Hypertrophy of the small intestine after its partial resection in the rat

1969 ◽  
Vol 14 (3) ◽  
pp. 182-188 ◽  
Author(s):  
I. Skála ◽  
V. Konrádová
Keyword(s):  
Small Intestine ◽  
Partial Resection

Analysis of cloned cDNAs differentially expressed in adapting remnant small intestine after partial resection

1996 ◽  
Vol 271 (2) ◽  
pp. G347-G356 ◽  
Author(s):  
B. D. Dodson ◽  
J. L. Wang ◽  
E. A. Swietlicki ◽  
D. C. Rubin ◽  
M. S. Levin
Keyword(s):  
Small Intestine ◽  
Adaptive Response ◽  
Binding Protein ◽  
Intestinal Adaptation ◽  
Intestinal Resection ◽  
Partial Resection ◽  
Differentially Expressed ◽  
Cdna Clones ◽  
Regional Patterns ◽  
Fatty Acid Binding

After partial resection, the remnant small intestine undergoes an adaptive response. Little is known about the molecular and cellular basis of intestinal adaptation. To identify genes transcriptionally regulated in response to loss of functional bowel surface area, we have isolated cDNAs differentially expressed in the adaptive ileum 48 h after 70% proximal small intestinal resection. A cDNA library constructed from the remnant ileum of rats subjected to resection was screened using subtractive hybridization techniques. Several groups of cDNA clones that were induced during intestinal adaptation were isolated. The first included liver fatty acid binding protein, apolipoprotein A-IV, cellular retinol binding protein II, and ileal lipid binding protein. These all encode proteins involved in the absorption, metabolism, and trafficking of nutrients. A second group included the catalytic subunit of protein phosphatase 1 delta, a 78-kDa glucose-regulated protein (grp 78; a glucose-regulated member of the 70-kDa heat-shock protein family), and several pancreatitis-associated proteins. A third group of induced genes contained novel cDNAs. To better characterize the adaptive response, the temporal, spatial, and cellular patterns of expression of several of these genes were analyzed with the use of immunohistochemical and in situ hybridization techniques. These studies indicate that during early adaptation, genes involved in nutrient trafficking, protein processing, and cell cycle regulation are transcriptionally regulated in the residual small intestine in distinct temporal and regional patterns consistent with a complex multifaceted response to intestinal resection.

Hypertrophy of the Small Intestine after its Partial Resection in the Rat – Size of the Mucosal Surface

Digestion ◽  
1969 ◽  
Vol 2 (1) ◽  
pp. 23-34 ◽  
Author(s):  
I. Skála ◽  
V. Hromádková ◽  
J. Skála
Keyword(s):  
Small Intestine ◽  
Partial Resection ◽  
Mucosal Surface

Hypertrophy and Changes in Cholinesterase Activities of the Intestine, Erythrocytes and Plasma After ‘Partial’ Resection of the Small Intestine of the Rat

1958 ◽  
Vol 193 (3) ◽  
pp. 516-520 ◽  
Author(s):  
M. R. Loran ◽  
T. L. Althausen
Keyword(s):  
Small Intestine ◽  
Vitamin A ◽  
Cholinesterase Activity ◽  
Dry Weight ◽  
Partial Resection ◽  
Sham Operation ◽  
Intestinal Tissue ◽  
Abdominal Operation ◽  
Enzymatic Changes ◽  
Operation Results

‘Partial’ resection of the small intestine in rats resulted in a disproportionately great impairment of absorption of vitamin A and several lasting anatomical and enzymatic changes. Anatomical changes consisted of a true hypertrophy of the remaining intestine, indicated by an increase in its wet and dry weight. Simple transection produced some increase in the weight of the intestine, and sham operation resulted in loss of intestinal tissue. Our interpretation of these data is that the stress of the abdominal operation results in loss of intestinal tissue, whereas actual removal of a section of the intestine releases a mechanism for restoration of lost tissue. Enzymatic changes after resection consisted of an increase in cholinesterase activity of the intestine and erythrocytes, which was not observed after simple transection or sham operation. All three groups of rats showed an increase in cholinesterase activity of the plasma. Our tentative conclusions from these data are: a) Regenerated intestinal tissue is capable of synthesizing cholinesterase. b) Disproportionately greater impairment of intestinal absorption of vitamin A after resection may be caused in part by a disequilibrium in the acetylcholine-cholinesterase system in favor of cholinesterase. c) Increase in the specific cholinesterase activity of the erythrocytes may be related to the mechanism responsible for the intestinal hypertrophy. d) Increase in the cholinesterase activity of the plasma is caused by the abdominal operation per se.

scholarly journals Retinoic Acid Stimulates Early Cellular Proliferation in the Adapting Remnant Rat Small Intestine after Partial Resection

1997 ◽  
Vol 127 (7) ◽  
pp. 1297-1303 ◽  
Author(s):  
Joseph L. Wang ◽  
Deborah A. Swartz-Basile ◽  
Deborah C. Rubin ◽  
Marc S. Levin
Keyword(s):  
Small Intestine ◽  
Retinoic Acid ◽  
Cellular Proliferation ◽  
Partial Resection ◽  
Rat Small Intestine
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