Carcinomas of the colon with multidirectional differentiation

1995 ◽  
Vol 40 (1) ◽  
pp. 100-106 ◽  
Author(s):  
Pierre Novello ◽  
Pierre Duvillard ◽  
Sophie Grandjouan ◽  
Dominique Elias ◽  
Philippe Rougier ◽  
...  
Keyword(s):  
Multidirectional Differentiation

scholarly journals Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Geru Zhang ◽  
Qiwen Li ◽  
Quan Yuan ◽  
Shiwen Zhang
Keyword(s):  
Stem Cells ◽  
Spatial Distribution ◽  
Stem Cell ◽  
Cranial Sutures ◽  
Stem Cell Markers ◽  
Spatial Distributions ◽  
Self Renewal ◽  
Stem Cell Niches ◽  
Multidirectional Differentiation

Stem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomandibular joint, cranial sutures, and periodontium. These cells exhibit self-renewal and multidirectional differentiation abilities. Here, we summarized the properties of craniofacial skeletal stem cells, based on their spatial distribution. Specifically, we focused on the in vivo genetic fate mapping of stem cells, by exploring specific stem cell markers and observing their lineage commitment in both the homeostatic and regenerative states. Finally, we discussed their application in regenerative medicine.

scholarly journals Primary epithelioid sarcoma of scalp

2017 ◽  
Vol 03 (01) ◽  
pp. 071-073 ◽  
Author(s):  
Sushma Gurwale ◽  
Charusheela Gore ◽  
Supreet Kaur ◽  
Anjali Deshpande
Keyword(s):  
Genital Tract ◽  
Older Patients ◽  
Cervical Lymph Node ◽  
Histopathological Examination ◽  
Epithelioid Sarcoma ◽  
Cervical Lymph Node Metastasis ◽  
Older Individuals ◽  
Male Predominance ◽  
Node Metastasis ◽  
Multidirectional Differentiation

AbstractEpithelioid sarcoma (ES) is a rare mesenchymal tumor of unknown histogenesis which displays multidirectional differentiation, predominantly epithelial. They have no normal cellular counterpart and differ from both synovial sarcoma and other carcinomas. It mainly affects young adults. It has two variants, classic type and proximal type. The more common classic type presents as a slowly growing painless nodule or plaque on the distal extremities. It is rare in children and older individuals. There is male predominance. The size varies from few millimeters to several centimeters. Central deeply seated lesions in pelvis and genital tract are termed as proximal ES. It has a multinodular growth pattern and usually occurs in older patients. These are comparatively more aggressive and metastasize early. On histopathological examination, these lesions need to be distinguished from other tumors showing epithelioid morphology. Primary ES of scalp is an exceedingly rare tumor. We present a case of nodular tumor on the scalp with cervical lymph node metastasis.

Photocontrolled Multidirectional Differentiation of Mesenchymal Stem Cells on an Upconversion Substrate

2018 ◽  
Vol 57 (35) ◽  
pp. 11182-11187 ◽  
Author(s):  
Zhengqing Yan ◽  
Hongshuang Qin ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Multidirectional Differentiation

scholarly journals Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Hong Yang ◽  
Yuexia Liu ◽  
Xuanchen Liu ◽  
Huihui Gu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Mesenchymal Stem Cell ◽  
Bone Repair ◽  
Stem Cell Differentiation ◽  
Lysine Acetylation ◽  
Myocardial Repair ◽  
Differentiation Potential ◽  
Mesenchymal Stem Cell Differentiation ◽  
Multidirectional Differentiation

Nowadays, the use of MSCs has attracted considerable attention in the global science and technology field, with the self-renewal and multidirectional differentiation potential for diabetes, obesity treatment, bone repair, nerve repair, myocardial repair, and so on. Epigenetics plays an important role in the regulation of mesenchymal stem cell differentiation, which has become a research hotspot in the medical field. This review focuses on the role of lysine acetylation modification on the determination of MSC differentiation direction. During this progress, the recruitment of lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) is the crux of transcriptional mechanisms in the dynamic regulation of key genes controlling MSC multidirectional differentiation.

scholarly journals Antioxidants inhibit cell senescence and preserve stemness of adipose tissue-derived stem cells by reducing ROS generation during long-term in vitro expansion

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Naishun Liao ◽  
Yingjun Shi ◽  
Cuilin Zhang ◽  
Youshi Zheng ◽  
Yingchao Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Cell Senescence ◽  
Ros Generation ◽  
Differentiation Potential ◽  
Cell Functions ◽  
Multidirectional Differentiation

Abstract Background Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting in failure of ADSC-based therapy. Methods In this study, ADSCs were treated with low dose of antioxidants (reduced glutathione and melatonin) with anti-aging and stem cell protection properties in the in vitro passaging, and the cell functions including stem cell senescence, cell migration, cell multidirectional differentiation potential, and ROS content were carefully analyzed. Results We found that GSH and melatonin could maintain ADSC cell functions through reducing cell senescence and promoting cell migration, as well as by preserving stemness and multidirectional differentiation potential, through inhibiting ROS generation during long-term expansion of ADSCs. Conclusions Our results suggested that antioxidant treatment could efficiently prevent the dysfunction and preserve cell functions of ADSCs after long-term passaging, providing a practical strategy to facilitate ADSC-based therapy.

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