Randomized evaluation of benzathine penicillin V twice daily versus potassium penicillin V three times daily in the treatment of group A streptococcal pharyngitis

1995 ◽  
Vol 14 (2) ◽  
pp. 92-98 ◽  
Author(s):  
A. Kaufhold ◽  
Keyword(s):  
Streptococcal Pharyngitis ◽  
Benzathine Penicillin ◽  
Penicillin V ◽  
Randomized Evaluation ◽  
Group A ◽  
Potassium Penicillin

ERYTHROMYCIN PROPIONATE AND POTASSIUM PENICILLIN V IN THE TREATMENT OF GROUP A STREPTOCOCCAL PHARYNGITIS

PEDIATRICS ◽  
1963 ◽  
Vol 31 (1) ◽  
pp. 22-28
Author(s):  
Maxwell Stillerman ◽  
Stanley H. Bernstein ◽  
Martha Smith ◽  
Jack D. Gorvoy
Keyword(s):  
Relative Effectiveness ◽  
Streptococcal Pharyngitis ◽  
Group A Streptococci ◽  
Cure Rate ◽  
Acute Pharyngitis ◽  
Penicillin V ◽  
Daily Dose ◽  
Group A ◽  
Potassium Penicillin

The relative effectiveness of erythromycin propionate and K penicillin V in two dosage schedules was evaluated in the treatment of 261 cases of acute pharyngitis from which Group A hemolytic streptococci were recovered from December, 1958, to June, 1959. Erythromycin propionate, in a daily dose of 30 mg/kg up to 1.0 gm, and K penicillin V, in daily doses of 375 mg and 750 mg, were administered orally for 10 days. The adjusted bacterial cure rate was 78% among 86 patients treated with erythromycin, 72% among 102 patients treated with K penicillin V, 375 mg, and 88% among 73 patients treated with K penicillin V, 750 mg. The data indicate that K penicillin V was more effective in eradicating Group A streptococci from the pharynx in a daily dose of 750 mg than 375 mg, and suggest that erythromycin propionate in the dosage used, was less effective than K penicillin V, 750 mg, but equally as effective as K penicillin V, 375 mg daily. The incidence, time of occurrence, and results of retreatments of bacterial relapses are presented, and two possible causes of relapses are considered.

scholarly journals Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children.

1996 ◽  
Vol 40 (4) ◽  
pp. 1005-1008 ◽  
Author(s):  
L Pacifico ◽  
F Scopetti ◽  
A Ranucci ◽  
M Pataracchia ◽  
F Savignoni ◽  
...  
Keyword(s):  
Clinical Success ◽  
Streptococcal Pharyngitis ◽  
Efficacy And Safety ◽  
Comparative Efficacy ◽  
Once Daily ◽  
Penicillin V ◽  
Oral Regimen ◽  
Beta Hemolytic Streptococcus ◽  
Group A

The efficacy and safety of a 3-day course of azithromycin oral suspension (10 mg/kg of body weight once daily) were compared with those of penicillin V (50,000 U/kg/day in two divided doses) in children aged 3 to 12 years for the treatment of symptomatic pharyngitis caused by the group A beta-hemolytic streptococcus (GABHS). For the 154 evaluable patients, the original infecting strain of GABHS was eliminated at the end of follow-up (34 to 36 days after treatment started) from 67 (85.8%) of 78 penicillin-treated patients and 41 (53.9%) of 76 azithromycin-treated patients (P < 0.0001). Overall clinical success was achieved in 71 (91.0%) of 78 penicillin V-treated patients and 57 (75.0%) of 76 azithromycin-treated patients (P < 0.05). Potential drug-related adverse events were reported for 5.5 and 8.6% of the penicillin V- and azithromycin-treated patients, respectively (P = 0.6). In the present study, a once-daily (10 mg/kg), 3-day oral regimen of azithromycin was as safe as a 10-day course of penicillin but did not represent an effective alternative to penicillin for the treatment of GABHS pharyngitis, even for those children with azithromycin-susceptible strains.

