Apoptosis occurs in lymphoma cells but not in hepatoma cells following ionizing radiation and photodynamic therapy

1994 ◽  
Vol 39 (11) ◽  
pp. 2467-2475 ◽  
Author(s):  
Mark A. Laukka ◽  
Kenneth K. Wang ◽  
James A. Bonner
Keyword(s):  
Photodynamic Therapy ◽  
Ionizing Radiation ◽  
Hepatoma Cells ◽  
Lymphoma Cells

Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells

APOPTOSIS ◽  
2006 ◽  
Vol 11 (11) ◽  
pp. 2031-2042 ◽  
Author(s):  
Ingegerd Eggen Furre ◽  
Michael T. N. Møller ◽  
Susan Shahzidi ◽  
Jahn M. Nesland ◽  
Qian Peng
Keyword(s):  
Photodynamic Therapy ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Apoptotic Induction

scholarly journals Effects of HPV Status on Responsiveness to Ionizing Radiation vs Photodynamic Therapy in Head and Neck Cancer Cell lines

2019 ◽  
Vol 96 (3) ◽  
pp. 652-657 ◽  
Author(s):  
David Kessel ◽  
Won Jin Cho ◽  
Joseph Rakowski ◽  
Harold E. Kim ◽  
Hyeong‐Reh C. Kim
Keyword(s):  
Head And Neck Cancer ◽  
Photodynamic Therapy ◽  
Ionizing Radiation ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Cancer Cell Lines ◽  
Hpv Status

scholarly journals APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair

Blood ◽  
2012 ◽  
Vol 120 (2) ◽  
pp. 366-375 ◽  
Author(s):  
Roni Nowarski ◽  
Ofer I. Wilner ◽  
Ori Cheshin ◽  
Or D. Shahar ◽  
Edan Kenig ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Genomic Dna ◽  
Cytidine Deaminase ◽  
Dna Double Strand Breaks ◽  
Dsb Repair ◽  
Lymphoma Cells ◽  
Direct Role ◽  
Cytidine Deaminase Activity ◽  
Retroviral Replication ◽  
Apobec3g Expression

Abstract APOBEC3 proteins catalyze deamination of cytidines in single-stranded DNA (ssDNA), providing innate protection against retroviral replication by inducing deleterious dC > dU hypermutation of replication intermediates. APOBEC3G expression is induced in mitogen-activated lymphocytes; however, no physiologic role related to lymphoid cell proliferation has yet to be determined. Moreover, whether APOBEC3G cytidine deaminase activity transcends to processing cellular genomic DNA is unknown. Here we show that lymphoma cells expressing high APOBEC3G levels display efficient repair of genomic DNA double-strand breaks (DSBs) induced by ionizing radiation and enhanced survival of irradiated cells. APOBEC3G transiently accumulated in the nucleus in response to ionizing radiation and was recruited to DSB repair foci. Consistent with a direct role in DSB repair, inhibition of APOBEC3G expression or deaminase activity resulted in deficient DSB repair, whereas reconstitution of APOBEC3G expression in leukemia cells enhanced DSB repair. APOBEC3G activity involved processing of DNA flanking a DSB in an integrated reporter cassette. Atomic force microscopy indicated that APOBEC3G multimers associate with ssDNA termini, triggering multimer disassembly to multiple catalytic units. These results identify APOBEC3G as a prosurvival factor in lymphoma cells, marking APOBEC3G as a potential target for sensitizing lymphoma to radiation therapy.

scholarly journals Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

RSC Advances ◽  
2019 ◽  
Vol 9 (51) ◽  
pp. 29936-29941 ◽  
Author(s):  
Ge Wang ◽  
Jing Liu ◽  
Lin Zhu ◽  
Yuming Guo ◽  
Lin Yang
Keyword(s):  
Photodynamic Therapy ◽  
Energy Metabolism ◽  
Silver Sulfide ◽  
Light Irradiation ◽  
Hybrid Nanoparticles ◽  
Reactive Oxidative Species ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Silver Sulfide Nanoparticles ◽  
Oxidative Species

Ag2S/BSA hybrid nanoparticles were prepared and studied for their ability to inhibit the growth of human lymphoma cells under light irradiation, via inducing the accumulation of intracellular reactive oxidative species to disrupt energy metabolism.

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