss Of Function ◽  
Action Current ◽  
Bathing Medium ◽  
Anodonta Cygnea ◽  
Compound Action Potentials ◽  
Compound Action

The compound action potentials recorded in cerebro-visceral connectives consisted of a large homogeneous slow component, with a conduction velocity of between 0·03 and 0·04 m.sec-1, together with a variable rapidly conducting component, showing spikes with maximum velocities in the region of 0·4-0·5 m.sec-1. 2. Comparison of the square of the conduction velocity, for the various components of the compound action potential, with distribution of axon diameters in the connective showed that the small axons (0·1-0·3µ in diameter) contributed to the slow component, the larger axons (2·0-6·0 µ in diameter) forming the initial rapidly conducting spikes. 3. The small axons showed a rapid loss of function in preparations bathed in isotonic sucrose solutions. The larger axons, however, continued to function for appreciable periods in isotonic solutions of non-electrolytes. 4. The larger axons were rapidly and reversibly blocked by dilute tetrodotoxin. Additional evidence is also presented which suggests that the action potentials associated with the axons are sodium-dependent and do not depend upon any appreciable involvement of calcium ions in carrying the action current. 5. Both the large and the small axons appear to be relatively accessible to small ions and molecules in the bathing medium. The results are discussed in relation to the possible physiological mechanisms involved in the function of the larger axons in sodium-free solutions.

Stretch of mammalian nerve in vitro: Effect on compound action potentials

2000 ◽  
Vol 5 (4) ◽  
pp. 227-235 ◽  
Author(s):  
Sidney Ochs ◽  
Rahman Pourmand ◽  
Kenan Si ◽  
Richard N. Friedman
Keyword(s):  
Action Potentials ◽  
Compound Action Potentials ◽  
Vitro Effect ◽  
Mammalian Nerve ◽  
Compound Action

scholarly journals Site of cochlear stimulation and its effect on electrically evoked compound action potentials using the MED-EL standard electrode array

2009 ◽  
Vol 8 (1) ◽  
pp. 40 ◽  
Author(s):  
Stefan Brill ◽  
Joachim Müller ◽  
Rudolf Hagen ◽  
Alexander Möltner ◽  
Steffi-Johanna Brockmeier ◽  
...  
Keyword(s):  
Action Potentials ◽  
Electrode Array ◽  
Compound Action Potentials ◽  
Compound Action
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