scholarly journals Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease

Molecules ◽  
2012 ◽  
Vol 17 (10) ◽  
pp. 11391-11420 ◽  
Author(s):  
Sushruta Koppula ◽  
Hemant Kumar ◽  
Sandeep Vasant More ◽  
Hyung-Woo Lim ◽  
Soon-Min Hong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Free Radical ◽  
Redox Regulation ◽  
Radical Scavenging ◽  
Experimental Models ◽  
Free Radical Scavenging ◽  
Herbal Products

Free radical scavenging and hepatoprotective activity of HD-03/ES in experimental models

2012 ◽  
Vol 2 (2) ◽  
pp. 161 ◽  
Author(s):  
Suryakanth Anturlikar ◽  
Mohamed Rafiq ◽  
Mohammed Azeemuddin ◽  
Gollapalle Viswanatha ◽  
Mahalingaiah Jagadeesh ◽  
...  
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Hepatoprotective Activity ◽  
Experimental Models ◽  
Free Radical Scavenging

scholarly journals Antioxidant Therapy in Parkinson's Disease

1987 ◽  
Vol 14 (S3) ◽  
pp. 483-487 ◽  
Author(s):  
J. David Grimes ◽  
Mohamed N. Hassan ◽  
Jay Thakar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Free Radical ◽  
Monoamine Oxidase ◽  
Scientific Evidence ◽  
Radical Scavenging ◽  
Scientific Data ◽  
Antioxidant Therapy ◽  
Monoamine Oxidase B ◽  
High Dose

ABSTRACT:It is postulated that endogenous oxidative mechanisms are a major factor in the continuing death of dopaminergic neurons and the progression of Parkinson's disease. Scientific evidence in support of, and negating, the free radical auto-toxicity and dopamine toxicity concepts is reviewed. There is conflicting evidence whether free radicals are involved in the toxicity of l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and attempts to prevent the toxicity of MPTP with antioxidant therapy have had variable results. The oxidation of dopamine by monoamine oxidase produces toxic metabolites however animal studies with high dose longterm levodopa and MPTP have failed to show clear evidence for autoxidation. Firm supportive evidence is obtained from the monoamine oxidase B inhibitor experience which demonstrated a block of the toxicity of MPTP in animals and probable prolongation of the course of human Parkinson's disease.The scientific data available is inconclusive but there is significant hope of retarding progressive catecholaminergic neuron degenerative changes by augmenting the free radical scavenging system with antioxidants (such as Vitamin E) and slowing catecholamine oxidation by monoamine oxidase B inhibition. Careful clinical trials with these agents must be performed.

WHO Guidelines in Practice in India: Stability Studies on Selected CNS Active Herbal Products Through Physicochemical, Chromatographic and Biological Evaluations

2020 ◽  
Vol 6 (4) ◽  
pp. 360-379
Author(s):  
Nancy ◽  
Jasmeen Kaur ◽  
Yogita Bansal ◽  
Gulshan Bansal
Keyword(s):  
Free Radical ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Asiatic Acid ◽  
Stability Studies ◽  
Herbal Products ◽  
Long Term Stability ◽  
Control Samples

Background & Objective:: Accelerated stability study (40°C/75% RH, 6 months) as well as long term stability studies (30°C/65% RH, 36 months) are conducted on three batches (I-III) of two commercially available CNS active herbal products (A and B) containing Convolvulus pluricaulis with Centella asiatica or Bacopa monnieri. Methods:: Stability samples were withdrawn at periodic intervals, and evaluated for physical stability (color, clarity, viscosity and pH), chemical stability (total phenolic (TPC), scopoletin, asiatic acid and bacoside A content), and biological activities (free radical scavenging, anti-acetylcholinesterase, and antianxiety). All stability samples retained the physical characteristics compared to corresponding control samples. Control samples exhibited significant batch-to-batch variation in TPC (46.8-65.9 mgGAE/L), scopoletin (165.78-206.15 ng/mL in A and 2.61-28.78 ng/mL in B), asiatic acid (30.14-44.92 μg/mL in B), free radical scavenging activity (IC50 0.5-1.25% v/v), AChE inhibitory activity (IC50 75.0-96.3% v/v), and antianxiety activity. Results:: The chemical indicators and biological activities were significantly decreased in both accelerated and long term stability samples compared to corresponding control samples. A correlation between scopoletin and biological activities was established in products A whereas asiatic acid/C. asiatica defies the logical correlation in product B. Conclusion:: The products exhibited significant batch-to-batch variation, and did not remain stable for the recommended shelf life period of three years, which suggested that these are suspected to lose therapeutic efficacy during their shelf life.

