Significance of geometrical reference models of the left ventricle for a new concept of evaluation of cardiac pumping function

1991 ◽  
Vol 86 (2) ◽  
pp. 186-196 ◽  
Author(s):  
B. Dierberger ◽  
M. Brändle ◽  
R. W. Gülch ◽  
R. Jacob
Keyword(s):  
Left Ventricle ◽  
Reference Models ◽  
Cardiac Pumping ◽  
Pumping Function

Abstract 13732: Evaluation of the Mechanical Effect of Thickened IPS Derived Cardiomyocyte Patch on the Distressed Left Ventricle Using Cardiac Simulator “Ut-heart”

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Hirotada Masuda ◽  
Shigeru Miyagawa ◽  
Takumi Washio ◽  
Seiryo Sugiura ◽  
Jun-ichi Okada ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Fiber Orientation ◽  
In Silico ◽  
Cell Sheet ◽  
Sheet Thickness ◽  
Mechanical Effect ◽  
Heart Model ◽  
Ips Cell ◽  
Lv Remodeling ◽  
Pumping Function

Introduction: iPS cell-derived cardiac cell sheet (iPS sheet) transplantation is expected to have both cytokine paracrine effect and mechanical effect on the failed heart. In order to clarify the latter effect, we utilized the cardiac simulator “UT-Heart” to quantitatively evaluate the improvement of pumping function of the left ventricle with myocardial infarction covered by the thickened iPS sheet in silico. The direct mechanical impact of iPS sheet with various thicknesses was calculated first, and then the remodeling effect of fiber orientation was investigated. Patient and Method: An infarcted heart model based on the actual patient’s data was created on the computer and an iPS sheet was virtually implanted under the following assumptions: (1) electrophysiologically synchronized with the underlying cardiac muscle, (2) covered the infarct area entirely, (3) the fiber orientation of sheet was parallel to that of the epicardial tissue when attached, (4) if remodeling occurs, the fiber orientations of myocardial tissue and the attached sheet change such that the contraction force and the fiber strains are homogenized in the heart. The UT-Heart simulation was performed while changing iPS sheet thickness from 1mm to 5mm. Results: The LVEF of 18.0 % at pre-implantation was improved to 18.5 % with 1 mm thickness, and 19.6 % with 5 mm thickness without remodeling assumption as shown in the left of the figure. If LV remodeling occurs, the LVEF was improved to 20.9 % with 1mm thickness and 22.8 % with 5mm thickness. The LVESP was 10 mmHg higher than that of pre-implantation even when 1mm thickness was implanted. Conclusion: The direct mechanical effect of the thickened iPS sheet on the distressed LV was quantitatively evaluated in silico. Because changes in fiber orientation have a significant impact on pumping function, the remodeling assumption used herein should be experimentally verified in the future.

Influence of 5-HT2 Receptor Agonist on Cardiac Pumping Function of Trained Offspring of Trained Rats

2012 ◽  
Vol 153 (3) ◽  
pp. 315-318 ◽  
Author(s):  
A. M. Valeev ◽  
N. I. Abzalov ◽  
R. A. Abzalov ◽  
R. R. Nigmatullina ◽  
R. R. Abzalov ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Cardiac Pumping ◽  
Pumping Function

scholarly journals Relation between mixed venous blood oxygen saturation and cardiac pumping function at the acute phase of myocardial infarction.

1989 ◽  
Vol 53 (12) ◽  
pp. 1481-1490 ◽  
Author(s):  
KEIKI KAN ◽  
TOSHIHIKO KOEDA ◽  
TAKASHI ICHIKAWA ◽  
TOMOYUKI SUZUKI ◽  
MIKIO KAWAKAMI ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Oxygen Saturation ◽  
Acute Phase ◽  
Venous Blood ◽  
Mixed Venous Blood ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Cardiac Pumping ◽  
Pumping Function ◽  
Mixed Venous

HEMODYNAMIC INFORMATION AND ANALYSIS OF CARDIAC PUMPING

2008 ◽  
Vol 08 (01) ◽  
pp. 87-95 ◽  
Author(s):  
T. K. HUNG ◽  
S. R. BALASUBRAMANIAN ◽  
M. A. SIMON ◽  
M. S. SUFFOLETTO ◽  
H. S. BOROVETZ ◽  
...  
Keyword(s):  
Blood Flow ◽  
Left Ventricle ◽  
Left Ventricle Ejection Fraction ◽  
Cardiac Pumping ◽  
Cardiac Evaluation ◽  
Hemodynamic Information ◽  
Work Done ◽  
Cardiac Indices ◽  
Viscous Stresses

This study extracted hemodynamic information from echocardiogram to complement the left ventricle ejection fraction and the stroke volume for cardiac evaluation and diagnosis. The dynamic characteristics of irregular wall motions can be analyzed by kinetic energy fluxes transferred from the left ventricle to the blood flow. A set of cardiac indices is developed for quantification and classification of echocardiogram for clinical application. The pumping characteristics can be further quantified through the work done by pressure and viscous stresses of the ventricle.

The characteristics of magnesium homeostasis and remodeling of heart in patients with ischemia of myocardium against the background of non-differentiated dysplasia of connective tissue

2016 ◽  
Vol 22 (5) ◽  
pp. 238-242
Author(s):  
Elizaveta P. Miroshnichenko ◽  
A. V Ushakov
Keyword(s):  
Connective Tissue ◽  
Left Ventricle ◽  
Blood Serum ◽  
Comparison Group ◽  
Control Group ◽  
Cardiovascular Pathology ◽  
Magnesium Homeostasis ◽  
Myocardium Infarction ◽  
Pumping Function ◽  
Healthy Persons

The study was carried out to evaluate dynamics of level of magnesium of blood serum and structural functional parameters of heart in patients with acute myocardium infarction developed against the background of non-differentiated dysplasia of connective tissue. The study included 90 patients with myocardium infarction with Q wave and with and without nondifferentiated dysplasia of connective tissue. The control group consisted of healthy persons and comparison group included patients with non-differentiated dysplasia of connective tissue without cardiovascular pathology. The clinical and phenotype examination including echocardiography testing of heart, detection of level of magnesium in blood serum in dynamics of myocardium infarction course were implemented. In patients with myocardium infarction, independently of occurrence of non-differentiated dysplasia of connective tissue during the first day of study decreasing of level of magnesium in blood serum was observed. In the group of patients with myocardium infarction, and non-differentiated dysplasia of connective tissue, up to twenty-eighth day, reliable decreasing of magnesium occurred as compared with control group and comparison group. In group of patients with myocardium infarction and non-differentiated dysplasia of connective tissue expressed increase of size of cavity of left ventricle was established including decreasing of its pumping function in combination with tendency to less expressed increasing of index of myocardium mass of left ventricle as compared with patients with myocardium infarction and without non-differentiated dysplasia of connective tissue. In patients with myocardium infarction occurring against the background of non-differentiated dysplasia of connective tissue hypomagnesemia is associated with development of desadaptive alternative of post-infarction remodeling of heart characterized by prevalence of processes of dilatation of cavity of left ventricle with decreasing of contractive capacity over processes of hypertrophy of myocardium.

Sign in / Sign up

Export Citation Format

Share Document