A possible role for the exocrine pancreas in the pathogenesis of neonatal leucine-sensitive hypoglycemia

1970 ◽  
Vol 15 (1) ◽  
pp. 65-72 ◽  
Author(s):  
R. E. Brown ◽  
R. B. Young
Keyword(s):  
Exocrine Pancreas ◽  
Leucine Sensitive Hypoglycemia

MICROCHEMICAL ASSAYS OF GLUCOSE AND GLUCOSE-6-PHOSPHATE IN MAMMALIAN PANCREATIC β-CELLS

1968 ◽  
Vol 59 (3) ◽  
pp. 479-486 ◽  
Author(s):  
Lars-Ake Idahl ◽  
Bo Hellman
Keyword(s):  
Glucose Level ◽  
Exocrine Pancreas ◽  
The Other ◽  
Wide Concentration Range ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Enzymatic Cycling ◽  
Glucose Diffusion ◽  
Significant Barrier ◽  
The Brain

ABSTRACT The combination of enzymatic cycling and fluorometry was used for measuring glucose and glucose-6-phosphate in pancreatic β-cells from obese-hyperglycaemic mice. The glucose level of the β-cells corresponded to that of serum over a wide concentration range. In the exocrine pancreas, on the other hand, a significant barrier to glucose diffusion across the cell membranes was demonstrated. During 5 min of ischaemia, the glucose level remained practically unchanged in the β-cells while it increased in the liver and decreased in the brain. The observation that the pancreatic β-cells are characterized by a relatively low ratio of glucose-6-phosphate to glucose may be attributed to the presence of a specific glucose-6-phosphatase.

Response of Rat Exocrine Pancreas to High-Fat and High-Carbohydrate Diets

2000 ◽  
Vol 223 (3) ◽  
pp. 310-315 ◽  
Author(s):  
Parimal Chowdhury ◽  
Masahiro Nishikawa ◽  
George W. Blevins ◽  
Phillip L. Rayford
Keyword(s):  
Exocrine Pancreas ◽  
High Fat ◽  
High Carbohydrate ◽  
Rat Exocrine Pancreas

scholarly journals Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas

2021 ◽  
Author(s):  
Sophie C. Lodestijn ◽  
Tom van den Bosch ◽  
Lisanne E. Nijman ◽  
Leandro F. Moreno ◽  
Sophie Schlingemann ◽  
...  
Keyword(s):  
Exocrine Pancreas

scholarly journals Ca2+ Signaling and Its Potential Targeting in Pancreatic Ductal Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3085
Author(s):  
Louay Bettaieb ◽  
Maxime Brulé ◽  
Axel Chomy ◽  
Mel Diedro ◽  
Malory Fruit ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Exocrine Pancreas ◽  
Ductal Carcinoma ◽  
Ductal Adenocarcinoma ◽  
Molecular Devices ◽  
Pancreatic Ductal Carcinoma ◽  
Aberrant Expression ◽  
Common Cause ◽  
Cancer Hallmarks ◽  
Cancer Mutations

Pancreatic cancer (PC) is a major cause of cancer-associated mortality in Western countries (and estimated to be the second cause of cancer deaths by 2030). The main form of PC is pancreatic adenocarcinoma, which is the fourth most common cause of cancer-related death, and this situation has remained virtually unchanged for several decades. Pancreatic ductal adenocarcinoma (PDAC) is inherently linked to the unique physiology and microenvironment of the exocrine pancreas, such as pH, mechanical stress, and hypoxia. Of them, calcium (Ca2+) signals, being pivotal molecular devices in sensing and integrating signals from the microenvironment, are emerging to be particularly relevant in cancer. Mutations or aberrant expression of key proteins that control Ca2+ levels can cause deregulation of Ca2+-dependent effectors that control signaling pathways determining the cells’ behavior in a way that promotes pathophysiological cancer hallmarks, such as enhanced proliferation, survival and invasion. So far, it is essentially unknown how the cancer-associated Ca2+ signaling is regulated within the characteristic landscape of PDAC. This work provides a complete overview of the Ca2+ signaling and its main players in PDAC. Special consideration is given to the Ca2+ signaling as a potential target in PDAC treatment and its role in drug resistance.

scholarly journals Obesity causes PGC-1α deficiency in exocrine pancreas leading to IL-6 upregulation via NF-κB in acute pancreatitis

2021 ◽  
Vol 165 ◽  
pp. 36
Author(s):  
Sergio Rius-Pérez ◽  
Salvador Pérez ◽  
Pablo Martí-Andrés ◽  
Isabela Finamor ◽  
Ignacio Prieto ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Exocrine Pancreas
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