Relevance of platelet serotonin and plasma tryptophan concentration in normal pregnant women and newborns to early child psychiatry

1993 ◽  
Vol 2 (4) ◽  
pp. 205-210 ◽  
Author(s):  
Elisabeth Flachaire ◽  
Nathalie Eynard ◽  
Martine Broyer ◽  
Anne Berthier ◽  
Claude Quincy ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Child Psychiatry ◽  
Early Child ◽  
Plasma Tryptophan ◽  
Platelet Serotonin ◽  
Tryptophan Concentration

scholarly journals Early child psychiatry

2010 ◽  
Vol 197 (2) ◽  
pp. 105-105 ◽  
Author(s):  
George Stein
Keyword(s):  
Personality Disorder ◽  
Maternal Depression ◽  
Child Psychiatry ◽  
Modern Concept ◽  
Parental Grief ◽  
Early Child

Disturbed and disobedient children can cause much distress to their parents, sometimes precipitating maternal depression. In the Book of Proverbs the word ‘fool’ denotes a character corresponding to the modern concept of personality disorder (mainly antisocial). Parental grief or depression associated with having a fool as a child is described in three separate entries:

Platelet serotonin content and free and total plasma tryptophan in healthy volunteers during 24 hours

1993 ◽  
Vol 39 (11) ◽  
pp. 2337-2340 ◽  
Author(s):  
N Eynard ◽  
E Flachaire ◽  
C Lestra ◽  
M Broyer ◽  
R Zaidan ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Healthy Volunteers ◽  
Psychiatric Disorders ◽  
Hplc Method ◽  
Total Plasma ◽  
Circadian Variations ◽  
Serotonin Content ◽  
Plasma Tryptophan ◽  
Platelet Serotonin

Abstract The determination of platelet serotonin (5-HT) and plasma tryptophan concentrations is useful in the diagnosis, investigation of etiologies, and treatment of psychiatric disorders. To determine the usual circadian variations in platelet 5-HT and free and total tryptophan concentrations, we measured these variables during 24 h at 1-h intervals and every 30 min from 2000 to 0800 in seven clinically healthy young men with an HPLC method. No common circadian rhythm for platelet serotonin concentrations was observed in our subjects; however, there was a distinct rhythm for both free and total plasma tryptophan: Concentrations were maximal in the afternoon and minimal during the night.

scholarly journals Platelet Serotonin and Plasma Tryptophan in Depressed Patients: Effect of Drug Treatment and Clinical Outcome

1994 ◽  
Vol 10 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Félicien Karege ◽  
Jean Widmer ◽  
Philippe Bovier ◽  
Jean-Michel Gaillard
Keyword(s):  
Clinical Outcome ◽  
Drug Treatment ◽  
Plasma Tryptophan ◽  
Depressed Patients ◽  
Platelet Serotonin

scholarly journals 2.L. Workshop: Poor parental mental health and impacts on early child health in the context of Danish welfare state

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
◽  
Keyword(s):  
Mental Health ◽  
Child Health ◽  
Pregnant Women ◽  
Socioeconomic Position ◽  
Mental Health Problems ◽  
Health Problems ◽  
Poor Mental Health ◽  
Parental Mental Health ◽  
Early Child ◽  
The Impact

