scholarly journals Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

2018 ◽  
Vol 9 ◽  
Author(s):  
Tamara Madácsy ◽  
Petra Pallagi ◽  
Jozsef Maleth
Keyword(s):  
Cystic Fibrosis ◽  
Mitochondrial Function ◽  
Exocrine Pancreas

scholarly journals Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 766
Author(s):  
David F. Woods ◽  
Stephanie Flynn ◽  
Jose A. Caparrós-Martín ◽  
Stephen M. Stick ◽  
F. Jerry Reen ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Bile Acids ◽  
Host Response ◽  
Signal Molecules ◽  
Therapeutic Approaches ◽  
Related Factors ◽  
Host Interactions ◽  
Important Host ◽  
Respiratory Microbiota

The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur and establish is largely unknown. This review is focused on the genetically inherited condition of Cystic Fibrosis (CF). Understanding the microbial and host-related factors that govern the establishment of chronic CF lung inflammation and pathogen colonisation is essential. Specifically, dissecting the interplay in the inflammation–pathogen–host axis. Bile acids are important host derived and microbially modified signal molecules that have been detected in CF lungs. These bile acids are associated with inflammation and restructuring of the lung microbiota linked to chronicity. This community remodelling involves a switch in the lung microbiota from a high biodiversity/low pathogen state to a low biodiversity/pathogen-dominated state. Bile acids are particularly associated with the dominance of Proteobacterial pathogens. The ability of bile acids to impact directly on both the lung microbiota and the host response offers a unifying principle underpinning the pathogenesis of CF. The modulating role of bile acids in lung microbiota dysbiosis and inflammation could offer new potential targets for designing innovative therapeutic approaches for respiratory disease.

Understanding the expanding role of pharmacy services in outpatient cystic fibrosis care

2021 ◽  
Author(s):  
Jeffery T. Zobell ◽  
Justin Moss ◽  
Stephanie Heuser ◽  
Lynda Roe ◽  
David C. Young
Keyword(s):  
Cystic Fibrosis ◽  
Pharmacy Services

scholarly journals WS02.2 Role of soluble and membrane-associated neutrophil elastase activity in cystic fibrosis sputum

2017 ◽  
Vol 16 ◽  
pp. S3
Author(s):  
A.S. Dittrich ◽  
I. Kühbandner ◽  
S. Gehrig ◽  
V. Rickert-Zacharias ◽  
C.C. Taggart ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Neutrophil Elastase ◽  
Elastase Activity ◽  
Cystic Fibrosis Sputum

Screening Policy for Cystic Fibrosis The Role of Evidence

1995 ◽  
Vol 25 (3) ◽  
pp. S21 ◽  
Author(s):  
Benjamin S. Wilfond
Keyword(s):  
Cystic Fibrosis ◽  
Screening Policy

scholarly journals Novel Role of miR-33 in Regulating of Mitochondrial Function

2015 ◽  
Vol 117 (3) ◽  
pp. 225-228 ◽  
Author(s):  
Nathan L. Price ◽  
Carlos Fernández-Hernando
Keyword(s):  
Mitochondrial Function
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