Attenuation of scopolamine-induced spatial memory deficits in the rat by cholinomimetic and non-cholinomimetic drugs using a novel task in the 12-arm radial maze

1993 ◽  
Vol 111 (4) ◽  
pp. 435-441 ◽  
Author(s):  
Robert P. Dennes ◽  
Julie C. Barnes
Keyword(s):  
Spatial Memory ◽  
Radial Maze ◽  
Memory Deficits ◽  
Cholinomimetic Drugs

Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague–Dawley rats

2004 ◽  
Vol 151 (1-2) ◽  
pp. 287-293 ◽  
Author(s):  
Yu-Wen Huang ◽  
Wei-Wei Hu ◽  
Zhong Chen ◽  
Li-San Zhang ◽  
Hai-Qing Shen ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Radial Maze ◽  
Memory Deficits ◽  
Sprague Dawley ◽  
Mk 801 ◽  
Sprague Dawley Rats ◽  
Histamine H3

Intracerebral drug delivery in rats with lesion-induced memory deficits

1989 ◽  
Vol 71 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Matthew A. Howard ◽  
Alan Gross ◽  
M. Sean Grady ◽  
Robert S. Langer ◽  
Edith Mathiowitz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Spatial Memory ◽  
Radial Maze ◽  
Sebacic Acid ◽  
Performance Testing ◽  
Memory Deficits ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug

✓ Pharmacological treatments directed at increasing cortical acetylcholine activity in patients with Alzheimer's disease have largely been disappointing, perhaps because denervated areas of brain may not be exposed to adequate amounts of drug. A new method has been developed to enable localized intracerebral delivery of neurotransmitter substances using a polymeric drug delivery system. Microspheres of a polyanhydride sebacic acid copolymer were impregnated with bethanechol, an acetylcholinesterase-resistant cholinomimetic. Twenty rats received bilateral fimbria-fornix lesions, producing cholinergic denervation of the hippocampus and marked impairment in spatial memory. The animals were trained for 2 weeks to run an eight-arm radial maze, after which they received bilateral intrahippocampal implants of saline (five rats), blank polymer (five rats), or bethanechol-impregnated polymer (10 rats). Following implantation, spatial memory was assessed by radial-maze performance testing for 40 days. Untreated lesioned rats showed persistently poor spatial memory, entering maze arms with near random frequency. Similarly, animals treated with saline and blank polymer did not improve after implantation. Rats treated with bethanechol-impregnated microspheres, however, displayed significant improvement within 10 days after implantation; this improvement persisted for the duration of the experiment (p < 0.05, Student's t-test). Histological analysis of regional acetylcholinesterase staining showed widespread loss of activity throughout the hippocampus bilaterally in all animals. The microsphere implants were visible within the hippocampus, with minimal reactive changes in surrounding brain. It is concluded that intracerebral polymeric drug delivery successfully reversed lesion-induced memory deficits, and has potential as a neurosurgical treatment method for Alzheimer's disease and other neurodegenerative disorders.

scholarly journals Spatial memory deficits in a virtual reality eight-arm radial maze in schizophrenia

2012 ◽  
Vol 135 (1-3) ◽  
pp. 84-89 ◽  
Author(s):  
Elena A. Spieker ◽  
Robert S. Astur ◽  
Jeffrey T. West ◽  
Jacqueline A. Griego ◽  
Laura M. Rowland
Keyword(s):  
Virtual Reality ◽  
Spatial Memory ◽  
Radial Maze ◽  
Memory Deficits

“Subclinical” Dosages of Lithium and Pilocarpine that Do Not Evoke Overt Seizures Affect Long-Term Spatial Memory but Not Learning in Rats

1998 ◽  
Vol 86 (3_suppl) ◽  
pp. 1288-1290 ◽  
Author(s):  
L. L. Cook ◽  
M. A. Persinger
Keyword(s):  
Spatial Memory ◽  
Effect Size ◽  
Radial Maze ◽  
Reference Group ◽  
Memory Deficits ◽  
Male Rats ◽  
Learning Deficits ◽  
Two Delays

After training in an automated radial maze, 11 male rats were injected with either “subclinical” dosages of lithium and pilocarpine or saline and then tested 5 days or 4 months later. When employed as their own controls or when compared with a saline-injected reference group, the rats that had received the lithium and pilocarpine displayed memory deficits but not learning deficits after the longest of the two delays (effect size was 41%). These results suggest that subtle disruptions in memory but not learning to criterion could be associated with “subclinical electrical seizures” or the micromorphological changes associated with this activity.

Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice

2013 ◽  
Vol 34 (3) ◽  
pp. 716-730 ◽  
Author(s):  
Nour Yassine ◽  
Anelise Lazaris ◽  
Cornelia Dorner-Ciossek ◽  
Olivier Després ◽  
Laurence Meyer ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Deficits
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