Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats

1993 ◽  
Vol 110 (1-2) ◽  
pp. 140-144 ◽  
Author(s):  
Jean-Luc Moreau ◽  
François Jenck ◽  
James R. Martin ◽  
Sabine Perrin ◽  
Willy E. Haefely
Keyword(s):  
Behavioral Response ◽  
Receptor Activation ◽  
Mild Stress ◽  
Antidepressant Treatments

Modulation of the Nuclear Factor (Erythroid 2-Derived)-Like 2 Pathway by Antidepressants In Rats

2016 ◽  
Vol 33 (S1) ◽  
pp. S527-S527
Author(s):  
D. Martín Hernández ◽  
Á.G. Bris ◽  
K.S. MacDowell ◽  
A. Sayd ◽  
D. Azpiazu ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Nitrosative Stress ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Nuclear Factor ◽  
Nrf2 Pathway ◽  
Antidepressant Treatments ◽  
Male Wistar Rats ◽  
Competing Interest

IntroductionPatients with major depression who are otherwise medically healthy have activated inflammatory pathways. It has been described that depression is not only escorted by inflammation but also by induction of multiple oxidative/nitrosative stress pathways. Nevertheless, there are finely regulated mechanisms involved in preserving cells from damage, such as the nuclear factor Nrf2.AimsTo explore in a depression-like model the Nrf2 pathway in the prefrontal cortex (PFC) and the hippocampus of rats and to analyze which classic antidepressants affect the antioxidant activity of the Nrf2 pathway.MethodsMale Wistar rats were exposed to chronic mild stress (CMS) and some of them were treated with desipramine, escitalopram or duloxetine. We studied the expression in the PFC and hippocampus of upstream and downstream elements of the Nrf2 pathway and the oxidative damage induced by the CMS.ResultsAfter exposure to a CMS protocol, in the PFC, there is an inhibition of upstream and downstream elements of the Nrf2 pathway. Moreover, antidepressant treatments, particularly desipramine and duloxetine, are able to recover some of these elements and to reduce the oxidative damage induced by the depression model. In the hippocampus however, Nrf2 pathways are not that affected and antidepressants do not have many actions.ConclusionsNrf2 pathway is differentially regulated by antidepressants in the PFC and hippocampus. The Nrf2 pathway is involved in the oxidative/nitrosative damage detected in the PFC after CMS exposure. However, it seems that Nrf2 is not very involved in the effects caused by the CMS in the hippocampus.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Chronic neonatal mild stress induces long lasting alterations on peripheral nervous system programming in mice

2004 ◽  
Author(s):  
G. Galietta ◽  
A. Capasso ◽  
A. Fortuna ◽  
F. Fabi ◽  
P. Del Basso ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Mild Stress ◽  
System Programming
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