Behavioural tests of the dopamine depletion hypothesis of neuroleptic-induced response decrement

1992 ◽  
Vol 106 (4) ◽  
pp. 543-549 ◽  
Author(s):  
Paul Willner ◽  
Gavin Phillips ◽  
Richard Muscat ◽  
Peter Hood
Keyword(s):  
Induced Response ◽  
Dopamine Depletion ◽  
Response Decrement ◽  
Behavioural Tests

Training to test interval as a determinant of a temporally graded ECS-produced response decrement in rats.

1970 ◽  
Vol 71 (2, Pt.1) ◽  
pp. 318-324 ◽  
Author(s):  
Richard A. Hughes ◽  
Robert J. Barrett ◽  
Oakley S. Ray
Keyword(s):  
Response Decrement ◽  
Test Interval

Substantia nigra hyperechogenicity and CSF dopamine depletion in HIV

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
J Thiermann ◽  
M Obermann ◽  
M Küper ◽  
O Kastrup ◽  
Ö Yaldizli ◽  
...  
Keyword(s):  
Substantia Nigra ◽  
Dopamine Depletion ◽  
Substantia Nigra Hyperechogenicity

Association of the Non-Motor Burden with Patterns of Striatal Dopamine Loss in de novo Parkinson’s Disease

2020 ◽  
Vol 10 (4) ◽  
pp. 1541-1549
Author(s):  
Seok Jong Chung ◽  
Sangwon Lee ◽  
Han Soo Yoo ◽  
Yang Hyun Lee ◽  
Hye Sun Lee ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
De Novo ◽  
Early Stage ◽  
Striatal Dopamine ◽  
Motor Deficits ◽  
Dopamine Depletion ◽  
Severe Motor ◽  
Severe Group ◽  
Striatal Dopamine Depletion

Background: Striatal dopamine deficits play a key role in the pathogenesis of Parkinson’s disease (PD), and several non-motor symptoms (NMSs) have a dopaminergic component. Objective: To investigate the association between early NMS burden and the patterns of striatal dopamine depletion in patients with de novo PD. Methods: We consecutively recruited 255 patients with drug-naïve early-stage PD who underwent 18F-FP-CIT PET scans. The NMS burden of each patient was assessed using the NMS Questionnaire (NMSQuest), and patients were divided into the mild NMS burden (PDNMS-mild) (NMSQuest score <6; n = 91) and severe NMS burden groups (PDNMS-severe) (NMSQuest score >9; n = 90). We compared the striatal dopamine transporter (DAT) activity between the groups. Results: Patients in the PDNMS-severe group had more severe parkinsonian motor signs than those in the PDNMS-mild group, despite comparable DAT activity in the posterior putamen. DAT activity was more severely depleted in the PDNMS-severe group in the caudate and anterior putamen compared to that in the PDMNS-mild group. The inter-sub-regional ratio of the associative/limbic striatum to the sensorimotor striatum was lower in the PDNMS-severe group, although this value itself lacked fair accuracy for distinguishing between the patients with different NMS burdens. Conclusion: This study demonstrated that PD patients with severe NMS burden exhibited severe motor deficits and relatively diffuse dopamine depletion throughout the striatum. These findings suggest that the level of NMS burden could be associated with distinct patterns of striatal dopamine depletion, which could possibly indicate the overall pathological burden in PD.

Wind Pressure and Wind-Induced Vibration of Heliostat

2008 ◽  
Vol 400-402 ◽  
pp. 935-940 ◽  
Author(s):  
Ying Ge Wang ◽  
Zheng Nong Li ◽  
Bo Gong ◽  
Qiu Sheng Li
Keyword(s):  
Dynamic Response ◽  
Wind Direction ◽  
Wind Load ◽  
Wind Pressure ◽  
Induced Response ◽  
Vertical Angle ◽  
Lateral Direction ◽  
Direction Angle ◽  
Wind Pressures ◽  
Fluctuating Wind

Heliostat is the key part of Solar Tower power station, which requires extremely high accuracy in use. But it’s sensitive to gust because of its light structure, so effect of wind load should be taken into account in design. Since structure of heliostat is unusual and different from common ones, experimental investigation on rigid heliostat model using technology of surface pressure mensuration to test 3-dimensional wind loads in wind tunnel was conducted. The paper illustrates distribution and characteristics of reflector’s mean and fluctuating wind pressure while wind direction angle varied from 0° to 180° and vertical angle varied from 0° to 90°. Moreover, a finite element model was constructed to perform calculation on wind-induced dynamic response. The results show that the wind load power spectral change rulers are influenced by longitudinal wind turbulence and vortex and are related with Strouhal number; the fluctuating wind pressures between face and back mainly appear positive correlation, and the correlation coefficients at longitudinal wind direction are smaller than those at lateral direction; the fluctuating wind pressures preferably agree with Gaussian distribution at smaller vertical angle and wind direction angle. The wind-induced response and its spectrums reveal that: when vertical angle is small, the background responsive values of reflector’s different parts are approximately similar; in addition, multi-phased resonant response occurring at the bottom. With the increase of , airflow separates at the near side and reunites at the other, as produces vortex which enhances dynamic response at the upper part.

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