scholarly journals On valorization of solvent extracts of Terminalia arjuna (arjuna) upon DNA scission and free radical scavenging improves coupling responses and cognitive functions under in vitro conditions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
D. K. Meena ◽  
A. K. Sahoo ◽  
P. P. Srivastava ◽  
N. P. Sahu ◽  
M. Jadhav ◽  
...  
Keyword(s):  
Free Radical ◽  
Gallic Acid ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Terminalia Arjuna ◽  
Herbal Products ◽  
Antioxidant Power ◽  
Ethnomedicinal Plant ◽  
Dna Nicking

AbstractChronic diseases have been treated using the phytochemical concepts of ethnomedicinal plant-derived herbal products. Terminalia arjuna, a significant ethnomedicinal plant, was revisited and reconnoitred for antioxidant, free radical scavenging, and DNA nicking inhibiting activity under H2O2 conditions using 21 solvent extracts. Ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid, and nitrous oxide scavenging (%) were found to have a strong positive association and interaction (PCA 1 explains 84.54% variation) with ethanol bark (Etoh-AB) (Meoh-AF). TPC (144.67–1794 µg/mL GAE) and TFC (2.5–34 µM Fe(II)/g were highest in Etoh-AB. In a pattern of combined solvent extracts, Etoh-AB had the highest antioxidant capacity, accompanied by Etoh-AL ≥ Meoh-AB ≥ Dw-AF. With R2 = 0.94, the DNA nicking inhibition behaviour parameters relative front, relative quantity, band (%), and lane (%) formed a positive significant (p < 0.01) connection. For the first time, we show that Etoh-AB nicks supercoiled, circular plasmid DNA in a way that is comparable to normal antioxidants. Normal antioxidants with the ability to prevent DNA nicking include Butylated hydroxy anisole < Butylated hydroxy toluene < ascorbic acid < and Gallic acid. Gallic acid (m/z 170.0208 g/mol) and Ellagic acid (m/z 302.0063 g/mol were present in high concentrations in solvent extracts. 0.48 mg was found to be the effective concentration for inhibiting relative DNA nicking. The current study is the first of its kind to show that steroid concentrations are higher in bark fractions of acetone, ethanol, and methanol. Furthermore, T. arjuna solvent extracts provide a wealth of information on phytochemical profiling, antioxidant ability, and DNA nicking inhibition, which may be useful for exploring the natural way and further research to develop a remedy against geriatric chronic disease. Despite the fact that ethanol is very close to methanol in terms of solvent toxicity, the current study identified it as the preferred solvent. Thus, the current research revisits previous studies and explores the potentiality of non-polar and polar aprotic and polar protic solvent systems, which lend credence to bioactive compounds that may be useful in isolating and formulating safe and cost effective herbal medicament for livestocks and aquaculture, and drugs for deoxygenerative human diseases, and can also be investigated further to instil environmental frugality.

scholarly journals Comparative Study of the in vitro Bioactivities of Bupleurum rigidum and B. fruticescens

2012 ◽  
Vol 7 (6) ◽  
pp. 1934578X1200700
Author(s):  
Jose M. Prieto ◽  
Makanjuola O. Ogunsina ◽  
Andrea Novak ◽  
Amit Joshi ◽  
Judit Kokai ◽  
...  
Keyword(s):  
Free Radical ◽  
Comparative Study ◽  
Radical Scavenging ◽  
Experimental Models ◽  
Free Radical Scavenging ◽  
Significant Activity ◽  
Aerial Parts ◽  
Melanoma B16f10 ◽  
Phytochemical Profile

