The interaction of L-deprenyl and scopolamine on spatial learning/memory in rats

1993 ◽  
Vol 6 (3) ◽  
pp. 189-197 ◽  
Author(s):  
L. Yavich ◽  
J. Sirviö ◽  
E. Heinonen ◽  
P. Riekkinen
Keyword(s):  
Spatial Learning ◽  
Spatial Learning Memory

scholarly journals Effects of cochlear hair cell ablation on spatial learning/memory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Z. Jason Qian ◽  
Anthony J. Ricci
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Spatial Learning ◽  
Hair Cells ◽  
Noise Exposure ◽  
Memory Errors ◽  
Cochlear Hair Cells ◽  
Cochlear Hair Cell ◽  
Cell Ablation ◽  
Spatial Learning Memory

AbstractCurrent clinical interest lies in the relationship between hearing loss and cognitive impairment. Previous work demonstrated that noise exposure, a common cause of sensorineural hearing loss (SNHL), leads to cognitive impairments in mice. However, in noise-induced models, it is difficult to distinguish the effects of noise trauma from subsequent SNHL on central processes. Here, we use cochlear hair cell ablation to isolate the effects of SNHL. Cochlear hair cells were conditionally and selectively ablated in mature, transgenic mice where the human diphtheria toxin (DT) receptor was expressed behind the hair-cell specific Pou4f3 promoter. Due to higher Pou4f3 expression in cochlear hair cells than vestibular hair cells, administration of a low dose of DT caused profound SNHL without vestibular dysfunction and had no effect on wild-type (WT) littermates. Spatial learning/memory was assayed using an automated radial 8-arm maze (RAM), where mice were trained to find food rewards over a 14-day period. The number of working memory errors (WME) and reference memory errors (RME) per training day were recorded. All animals were injected with DT during P30–60 and underwent the RAM assay during P90–120. SNHL animals committed more WME and RME than WT animals, demonstrating that isolated SNHL affected cognitive function. Duration of SNHL (60 versus 90 days post DT injection) had no effect on RAM performance. However, younger age of acquired SNHL (DT on P30 versus P60) was associated with fewer WME. This describes the previously undocumented effect of isolated SNHL on cognitive processes that do not directly rely on auditory sensory input.

Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats

Neuroscience ◽  
2017 ◽  
Vol 344 ◽  
pp. 39-47 ◽  
Author(s):  
Rui Wang ◽  
Yu Zhang ◽  
Jianguo Li ◽  
Ce Zhang
Keyword(s):  
Spatial Learning ◽  
Memory Impairment ◽  
Spatial Learning Memory

scholarly journals Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation

2015 ◽  
Vol 8 ◽  
pp. JCD.S30596 ◽  
Author(s):  
Hui-Lin Wang ◽  
Rui-Hua Ma ◽  
Hao Fang ◽  
Zhang-Gang Xue ◽  
Qing-Wu Liao
Keyword(s):  
Elderly Patients ◽  
Spatial Learning ◽  
Postoperative Cognitive Dysfunction ◽  
Microglia Activation ◽  
Behavioral Deficits ◽  
Adult Mice ◽  
Tnf Α ◽  
Ifn Γ ◽  
Common Problems ◽  
Spatial Learning Memory

Postoperative cognitive dysfunction (POCD) has been one of the most common problems in elderly patients following surgery. But the specific mechanism of POCD is still not clear. To further understand the reason of these postoperative behavioral deficits, we evaluated the spatial learning memory of both adult (3 months) and aged (18 months) male mice, 3 or 28 days after isoflurane (Iso) exposure for two hours or appendectomy (App). Hippocampal microglia activation and IL-1β, TNF-α, and IFN-γ expression were also evaluated at day 3, day 14 and day 28 after Iso exposure or appendectomy. Results showed that spatial learning memory of aged, but not adult, mice was impaired after Iso exposure or appendectomy, accompanied with more hippocampal microglia activation and IL-1β, TNF-α, and IFN-γ overexpression. These findings suggest that the cognitive deficits of elderly patients who have undergone surgeries are quite possibly caused by hippocampal microglia overactivation and the subsequent inflammation.

scholarly journals Repeated Sleep Restriction in Adolescent Rats Altered Sleep Patterns and Impaired Spatial Learning/Memory Ability

SLEEP ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 849-859 ◽  
Author(s):  
Su-Rong Yang ◽  
Hui Sun ◽  
Zhi-Li Huang ◽  
Ming-Hui Yao ◽  
Wei-Min Qu
Keyword(s):  
Spatial Learning ◽  
Sleep Restriction ◽  
Sleep Patterns ◽  
Memory Ability ◽  
Adolescent Rats ◽  
Spatial Learning Memory

scholarly journals Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion

2021 ◽  
Vol 25 (Suppl 2) ◽  
pp. S72-80
Author(s):  
Jae-Min Lee ◽  
Jongmin Park ◽  
Joo-Hee Lee ◽  
Min Kyung Song ◽  
Youn-Jung Kim
Keyword(s):  
Cerebral Ischemia ◽  
Spatial Learning ◽  
Memory Impairment ◽  
Treadmill Exercise ◽  
Chronic Cerebral Hypoperfusion ◽  
Treadmill Running ◽  
Cerebral Hypoperfusion ◽  
Morris Water Maze Test ◽  
Sirt1 Expression ◽  
Spatial Learning Memory

Purpose: Silent information regulator 1 (SIRT1) in the brain is essential for maintaining cellular homeostasis and plays a neuroprotective role in cerebral ischemia and neurodegenerative disorders. The effect of preischemic treadmill exercise on chronic cerebral hypoperfusion (CCH)-induced spatial learning memory impairment, microvascular injury, and blood-brain barrier (BBB) disruption in relation with SIRT1 expression was evaluated.Methods: Prior to bilateral common carotid artery occlusion (BCCAO) surgery, the rats in the exercise groups performed low-intensity treadmill running for 30 minutes once daily during 8 weeks. BCCAO surgery was performed on male Wistar rats at 12 weeks of age. Spatial learning memory was measured using the Morris water maze test. Neuronal nuclear antigen, SIRT1, and rat endothelial cells antigen 1 were determined by immunohistochemistry and platelet-derived growth factor receptor beta was determined by immunofluorescence.Results: Preischemic treadmill exercise ameliorated spatial learning memory impairment and enhanced SIRT1 expression in the BCCAO rats. Preischemic treadmill exercise ameliorated BCCAO-induced damage to microvasculature and pericytes that make up the BBB. The effect of preischemic treadmill exercise was lost with sirtinol treatment.Conclusions: These results can apply treadmill exercise prior to cerebral ischemia as a rational preventive and therapeutic intervention strategy to improve cognitive dysfunction in CCH patients.

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