Free-radical-induced mutation vs redox regulation: Costs and benefits of genes in organelles

1996 ◽  
Vol 42 (5) ◽  
pp. 482-492 ◽  
Author(s):  
John F. Allen ◽  
John A. Raven
Keyword(s):  
Free Radical ◽  
Redox Regulation ◽  
Costs And Benefits ◽  
Induced Mutation ◽  
Regulation Costs

scholarly journals Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease

Molecules ◽  
2012 ◽  
Vol 17 (10) ◽  
pp. 11391-11420 ◽  
Author(s):  
Sushruta Koppula ◽  
Hemant Kumar ◽  
Sandeep Vasant More ◽  
Hyung-Woo Lim ◽  
Soon-Min Hong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Free Radical ◽  
Redox Regulation ◽  
Radical Scavenging ◽  
Experimental Models ◽  
Free Radical Scavenging ◽  
Herbal Products

A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice

2007 ◽  
Vol 293 (4) ◽  
pp. H2508-H2515 ◽  
Author(s):  
Marie-Ève Gendron ◽  
Eric Thorin
Keyword(s):  
Free Radical ◽  
Endothelial Dysfunction ◽  
Mrna Expression ◽  
Redox Regulation ◽  
Enos Mrna ◽  
Synthase Inhibitor ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Old Mice ◽  
Cox 1

We reported that the endothelial dysfunction that develops with age was associated with a proinflammatory phenotype. In this study, we hypothesized that an increased production of proinflammatory cyclooxygenase (COX) products occurs before endothelial dysfunction. Dilations to acetylcholine (ACh) were recorded from pressurized renal arteries isolated from 3- and 6-mo-old C57Bl/6 male mice treated or not with the polyphenol catechin (30 mg·kg−1·day−1) in drinking water for 3 mo. Release of thromboxane (TX) B2, the metabolite of TXA2, was measured by using immunoenzymatic assays, and free radical production was measured by using the fluorescent dye CM-H2DCFDA. Endothelial nitric oxide synthase (eNOS) and COX-1/2 mRNA expression were quantified by quantitative PCR. NG-nitro-l-arginine (l-NNA) reduced ( P < 0.05) ACh-induced dilation in vessels isolated from 3- and 6-mo-old mice. In the presence of l-NNA, indomethacin normalized ( P < 0.05) the dilation in vessels from 6-mo-old mice only. SQ-29548 (PGH2/TXA2 receptor antagonist) and furegrelate (TXA2 synthase inhibitor), in the presence of l-NNA, also improved ( P < 0.05) dilation. l-NNA increased TXA2 release and free radical-associated fluorescence, the latter being prevented by SQ-29548. In vessels from 6-mo-old mice treated with catechin for 3 mo, l-NNA-dependent reduction in ACh-mediated dilation was insensitive to indomethacin, whereas TXA2 release and free radical-associated fluorescence were prevented. eNOS mRNA expression was significantly increased by catechin treatment. Our results suggest that an augmented production of TXA2 and the associated change in redox regulation precede the development of the endothelial dysfunction.

Using the research on intergroup conflict in nonhuman animals to help inform patterns of human intergroup conflict

2019 ◽  
Vol 42 ◽  
Author(s):  
Amanda R. Ridley ◽  
Melanie O. Mirville
Keyword(s):  
Large Body ◽  
Nonhuman Animal ◽  
Intergroup Conflict ◽  
Costs And Benefits ◽  
Animal Groups ◽  
Interesting Article ◽  
Nonhuman Animals

Abstract There is a large body of research on conflict in nonhuman animal groups that measures the costs and benefits of intergroup conflict, and we suggest that much of this evidence is missing from De Dreu and Gross's interesting article. It is a shame this work has been missed, because it provides evidence for interesting ideas put forward in the article.

Potentiation of bromotrichloromethane hepatotoxicity in male rats exposed to 10 ppm dietary chlordecone: Electron Microscopic and biochemical study

1990 ◽  
Vol 48 (3) ◽  
pp. 284-285
Author(s):  
O. M. Faroon ◽  
R. W. Henry ◽  
M. G. Soni ◽  
H. M. Mehendale
Keyword(s):  
Free Radical ◽  
Biochemical Study ◽  
Prior Exposure ◽  
Male Rats ◽  
Cellular Injury ◽  
Low Doses ◽  
Mixed Function Oxidase ◽  
Electron Microscopic ◽  
Potent Inducer ◽  
Cellular Energy

Previous work has shown that mirex undergoes photolytic dechlorination to chlordecone (CD) (KeponeR) in the environment. Much work has shown that prior exposure to nontoxic levels of CD causes potentiation of hepatotoxicity and lethality of CCl4, BrCCl3 and other halomethane compounds. Potentiation of bromotrichloromethane hepatotoxicity has been associated with compounds that stimulate the activity of hepatic mixed-function oxidase (MFO). An increase in the metabolism of halomethane by the MFO to a free radical initiates peroxidative decomposition of membranal lipids ending in massive cellular injury. However, not all MFO inducers potentiate BrCCl3 hepatotoxicity. Potentiation by much larger doses of phenobarbital is minimal and th at by a more potent inducer of MFO, mirex, is negligible at low doses. We suggest that the CD and bromotrichloromethane interaction results in a depletion of cellular energy and thereby reducing the cellular ability to undergo mitosis.

Deaminative carbonylative thioesterification of activated alkylamines with thiophenols under transition-metal-free conditions

2021 ◽  
Author(s):  
Fengqian Zhao ◽  
Xiao-Feng Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Metal Free

A transition-metal-free radical carbonylation of activated alkylamines with thiophenols has been successfully developed. Various thioesters were selectively produced with moderate to good yields.

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