Effects of chronic stress on ability of spatial learning-memory and expression of brain-derived neurotrophic factor in mice

2010 ◽  
Vol 34 (8) ◽  
pp. S28-S28
Author(s):  
Ya Li ◽  
Yun Xu ◽  
Ya‑nan Zhang ◽  
Yu‑qi Wang
Keyword(s):  
Chronic Stress ◽  
Spatial Learning ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Spatial Learning Memory

scholarly journals Resilience to Chronic Stress Is Mediated by Hippocampal Brain-Derived Neurotrophic Factor

2011 ◽  
Vol 31 (12) ◽  
pp. 4475-4483 ◽  
Author(s):  
D. Taliaz ◽  
A. Loya ◽  
R. Gersner ◽  
S. Haramati ◽  
A. Chen ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals The role of dendritic brain-derived neurotrophic factor transcripts on altered inhibitory circuitry in depression

2018 ◽  
Author(s):  
Hyunjung Oh ◽  
Sean C. Piantadosi ◽  
Brad R. Rocco ◽  
David A. Lewis ◽  
Simon C. Watkins ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Stress ◽  
Pyramidal Cell ◽  
Neurotrophic Factor ◽  
Cortical Neurons ◽  
Pyramidal Neurons ◽  
Cell Structure ◽  
Brain Derived Neurotrophic Factor ◽  
Inhibitory Circuitry ◽  
Synaptic Markers

ABSTRACTBackgroundA parallel downregulation of brain-derived neurotrophic factor (BDNF) and somatostatin (SST), a marker of inhibitory γ-amino-butyric acid (GABA) interneurons which target pyramidal cell dendrites, has been reported in several brain areas of subjects with major depressive disorder (MDD), and rodent genetic studies suggests they are linked and both contribute to the illness. However, the mechanism by which they contribute to the pathophysiology of the illness has remained elusive.MethodsWith qPCR, we determined the expression level of BDNF transcript variants and synaptic markers in the prefrontal cortex (PFC) of MDD patients and matched controls (n=19/group) and of C57BL/6J mice exposed to chronic stress or control conditions (n=12/group). We next suppressed BDNF transcripts with long 3’ untranslated region (L-3’-UTR) using small hairpin RNA (shRNA) and investigated changes in cell morphology, gene expression and behavior.ResultsL-3’-UTR containing BDNF mRNAs, which migrate to distal dendrites of pyramidal neurons, are selectively reduced and highly correlated with SST expression in the PFC of MDD subjects. A similar downregulation occurs in mice submitted to chronic stress. We next show that Bdnf L-3’-UTR knockdown is sufficient to induce (i) dendritic shrinkage in cortical neurons, (ii) cell-specific MDD-like gene changes (including Sst downregulation), and (iii) depressive-/anxiety-like behaviors. The translational validity of the Bdnf L-3’-UTR shRNA-treated mice was confirmed by significant cross-species correlation of changes in MDD-associated gene expression.ConclusionThese findings provide evidence for a novel MDD-related pathological mechanism linking local neurotrophic support, pyramidal cell structure, dendritic inhibition and mood regulation.

Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin α5 expression in the rat pineal gland

2006 ◽  
Vol 1086 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Alexies Dagnino-Subiabre ◽  
Rodrigo Zepeda-Carreño ◽  
Gabriela Díaz-Véliz ◽  
Sergio Mora ◽  
Francisco Aboitiz
Keyword(s):  
Pineal Gland ◽  
Chronic Stress ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Mrna ◽  
Integrin Α5 ◽  
Rat Pineal Gland
Sign in / Sign up

Export Citation Format

Share Document