Inhibition of tumor cell growth by triton X-100 through specific effects on cell-cycle-regulatory components

2004 ◽  
Vol 11 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Esther R. Picache ◽  
Loubna Hassanieh ◽  
Daniel Broek ◽  
Axel H. Schönthal
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cell Growth ◽  
Specific Effects ◽  
Triton X

Synthesis of a Natural Chalcone and Its Prenyl Analogs - Evaluation of Tumor Cell Growth-Inhibitory Activities, and Effects on Cell Cycle and Apoptosis

2012 ◽  
Vol 9 (6) ◽  
pp. 1133-1143 ◽  
Author(s):  
Marta P. Neves ◽  
Raquel T. Lima ◽  
Kanthima Choosang ◽  
Panee Pakkong ◽  
Maria de São José Nascimento ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cell Growth ◽  
Growth Inhibitory ◽  
Inhibitory Activities

scholarly journals Inhibition of tumor cell growth by adenine is mediated by apoptosis induction and cell cycle S phase arrest

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94286-94296 ◽  
Author(s):  
Ming Han ◽  
Xin Cheng ◽  
Zhiqin Gao ◽  
Rongrong Zhao ◽  
Shizhuang Zhang
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
S Phase ◽  
Tumor Cell Growth ◽  
Apoptosis Induction ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Cell cycle genes as targets of retinoid induced ovarian tumor cell growth suppression

Oncogene ◽  
2001 ◽  
Vol 20 (55) ◽  
pp. 7935-7944 ◽  
Author(s):  
Dongmei Zhang ◽  
Scott Vuocolo ◽  
Valeria Masciullo ◽  
Teodoro Sava ◽  
Antonio Giordano ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Ovarian Tumor ◽  
Growth Suppression ◽  
Tumor Cell Growth ◽  
Cell Cycle Genes ◽  
Ovarian Tumor Cell ◽  
Cell Growth Suppression

scholarly journals L2DTL, a cell cycle regulated gene is essential to tumor cell growth

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Hung‐Wei Pan ◽  
Mei‐Ling Chen ◽  
Ray‐Hwang Yuan
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Tumor Cell Growth ◽  
A Cell

scholarly journals Shikonin Reduces Growth of Docetaxel-Resistant Prostate Cancer Cells Mainly through Necroptosis

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 882
Author(s):  
Sascha D. Markowitsch ◽  
Kira M. Juetter ◽  
Patricia Schupp ◽  
Kristine Hauschulte ◽  
Olesya Vakhrusheva ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Metabolic Activity ◽  
Treatment Options ◽  
Therapy Resistance ◽  
Tumor Cell Growth ◽  
Antitumor Effects ◽  
New Treatment ◽  
Induced Apoptosis

The prognosis for advanced prostate carcinoma (PCa) remains poor due to development of therapy resistance, and new treatment options are needed. Shikonin (SHI) from Traditional Chinese Medicine has induced antitumor effects in diverse tumor entities, but data related to PCa are scarce. Therefore, the parental (=sensitive) and docetaxel (DX)-resistant PCa cell lines, PC3, DU145, LNCaP, and 22Rv1 were exposed to SHI [0.1–1.5 μM], and tumor cell growth, proliferation, cell cycling, cell death (apoptosis, necrosis, and necroptosis), and metabolic activity were evaluated. Correspondingly, the expression of regulating proteins was assessed. Exposure to SHI time- and dose-dependently inhibited tumor cell growth and proliferation in parental and DX-resistant PCa cells, accompanied by cell cycle arrest in the G2/M or S phase and modulation of cell cycle regulating proteins. SHI induced apoptosis and more dominantly necroptosis in both parental and DX-resistant PCa cells. This was shown by enhanced pRIP1 and pRIP3 expression and returned growth if applying the necroptosis inhibitor necrostatin-1. No SHI-induced alteration in metabolic activity of the PCa cells was detected. The significant antitumor effects induced by SHI to parental and DX-resistant PCa cells make the addition of SHI to standard therapy a promising treatment strategy for patients with advanced PCa.

scholarly journals VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

Oncogene ◽  
2003 ◽  
Vol 22 (26) ◽  
pp. 4035-4046 ◽  
Author(s):  
Seung Hyun Han ◽  
Jun Ho Jeon ◽  
Hyang Ran Ju ◽  
Uhee Jung ◽  
Kun Young Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Cycle Progression ◽  
Tumor Cell Growth ◽  
Cycle Progression ◽  
Tgf Β1
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