scholarly journals Platelet Serotonin and Plasma Tryptophan in Depressed Patients: Effect of Drug Treatment and Clinical Outcome

1994 ◽  
Vol 10 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Félicien Karege ◽  
Jean Widmer ◽  
Philippe Bovier ◽  
Jean-Michel Gaillard
Keyword(s):  
Clinical Outcome ◽  
Drug Treatment ◽  
Plasma Tryptophan ◽  
Depressed Patients ◽  
Platelet Serotonin

Comparative trial of L-tryptophan and amitriptyline in depressive illness

1977 ◽  
Vol 6 (4) ◽  
pp. 673-678 ◽  
Author(s):  
R. N. Herrington ◽  
A. Bruce ◽  
E. C. Johnstone ◽  
M. H. Lader
Keyword(s):  
Drug Treatment ◽  
Comparative Trial ◽  
Depressive Illness ◽  
Maximal Dose ◽  
Double Blind ◽  
Moderate Severity ◽  
Treatment Groups ◽  
The Third ◽  
Depressed Patients

SynopsisDepressed patients who were suitable for drug treatment were allocated randomly to treatment for four weeks with either amitriptyline in doses reaching 150 mg daily or with l-tryptophan in a maximal dose of 8 G daily. Both in-patients and out-patients were included. The trial was double-blind and ratings were made at the start of treatment and weekly for the subsequent four weeks: the patients were then followed for a further six months. Both groups of patients improved steadily over the course of four weeks and there were no marked differences between the treatment groups though there was some tendency for the improvement of the tryptophan-treated patients to fade between the third and fourth weeks. Within the tryptophan group anxious patients improved least. It is concluded that L-tryptophan probably has some antidepressive action in patients with depressive illness of moderate severity.

Platelet serotonin content and free and total plasma tryptophan in healthy volunteers during 24 hours

1993 ◽  
Vol 39 (11) ◽  
pp. 2337-2340 ◽  
Author(s):  
N Eynard ◽  
E Flachaire ◽  
C Lestra ◽  
M Broyer ◽  
R Zaidan ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Healthy Volunteers ◽  
Psychiatric Disorders ◽  
Hplc Method ◽  
Total Plasma ◽  
Circadian Variations ◽  
Serotonin Content ◽  
Plasma Tryptophan ◽  
Platelet Serotonin

Abstract The determination of platelet serotonin (5-HT) and plasma tryptophan concentrations is useful in the diagnosis, investigation of etiologies, and treatment of psychiatric disorders. To determine the usual circadian variations in platelet 5-HT and free and total tryptophan concentrations, we measured these variables during 24 h at 1-h intervals and every 30 min from 2000 to 0800 in seven clinically healthy young men with an HPLC method. No common circadian rhythm for platelet serotonin concentrations was observed in our subjects; however, there was a distinct rhythm for both free and total plasma tryptophan: Concentrations were maximal in the afternoon and minimal during the night.

Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients

2021 ◽  
Vol 105 ◽  
pp. 110016 ◽  
Author(s):  
Anja Dvojkovic ◽  
Matea Nikolac Perkovic ◽  
Marina Sagud ◽  
Gordana Nedic Erjavec ◽  
Alma Mihaljevic Peles ◽  
...  
Keyword(s):  
Depressed Patients ◽  
Platelet Serotonin

Personality Traits Influence Clinical Outcome in Day Hospital-Treated Elderly Depressed Patients

2009 ◽  
Vol 17 (4) ◽  
pp. 335-343 ◽  
Author(s):  
Alessandra Canuto ◽  
Panteleimon Giannakopoulos ◽  
Corina Meiler-Mititelu ◽  
Christophe Delaloye ◽  
François R. Herrmann ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Personality Traits ◽  
Day Hospital ◽  
Depressed Patients

A kinetic analysis and replication of decreased platelet serotonin uptake in depressed patients

1986 ◽  
Vol 19 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Jeffrey L. Rausch ◽  
David S. Janowsky ◽  
S.Craig Risch ◽  
Leighton Y. Huey
Keyword(s):  
Kinetic Analysis ◽  
Serotonin Uptake ◽  
Depressed Patients ◽  
Platelet Serotonin

Serotonergic Dysfunction in Depression

1989 ◽  
Vol 155 (S8) ◽  
pp. 25-31 ◽  
Author(s):  
Herbert Meltzer
Keyword(s):  
Tryptophan Hydroxylase ◽  
Rating Scale ◽  
Blood Platelets ◽  
Antidepressant Drugs ◽  
Depression Score ◽  
Plasma Tryptophan ◽  
Depressed Patients ◽  
Hydroxyindoleacetic Acid ◽  
Serotonergic Function ◽  
Neuroendocrine Challenge

Various irregularities in serotonin (5-HT) function have been postulated as causes of affective disorders. Serotonin has been related to many of the major symptoms of depression, e.g. mood, appetite, sleep, activity, and cognitive dysfunction. Interference with 5-HT synthesis or storage has been shown to induce depression in vulnerable individuals. Decreased levels of 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid, decreased plasma tryptophan, low tryptophan neutral amino acid ratio, abnormalities in serotonergic function indicated by neuroendocrine challenge tests and various platelet measures, have been reported in depressed patients. Concentrations of 5-HIAA, the major metabolite of 5-HT in plasma, were found to be significantly negatively correlated with severity of depression as measured by the Hamilton Rating Scale for Depression score and specific depressive symptoms, despite the fact that plasma 5-HIAA is largely peripheral in origin. Blood platelets, which have been suggested as models for serotonergic nerve terminals, have a significantly decreased number of 5-HT uptake sites and 3H-imipramine binding sites in depressed patients. Antidepressant drugs may act, in part, by enhancing serotonergic activity. The serotonergic deficit may occur at any of several levels: diminished availability of precursor, impaired activity of tryptophan hydroxylase, abnormalities in 5-HT release or uptake, 5-HT receptor abnormalities or interactions with other neurotransmitters.

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