Once-daily amoxicillin versus twice-daily penicillin V in group A  -haemolytic streptococcal pharyngitis

2008 ◽  
Vol 93 (6) ◽  
pp. 474-478 ◽  
Author(s):  
D R Lennon ◽  
E Farrell ◽  
D R Martin ◽  
J M Stewart
Keyword(s):  
Streptococcal Pharyngitis ◽  
Once Daily ◽  
Penicillin V ◽  
Group A

A double-blinded comparative study of sultamicillin and potassium penicillin V in the treatment of childhood streptococcal pharyngitis*

1984 ◽  
Vol 14 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Stephen C. Aronoff ◽  
Jeffrey D. Klinger ◽  
Cheryl A. O'Brien ◽  
Arthur C. Jaffe ◽  
Jeffrey L. Blumer
Keyword(s):  
Comparative Study ◽  
Streptococcal Pharyngitis ◽  
Penicillin V ◽  
Potassium Penicillin ◽  
Double Blinded

Ceftibuten vs. penicillin V in group A beta-hemolytic streptococcal pharyngitis

1995 ◽  
Vol 14 (Supplement) ◽  
pp. S102-107 ◽  
Author(s):  
MICHAEL E. PICHICHERO ◽  
SAMUEL E. MCLINN ◽  
W. MANFORD GOOCH ◽  
WILLIAM RODRIGUEZ ◽  
JOHANNA GOLDFARB ◽  
...  
Keyword(s):  
Streptococcal Pharyngitis ◽  
Penicillin V ◽  
Group A

Immediate vs. delayed treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin V

1991 ◽  
Vol 10 (2) ◽  
pp. 126-129 ◽  
Author(s):  
NAYEF TORKI EL-DAHER ◽  
SAʼAD SULAIMAN HIJAZI ◽  
NAYEL MOHAMMED RAWASHDEH ◽  
IHSAN ABDIL-HAMID AL-KHALIL ◽  
FAISAL MOHAMMED ABU-EKTAISH ◽  
...  
Keyword(s):  
Streptococcal Pharyngitis ◽  
Delayed Treatment ◽  
Penicillin V ◽  
Group A

ANTIBIOTICS IN THE TREATMENT OF BETA-HEMOLYTIC STREPTOCOCCAL PHARYNGITIS: FACTORS INFLUENCING THE RESULTS

PEDIATRICS ◽  
1960 ◽  
Vol 25 (1) ◽  
pp. 27-34
Author(s):  
Maxwell Stillerman ◽  
S. H. Bernstein ◽  
Martha L. Smith ◽  
Stanley B. Gittelson ◽  
Samuel Karelitz
Keyword(s):  
Clinical Manifestations ◽  
Streptococcal Pharyngitis ◽  
Penicillin G ◽  
Benzathine Penicillin ◽  
Cure Rate ◽  
Penicillin V ◽  
Significant Difference ◽  
Penicillin Therapy ◽  
Benzathine Penicillin G ◽  
Oral Doses

The effectiveness of penicillin V, penicillin V potassium, benzathine penicillin G, erythromycin and tetracycline in eradicating beta-hemolytic streptococci from the pharynx of 410 infected patients or carriers was studied. Penicillin V and penicillin V potassium were administered in daily oral doses of 375 to 750 mg (600,000 and 1,200,000 units), respectively, for 10 days. The benzathine penicillin G was injected once intramuscularly in similar doses. The broad spectrum antibiotics were given in daily oral doses of 30 to 50 mg/kg, up to 1 gm, for 10 days. The bacterial cure rate was 84% for 224 patients treated with penicillin V and penicillin V potassium, and 86% for 129 patients treated with benzathine penicillin G in combined doses. Forty-eight percent of 23 patients treated with erythromycin and 38% of 34 patients treated with tetracycline were cured. The majority of the clinical bacterial relapses developed 14 to 28 days after the onset of treatment with penicillin V orally and 24 to 32 days after benzathine penicillin G, 375 mg intramuscularly. Approximately half of the patients with bacterial relapses had clinical manifestations of pharyngitis. Factors which might be responsible for the development of relapses and failures are discussed. Complications consisted of one case of otitis media and one case of glomerulonephritis, developing 12 and 22 days, respectively, after the onset of treatment. No case of rheumatic fever was observed. The data indicate that penicillin was definitely more effective than erythromycin and tetracycline in eradiating beta-hemolytic streptococci from the host, in the doses used. There was no significant difference in the effectiveness of penicillin V, penicillin V potassium and benzathine penicillin G. Attention is drawn to the relapse-and-failure rate of 15% in these patients despite penicillin therapy.

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