Brain ischemia and gastric mucosal damage in spontaneously hypertensive rats

1996 ◽  
Vol 41 (12) ◽  
pp. 2383-2391 ◽  
Author(s):  
Keishi Kawakubo ◽  
Setsuro Ibayashi ◽  
Tetsuhiko Nagao ◽  
Kosei Doi ◽  
Kunihiko Aoyagi ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Spontaneously Hypertensive Rats ◽  
Mucosal Damage ◽  
Gastric Mucosal Damage ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Effects of supratentorial brain ischemia on cerebral and cerebellar blood flow autoregulations in spontaneously hypertensive rats

Nosotchu ◽  
1987 ◽  
Vol 9 (5) ◽  
pp. 456-462
Author(s):  
Osamu Shiokawa ◽  
Seizo Sadoshima ◽  
Fujio Yoshida ◽  
Kenichiro Fujii ◽  
Masatoshi Fujishima
Keyword(s):  
Blood Flow ◽  
Brain Ischemia ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Effect of thromboxane synthetase inhibitor, OKY-046, on brain ischemia in spontaneously hypertensive rats.

Nosotchu ◽  
1989 ◽  
Vol 11 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Seizo Sadoshima ◽  
Takao Ishitsuka ◽  
Kenichiro Fujii ◽  
Yasushi Okada ◽  
Masatoshi Fujishima
Keyword(s):  
Brain Ischemia ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Synthetase Inhibitor ◽  
Thromboxane Synthetase Inhibitor ◽  
Thromboxane Synthetase

scholarly journals Cell Permeable Exogenous Ceramide Reduces Infarct Size in Spontaneously Hypertensive Rats Supporting In Vitro Studies That Have Implicated Ceramide in Induction of Tolerance to Ischemia

2001 ◽  
Vol 21 (3) ◽  
pp. 226-232 ◽  
Author(s):  
Kazuhide Furuya ◽  
Irene Ginis ◽  
Hidetaka Takeda ◽  
Yong Chen ◽  
John M. Hallenbeck
Keyword(s):  
Brain Ischemia ◽  
Spontaneously Hypertensive Rats ◽  
Focal Cerebral Ischemia ◽  
Artery Occlusion ◽  
Brain Cell ◽  
In Vitro Studies ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Degree Of Protection

Previous work in primary cell culture has shown that TNF-α and ceramide are involved in the signaling that induces tolerance to brain ischemia ( Ginis et al., 1999 ; Liu et al., 2000 ). To validate the in vitro studies, the authors administered cell permeable analogs of ceramides intracisternally or intravenously to examine their effect on neuroprotection after focal cerebral ischemia. Permanent middle cerebral artery occlusion (MCAO) was performed in spontaneously hypertensive rats. Infarct volumes were assessed at 24 hours after surgery. D- erythro-N-acetylsphingosine (C2-ceramide) or its vehicle was infused intracisternally for 1 hour before MCAO. In a second set of studies, D- erythro-N-octanoylsphingosine (C8-ceramide) or its vehicle was injected intravenously 48 or 24 hours before MCAO to mimic preconditioning (PC) and was also injected 5 minutes after MCAO. C2-ceramide infusion significantly reduced infarct volumes by approximately 14% ( P < 0.05). C8-ceramide injection reduced infarct volumes approximately 17% compared with controls. This effect was constant and significant compared with controls over the time periods examined ( P < 0.01). This work supports findings in primary brain cell cultures that implicate ceramide as a downstream signal that is proximate to development of tolerance to brain ischemia. Because the degree of protection represents approximately 50% of the maximal infarct reduction observed in this model, there are probably additional signaling pathways that subserve tolerance.

scholarly journals IMM-H004, a coumarin derivative, attenuated brain ischemia/reperfusion injuries and subsequent inflammation in spontaneously hypertensive rats through inhibition of VCAM-1

RSC Advances ◽  
2017 ◽  
Vol 7 (44) ◽  
pp. 27480-27495 ◽  
Author(s):  
Peng-Fei Yang ◽  
Xiu-Yun Song ◽  
Ting Zeng ◽  
Qi-Di Ai ◽  
Dan-Dan Liu ◽  
...  
Keyword(s):  
Brain Ischemia ◽  
Spontaneously Hypertensive Rats ◽  
Infarct Volume ◽  
Ischemia Reperfusion ◽  
Coumarin Derivative ◽  
Dependent Manner ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Dose Dependent

We studied the effect of IMM-H004 in treating brain I/R injury in spontaneously hypertensive rats and showed that IMM-H004 could efficiently ameliorate neurological defects and infarct volume in a time and dose dependent manner.

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