Abstract Globally, the prevalence of mental health problems is high and seems to be increasing and it estimated that 10-20% of pregnant women experience poor perinatal mental health. In the future, more children may grow up in families where one or both parents are struggling with mental health problems. Poor mental health is linked to wider determinants of health as low social position increase the risk of poor mental health and may limit access to care. Moreover, poor mental health can negatively impact the social position and resources of individuals and families as well as child health, thus representing an important public health challenge. The foundation of life-long health is laid before birth and in early childhood, and a better understanding of the impact of poor parental health and other determinants of early child health is crucial. This workshop aims to A) offer new insights on the impact of early child health of poor parental health in the context of Denmark, a Nordic welfare state with strong principles of free and equal access to health care services. Also, B) it encourages a discussion about the main challenges and new ways to support families and through this improve short- and long-term child health and potentially also parental health. The knowledge presented as point of departure for discussions, derives from two new Danish studies. One is a qualitative study of the experiences of pregnant women/new parents receiving targeted, community-based perinatal services due to mental health problems. This gives voice to parents' own perspectives of the services they have offered and their lived experiences with poor mental health and parenthood. The other study is the epidemiological CoVer-P project (Children of Vulnerable Parents) based on a cohort of all live-born children born in Denmark 2000-2016 and their parents and a large range of data from Danish nationwide registers. This large cohort have allowed studies that address existing knowledge gabs by examining different severity levels of parental mental health problems, the impact of also the father's mental health and the interaction between mental health and socioeconomic position. The workshop will start with a short introduction and invitation to share thoughts it's topic from the chair (5 min) followed by four 10-minut presentations. First, Frederiksen shares her insights on pregnant women/new parents with mental health problems and their lived experiences. Secondly, Knudsen & Christesen analyse the effect of maternal mental health and socioeconomic position on the risk of preterm birth. Thirdly, Christensen reports new knowledge about perinatal outcomes of infants born to mothers with poor mental health. Fourth, Heuckendorff describes the impact of the mental health as well as socioeconomic position of both mother and father on child morbidity, age 1-6. In the final part of the workshop (15 min), the chair will introduce and moderate a general discussion of aim B with the audience Key messages Share knowledge on how poor parental mental health may affect perinatal and child negatively, presenting an important public health challenge. Raise awareness about the needs and perspective of parents with poor mental health and raise discussion about how to improve services and support.

scholarly journals The tryptophan requirement of the kitten

1983 ◽  
Vol 50 (2) ◽  
pp. 487-493 ◽  
Author(s):  
Diane M. Hargrove ◽  
Quinton R. Rogers ◽  
James G. Morris
Keyword(s):  
Weight Gain ◽  
Latin Square ◽  
Nitrogen Retention ◽  
Daily Weight Gain ◽  
Plasma Tryptophan ◽  
Tryptophan Concentration

1. To estimate the tryptophan requirement of the kitten, six male and six female kittens were presented diets containing 0·7, 0·9, 1·1, 1·3, 1·5 and 3·0 g tryptophan/kg diet for six experimental periods lasting 10 d in accordance with a 6 × 6 balanced Latin-square design.2. Mean daily weight gain and nitrogen retention (N intake minus urinary and faecal N) plateaued at 1·1 g tryptophan/kg diet indicating that the minimal tryptophan requirement of the kitten was 1·1 g/kg diet.3. Plasma tryptophan concentration exhibited a marked increase at dietary tryptophan concentrations above 1·3 g/kg diet.

scholarly journals Use of selective serotonin reuptake inhibitors is associated with very low plasma-free serotonin concentrations in humans

2019 ◽  
Vol 57 (1) ◽  
pp. 59-63
Author(s):  
Marloes AM Peters ◽  
Martijn van Faassen ◽  
Wilhelmina HA de Jong ◽  
Grietje Bouma ◽  
Coby Meijer ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Reuptake ◽  
High Speed ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Plasma Concentrations ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Blood Collection ◽  
Plasma Tryptophan ◽  
Platelet Serotonin

Background Selective serotonin reuptake inhibitors (SSRIs) block the serotonin transporter on neurons, but also on platelets, thus decreasing platelet serotonin concentrations in users of SSRIs. Data on plasma-free serotonin concentrations in SSRI users are lacking, while plasma-free serotonin is available for receptor binding and plays a role in several pathophysiological processes. We therefore measured the plasma-free and platelet serotonin concentrations in users of SSRIs and age-matched healthy controls, and we analysed plasma concentrations of the serotonin precursor tryptophan and serotonin metabolite 5-hydroxyindoleamineacetic acid (5-HIAA). Methods For this cross-sectional single-centre case control study, participants were recruited at the departments of Psychiatry and General Medicine. High-performance liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) was used to measure plasma-free and platelet serotonin, plasma tryptophan and 5-HIAA concentrations. Preanalytical conditions were optimized by careful blood collection, rapid sample handling, high-speed centrifugation, drug and diet restrictions and age-matched controls. Results In 64 SSRI users, median concentrations of plasma-free and platelet serotonin were 10-fold and 14-fold lower, respectively, than in 64 matched controls. Patients using higher dose SSRIs or those with higher affinity for the serotonin transporter had lower plasma-free and platelet serotonin concentrations. Compared with controls, SSRI users had similar median plasma tryptophan concentrations but slightly higher plasma 5-HIAA concentrations. Conclusion SSRI users have low platelet serotonin and low plasma-free serotonin. This could not be explained by lower concentrations of its precursor tryptophan, and only partially by increased breakdown to 5-HIAA.

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