Decoctions of the aerial parts of either Bupleurum rigidum or B. fruticescens are equally used in certain parts of Spain for the treatment of topical and musculoskeletal inflammations. In the present paper, their phytochemical profile and pharmacological value has been compared. After chromatographic and spectral analyses we could establish the presence of rutin and absence of chlorogenic acid in B. fruticescens, whilst the contrary applies to B. rigidum, providing a means to chemically differentiate extracts and dry materials from the two species. Their free radical scavenging and antiperoxidative activities were similar, with B. fruticescens being more active overall. The infusions of both Bupleurum species also showed similar anti-inflammatory activity when tested by NF-κB assay (40% and 42% at 60 μg·mL−1), as well as in a hexosaminidase exocytosis assay (30% at 50 μg·mL−1). Antimigratory effects on rat melanoma B16F10 showed significant activity for both infusions, with B. rigidum twice as potent as B. fruticescens, the activity of the latter not being fully explained by its content of rutin. Taking all these results together, we can conclude that, in the selected experimental models, there exist an in vitro bioequivalence of the infusions from both species, which is in agreement with the majority of ethnopharmacological reports.

scholarly journals Nephroprotection of Withania somnifera root extract against gentamicin induced nephrotoxicity: a histological evaluation in experimental Wistar rats

2019 ◽  
Vol 8 (10) ◽  
pp. 2297 ◽  
Author(s):  
Vimlesh Kushwaha
Keyword(s):  
Free Radical ◽  
Normal Saline ◽  
Withania Somnifera ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Histological Evaluation ◽  
Root Extract ◽  
Test Duration ◽  
Herbal Products ◽  
Once Daily

Background: Gentamicin, an aminoglycoside group of drug, used against aerobic gram negative bacteria, is known for nephrotoxicity. Herbal products have a special place in the world of pharmaceuticals with their safety, efficacy and cost effectiveness. Withania somnifera (Ashwagandha) roots had known since long for its antioxidant status and free radical scavenging property. So W. somnifera can be used as nephroprotective agent because of free radical scavenging property.Methods: Total 54 rats were randomised in 3 groups named G10, G20 and G30 according to 10, 20 and 30 days of treatment. In each groups, rats were randomly assigned to any of the three subgroups i.e., control C group [received normal saline (2 ml/100 gm/day) orally consecutively for test duration], gentamicin treated GT group [received normal saline (2 ml/100 gm/day) orally consecutively for test duration and intraperitoneal gentamicin (40 mg/kg) once daily for last five days] and W. somnifera treated WST group [received W. somnifera orally (500 mg/kg/day) for the test duration and intraperitoneal gentamicin (40 mg/kg) once daily for last five days]. Rats were sacrificed 24 hours after the last dose of gentamicin injection. Excised kidneys were weighted and prepared for histological examination.Results: The mean weight of kidneys in GT group was significantly higher than the WST group in all test durations indicating the antioxidant and free radical scavenging property. This was also reflected histologically as WST group kidney showed less amount inflammation as compared to GT group.Conclusions: W. somnifera root extract provide nephroprotection against gentamicin induced nephrotoxicity. 

Anti-inflammatory effects and anti-oxidant capacity of Myrathius arboreus (Cecropiaceae) in experimental models

2017 ◽  
Vol 28 (6) ◽  
Author(s):  
Oluwafemi Gabriel Oluwole ◽  
Olufunmilayo Ologe ◽  
Akinyinka Alabi ◽  
Ganiyu Tunde Yusuf ◽  
Solomon Umukoro
Keyword(s):  
Free Radical ◽  
Translational Medicine ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Experimental Models ◽  
Free Radical Scavenging ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Free Radical Scavenging Activities

AbstractBackground:Inflammation is involved in various diseases; search for safe treatments is warranted. Anti-inflammatory effects of ethanol extract ofMethods:In the carrageenan model EEMa (125, 250, or 500 mg/kg), indomethacin (5 mg/kg), or vehicle 3 mL/kg was administered orally in rats (Results:EEMa (250, 500 mg/kg) produced significant (p<0.001; p<0.05) inhibition of inflammation when compared with vehicle. Also, EEMa (250, 500, or 1000 μg/mL) significantly stabilized membrane and produced free radical scavenging activities.Conclusions:possesses anti-inflammatory and the anti-oxidant properties that might benefit translational medicine.

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