Clinicopathological study of myocardial infarction with normal or nearly normal extracardiac coronary arteries. Quantitative analysis of contraction band necrosis, coagulation necrosis, hemorrhage, and infarct size

1990 ◽  
Vol 6 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Der-Jinn Wu ◽  
Hisayoshi Fujiwara ◽  
Mitsuo Matsuda ◽  
Moriharu Ishida ◽  
Atsushi Kawamura ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Quantitative Analysis ◽  
Infarct Size ◽  
Coronary Arteries ◽  
Coagulation Necrosis ◽  
Contraction Band Necrosis ◽  
Clinicopathological Study ◽  
Contraction Band

Prevalence, determinants, and correlates of coagulation necrosis and contraction band necrosis in donor hearts

2019 ◽  
Vol 33 (2) ◽  
pp. e13472 ◽  
Author(s):  
Maya Guglin ◽  
Hesham R. Omar ◽  
Gregory Ray ◽  
Charles Wright
Keyword(s):  
Coagulation Necrosis ◽  
Contraction Band Necrosis ◽  
Contraction Band

scholarly journals Quantitative analysis of contraction band and coagulation necrosis after ischemia and reperfusion in the porcine heart.

Circulation ◽  
1987 ◽  
Vol 75 (5) ◽  
pp. 1074-1082 ◽  
Author(s):  
S Miyazaki ◽  
H Fujiwara ◽  
T Onodera ◽  
Y Kihara ◽  
M Matsuda ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Coagulation Necrosis ◽  
Ischemia And Reperfusion ◽  
Porcine Heart ◽  
Contraction Band

scholarly journals Heart and Brain: A Case of Focal Myocytolysis in Severe Pneumococcal Meningoencephalitis with Review of the Contemporary Literature

2003 ◽  
Vol 31 (2) ◽  
pp. 202-207 ◽  
Author(s):  
L. Brander ◽  
D. Weinberger ◽  
C. Henzen
Keyword(s):  
Myocardial Infarction ◽  
Brain Injuries ◽  
Myocardial Dysfunction ◽  
Contemporary Literature ◽  
Organ Donors ◽  
Related Factors ◽  
Contraction Band Necrosis ◽  
Head Injured ◽  
Electrocardiographic Changes ◽  
Contraction Band

We report electrocardiographic changes mimicking myocardial ischaemia in a 73-year-old man with fatal pneumococcal meningoencephalitis, present the autopsy-confirmed histological picture of extensive focal myocytolysis (contraction band necrosis) without myocardial infarction or myocarditis, and review the contemporary literature. Potentially reversible, probably non-ischaemic myocardial dysfunction may occur in association with acute noncardiac illnesses, such as brain injuries. Biochemical and morphological abnormalities in acutely failing hearts from head-injured organ donors point to specific pathophysiological mechanisms, which are different from heart failure from other causes. Sepsis-related factors may add to the myocardial dysfunction in patients with brain injury from meningoencephalitis.

Preinfarction Angina and Improved Reperfusion of the Infarct-related Artery

1999 ◽  
Vol 82 (S 01) ◽  
pp. 68-72 ◽  
Author(s):  
Alessandro Sciahbasi ◽  
Eugenia De Marco ◽  
Attilio Maseri ◽  
Felicita Andreotti
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Infarct Size ◽  
Ischemic Preconditioning ◽  
Early Reperfusion ◽  
Vast Number ◽  
Beneficial Effects ◽  
Infarct Related Artery ◽  
Cardioprotective Effects ◽  
Collateral Vessels

SummaryPreinfarction angina and early reperfusion of the infarct-related artery are major determinants of reduced infarct-size in patients with acute myocardial infarction. The beneficial effects of preinfarction angina on infarct size have been attributed to the development of collateral vessels and/or to post-ischemic myocardial protection. However, recently, a relation has been found between prodromal angina, faster coronary recanalization, and smaller infarcts in patients treated with rt-PA: those with preinfarction angina showed earlier reperfusion (p = 0.006) and a 50% reduction of CKMB-estimated infarct-size (p = 0.009) compared to patients without preinfarction angina. This intriguing observation is consistent with a subsequent observation of higher coronary recanalization rates following thrombolysis in patients with prodromal preinfarction angina compared to patients without antecedent angina. Recent findings in dogs show an enhanced spontaneous lysis of plateletrich coronary thrombi with ischemic preconditioning, which is prevented by adenosine blockade, suggesting an antithrom-botic effect of ischemic metabolites. Understanding the mechanisms responsible for earlier and enhanced coronary recanalization in patients with preinfarction angina may open the way to new reperfusion strategies.A vast number of studies, globally involving ≈17,000 patients with acute myocardial infarction, have unequivocally shown that an infarction preceded by angina evolves into a smaller area of necrosis compared to an infarct not preceded by angina (Table 1) (1). So far, preinfarction angina has been thought to have cardioprotective effects mainly through two mechanisms: collateral perfusion of the infarctzone (2-4), and ischemic preconditioning of the myocardium (5-7). Here we discuss a further mechanism of protection represented by improved reperfusion of the infarct-related artery.

Studies on the Functionality of Newly Synthesized Fibrinogen after Treatment of Acute Myocardial Infarction with Streptokinase, Increase in the Rate of Fibrinopeptide Release

1993 ◽  
Vol 70 (06) ◽  
pp. 0978-0983 ◽  
Author(s):  
Edelmiro Regano ◽  
Virtudes Vila ◽  
Justo Aznar ◽  
Victoria Lacueva ◽  
Vicenta Martinez ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Molecular Weight ◽  
Steady State ◽  
High Molecular Weight ◽  
Coronary Arteries ◽  
Risk Index ◽  
Weight Fraction ◽  
High Molecular Weight Fraction ◽  
Fibrinopeptide A

SummaryIn 15 patients with acute myocardial infarction who received 1,500,000 U of streptokinase, the gradual appearance of newly synthesized fibrinogen and the fibrinopeptide release during the first 35 h after SK treatment were evaluated. At 5 h the fibrinogen circulating in plasma was observed as the high molecular weight fraction (HMW-Fg). The concentration of HMW-Fg increased continuously, and at 20 h reached values higher than those obtained from normal plasma. HMW-Fg represented about 95% of the total fibrinogen during the first 35 h. The degree of phosphorylation of patient fibrinogen increased from 30% before treatment to 65% during the first 5 h, and then slowly declined to 50% at 35 h.The early rates of fibrinopeptide A (FPA) and phosphorylated fibrinopeptide A (FPAp) release are higher in patient fibrinogen than in isolated normal HMW-Fg and normal fibrinogen after thrombin addition. The early rate of fibrinopeptide B (FPB) release is the same for the three fibrinogen groups. However, the late rate of FPB release is higher in patient fibrinogen than in normal HMW-Fg and normal fibrinogen. Therefore, the newly synthesized fibrinogen clots faster than fibrinogen in the normal steady state.In two of the 15 patients who had occluded coronary arteries after SK treatment the HMW-Fg and FPAp levels increased as compared with the 13 patients who had patent coronary arteries.These results provide some support for the idea that an increased synthesis of fibrinogen in circulation may result in a procoagulant tendency. If this is so, the HMW-Fg and FPAp content may serve as a risk index for thrombosis.

Myocardial infarction with nonobstructed coronary arteries following accidental nitrogen inhalation

2019 ◽  
pp. 1
Author(s):  
Giulia Pontecorboli ◽  
Giulia Grazzini ◽  
Miroslava Stolcova ◽  
Linda Calistri ◽  
Manlio Acquafresca ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Arteries
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