scholarly journals Cannabinoid Receptor Activation Prevents the Effects of Chronic Mild Stress on Emotional Learning and LTP in a Rat Model of Depression

2013 ◽  
Vol 39 (4) ◽  
pp. 919-933 ◽  
Author(s):  
Amir Segev ◽  
Adva S Rubin ◽  
Hila Abush ◽  
Gal Richter-Levin ◽  
Irit Akirav
Keyword(s):  
Rat Model ◽  
Cannabinoid Receptor ◽  
Chronic Mild Stress ◽  
Receptor Activation ◽  
Emotional Learning ◽  
Mild Stress

Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression

1993 ◽  
Vol 54 (6) ◽  
pp. 1215-1220 ◽  
Author(s):  
Olgierd Pucilowski ◽  
David H Overstreet ◽  
Amir H Rezvani ◽  
David S Janowsky
Keyword(s):  
Rat Model ◽  
Chronic Mild Stress ◽  
Mild Stress

scholarly journals Hippocampal Cytogenesis Correlates to Escitalopram-Mediated Recovery in a Chronic Mild Stress Rat Model of Depression

2006 ◽  
Vol 31 (11) ◽  
pp. 2395-2404 ◽  
Author(s):  
Magdalena N Jayatissa ◽  
Christina Bisgaard ◽  
Anders Tingström ◽  
Mariusz Papp ◽  
Ove Wiborg
Keyword(s):  
Rat Model ◽  
Chronic Mild Stress ◽  
Mild Stress

scholarly journals Depressive-like States Heighten the Aversion to Painful Stimuli in a Rat Model of Comorbid Chronic Pain and Depression

2012 ◽  
Vol 117 (3) ◽  
pp. 613-625 ◽  
Author(s):  
Lidia Bravo ◽  
Juan Antonio Mico ◽  
Raquel Rey-Brea ◽  
Beatriz Pérez-Nievas ◽  
Juan Carlos Leza ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Anterior Cingulate Cortex ◽  
Rat Model ◽  
Chronic Mild Stress ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Mild Stress ◽  
Sham Control ◽  
Neuronal Density ◽  
Extracellular Signal

Background Chronic pain and depression are two complex states with sensory/somatic and emotional components, and they may mutually exacerbate one another in conditions of comorbidity, leading to a poorer prognosis. Methods The authors have evaluated the sensory and emotional components in a rat model combining chronic constriction injury (CCI, a model of chronic neuropathic pain) with unpredictable chronic mild stress (CMS, an experimental model of depression). In addition, the phosphorylation/activation of the extracellular signal-regulated kinases 1 and 2 and neuronal density was also evaluated in the anterior cingulate cortex. Four groups were tested: sham-control, sham-CMS, CCI-control, and CCI-CMS. Results CMS selectively heightens aversion to painful experiences in animals subjected to CCI, as measured in the place escape/avoidance test at 20, 25, and 30 min (CCI-CMS (mean±SEM): 75.68±3.32, 66.75±4.70, 77.54±3.60 vs. CCI-control: 44.66±6.07, 43.17±6.92, 52.83±5.92, respectively), in conjunction with an increase in the accumulation of phosphorylation/activation of the extracellular signal-regulated kinases (CCI-CMS: 4.17±0.52 vs. sham-control: 0.96±0.05) and a decrease in neuronal density in the anterior cingulate cortex. In contrast, chronic pain did not exacerbate the characteristic profile of depression (anhedonia and behavioral despair) in rats subjected to CMS. Furthermore, depression enhances the perception of some specific modalities of sensorial pain such as cold allodynia but has no influence on mechanical threshold. Conclusions These findings support the theory that depression leads to emotional dysfunction in the interpretation of pain in patients suffering chronic pain. In addition, combined animal models of pain-depression may provide a valuable tool to study the comorbidity of pain and depression.

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

2015 ◽  
Vol 292 ◽  
pp. 233-240 ◽  
Author(s):  
Tuğçe Demirtaş Şahin ◽  
Ayşe Karson ◽  
Fuat Balcı ◽  
Yusufhan Yazır ◽  
Dilek Bayramgürler ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Rat Model ◽  
Chronic Mild Stress ◽  
Tnf Alpha ◽  
Mild Stress ◽  
Unpredictable Chronic Mild Stress

Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression

2016 ◽  
Vol 110 ◽  
pp. 43-48 ◽  
Author(s):  
S.L. Christiansen ◽  
K. Højgaard ◽  
O. Wiborg ◽  
E.V. Bouzinova
Keyword(s):  
Rat Model ◽  
Diurnal Rhythm ◽  
Chronic Mild Stress ◽  
Mild Stress

Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression

2012 ◽  
Vol 23 (8) ◽  
pp. 735-743 ◽  
Author(s):  
Kim Henningsen ◽  
Mads Dyrvig ◽  
Elena V. Bouzinova ◽  
Sofie Christiansen ◽  
Trine Christensen ◽  
...  
Keyword(s):  
Rat Model ◽  
Maternal Care ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Susceptibility

Cognitive effects of the GSK-3 inhibitor “lithium” in LPS/chronic mild stress rat model of depression: Hippocampal and cortical neuroinflammation and tauopathy

2021 ◽  
Author(s):  
Mai A. Ebeid ◽  
Mohamed Z. Habib ◽  
Ahmed M. Mohamed ◽  
Yasser el Faramawy ◽  
Sherin S.T. Saad ◽  
...  
Keyword(s):  
Rat Model ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Cognitive Effects
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