Unstable mutations in neurological disease

1995 ◽  
Vol 242 (S2) ◽  
pp. S2-S3 ◽  
Keyword(s):  
Neurological Disease ◽  
Unstable Mutations

Investigating Neurological Disease

2001 ◽  
Author(s):  
Albert Hofman ◽  
Richard Mayeux
Keyword(s):  
Neurological Disease

scholarly journals The unmet needs of family members of patients with progressive neurological disease in the Czech Republic

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0214395 ◽  
Author(s):  
Radka Bužgová ◽  
Radka Kozáková ◽  
Lubica Juríčková
Keyword(s):  
Czech Republic ◽  
Neurological Disease ◽  
Unmet Needs ◽  
Family Members ◽  
The Czech Republic

scholarly journals The Aging Slow Wave: A Shifting Amalgam of Distinct Slow Wave and Spindle Coupling Subtypes Define Slow Wave Sleep Across the Human Lifespan

SLEEP ◽  
2021 ◽  
Author(s):  
Brice V McConnell ◽  
Eugene Kronberg ◽  
Peter D Teale ◽  
Stefan H Sillau ◽  
Grace M Fishback ◽  
...  
Keyword(s):  
Slow Wave ◽  
Neurological Disease ◽  
Mixed Model ◽  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Slow Waves ◽  
Cross Sectional ◽  
Relative Contribution ◽  
Human Lifespan ◽  
Development And Aging

Abstract Study Objectives Slow wave and spindle coupling supports memory consolidation, and loss of coupling is linked with cognitive decline and neurodegeneration. Coupling is proposed to be a possible biomarker of neurological disease, yet little is known about the different subtypes of coupling that normally occur throughout human development and aging. Here we identify distinct subtypes of spindles within slow wave upstates and describe their relationships with sleep stage across the human lifespan. Methods Coupling within a cross-sectional cohort of 582 subjects was quantified from stages N2 and N3 sleep across ages 6-88 years old. Results were analyzed across the study population via mixed model regression. Within a subset of subjects, we further utilized coupling to identify discrete subtypes of slow waves by their coupled spindles. Results Two different subtypes of spindles were identified during the upstates of (distinct) slow waves: an “early-fast” spindle, more common in stage N2 sleep, and a “late-fast” spindle, more common in stage N3. We further found stages N2 and N3 sleep contain a mixture of discrete subtypes of slow waves, each identified by their unique coupled-spindle timing and frequency. The relative contribution of coupling subtypes shifts across the human lifespan, and a deeper sleep phenotype prevails with increasing age. Conclusions Distinct subtypes of slow waves and coupled spindles form the composite of slow wave sleep. Our findings support a model of sleep-dependent synaptic regulation via discrete slow wave/spindle coupling subtypes and advance a conceptual framework for the development of coupling-based biomarkers in age-associated neurological disease.

Alleviation of Neurological Disease by RNA Editing

Methods ◽  
2021 ◽  
Author(s):  
Shaochong Zhang ◽  
Lu Chen ◽  
Yining Zhang ◽  
Dong Fang
Keyword(s):  
Rna Editing ◽  
Neurological Disease
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