Erythropoietic stimulation enhances, and erythropoietic inhibition suppresses, multidirectional differentiation in 5-day transient endogenous spleen colonies

1981 ◽  
Vol 37 (9) ◽  
pp. 1024-1026 ◽  
Author(s):  
W. Wiktor-Jedrzejczak
Keyword(s):  
Endogenous Spleen Colonies ◽  
Multidirectional Differentiation

Survival and endogenous spleen colonies of irradiated mice after skin wounding and hydroxyurea treatment

1982 ◽  
Vol 38 (10) ◽  
pp. 1228-1230 ◽  
Author(s):  
G. D. Ledney ◽  
H. M. Gelston ◽  
S. R. Weinberg ◽  
E. D. Exum
Keyword(s):  
Hydroxyurea Treatment ◽  
Endogenous Spleen Colonies ◽  
Skin Wounding

scholarly journals Spatial Distributions, Characteristics, and Applications of Craniofacial Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Geru Zhang ◽  
Qiwen Li ◽  
Quan Yuan ◽  
Shiwen Zhang
Keyword(s):  
Stem Cells ◽  
Spatial Distribution ◽  
Stem Cell ◽  
Cranial Sutures ◽  
Stem Cell Markers ◽  
Spatial Distributions ◽  
Self Renewal ◽  
Stem Cell Niches ◽  
Multidirectional Differentiation

Stem cells play an irreplaceable role in the development, homeostasis, and regeneration of the craniofacial bone. Multiple populations of tissue-resident craniofacial skeletal stem cells have been identified in different stem cell niches, including the cranial periosteum, jawbone marrow, temporomandibular joint, cranial sutures, and periodontium. These cells exhibit self-renewal and multidirectional differentiation abilities. Here, we summarized the properties of craniofacial skeletal stem cells, based on their spatial distribution. Specifically, we focused on the in vivo genetic fate mapping of stem cells, by exploring specific stem cell markers and observing their lineage commitment in both the homeostatic and regenerative states. Finally, we discussed their application in regenerative medicine.

Carcinomas of the colon with multidirectional differentiation

1995 ◽  
Vol 40 (1) ◽  
pp. 100-106 ◽  
Author(s):  
Pierre Novello ◽  
Pierre Duvillard ◽  
Sophie Grandjouan ◽  
Dominique Elias ◽  
Philippe Rougier ◽  
...  
Keyword(s):  
Multidirectional Differentiation

scholarly journals Primary epithelioid sarcoma of scalp

2017 ◽  
Vol 03 (01) ◽  
pp. 071-073 ◽  
Author(s):  
Sushma Gurwale ◽  
Charusheela Gore ◽  
Supreet Kaur ◽  
Anjali Deshpande
Keyword(s):  
Genital Tract ◽  
Older Patients ◽  
Cervical Lymph Node ◽  
Histopathological Examination ◽  
Epithelioid Sarcoma ◽  
Cervical Lymph Node Metastasis ◽  
Older Individuals ◽  
Male Predominance ◽  
Node Metastasis ◽  
Multidirectional Differentiation

AbstractEpithelioid sarcoma (ES) is a rare mesenchymal tumor of unknown histogenesis which displays multidirectional differentiation, predominantly epithelial. They have no normal cellular counterpart and differ from both synovial sarcoma and other carcinomas. It mainly affects young adults. It has two variants, classic type and proximal type. The more common classic type presents as a slowly growing painless nodule or plaque on the distal extremities. It is rare in children and older individuals. There is male predominance. The size varies from few millimeters to several centimeters. Central deeply seated lesions in pelvis and genital tract are termed as proximal ES. It has a multinodular growth pattern and usually occurs in older patients. These are comparatively more aggressive and metastasize early. On histopathological examination, these lesions need to be distinguished from other tumors showing epithelioid morphology. Primary ES of scalp is an exceedingly rare tumor. We present a case of nodular tumor on the scalp with cervical lymph node metastasis.

Photocontrolled Multidirectional Differentiation of Mesenchymal Stem Cells on an Upconversion Substrate

2018 ◽  
Vol 57 (35) ◽  
pp. 11182-11187 ◽  
Author(s):  
Zhengqing Yan ◽  
Hongshuang Qin ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Multidirectional Differentiation

scholarly journals Patterns of Proliferation and Differentiation of Hematopoietic Stem Cells After Compartment Depletion

Blood ◽  
1971 ◽  
Vol 37 (5) ◽  
pp. 568-580 ◽  
Author(s):  
PAUL A. CHERVENICK ◽  
DANE R. BOGGS
Keyword(s):  
Stem Cell ◽  
Cell Compartment ◽  
Hematopoietic Stem ◽  
Split Dose ◽  
Stem Cell Compartment ◽  
Dose Irradiation ◽  
Proliferation And Differentiation ◽  
Self Replication ◽  
Higher Doses ◽  
Endogenous Spleen Colonies

Abstract The time of onset and rate of self-replication in the irradiation depleted pluripotential hematopoietic stem cell compartment of mice was measured by a split-dose irradiation method. Mice were irradiated to reduce the compartment size and at daily intervals thereafter were again irradiated; 10 days after the second irradiation the number of endogenous spleen colonies was determined. As irradiation interval was lengthened, colonies increased in an exponential fashion with no apparent lag interval after the first irradiation. The doubling time of the colony-forming cell compartment was calculated as 16 hr if severely reduced in size by 300 R or more but was slower if less irradiation was given. The time of resumption of erythropoiesis following irradiation was measured after 100-900 R by determining uptake of radioactive iron into marrow, spleen, and circulating red cells each day after irradiation. With 200 R or less, erythropoiesis was not abolished. With higher doses there was an interval of no apparent erythropoiesis which increased by 1.6 days for each increment of 100 R. These results are compatible with a pluripotential stem cell compartment, which (1) begins self replication almost immediately following compartment size reduction, and (2) will not differentiate if reduced in size below approximately 10% of normal.

scholarly journals HEMOPOIETIC SPLEEN COLONY STUDIES

1967 ◽  
Vol 126 (5) ◽  
pp. 819-832 ◽  
Author(s):  
J. L. Curry ◽  
J. J. Trentin
Keyword(s):  
Bone Marrow ◽  
Cell Types ◽  
Slight Reduction ◽  
Normal Bone Marrow ◽  
Mixed Cell ◽  
Colony Forming Unit ◽  
Normal Bone ◽  
Endogenous Spleen Colonies

The effects of phytohemagglutinin (PHA) were studied in irradiated mice to see if a definite myeloproliferative effect could be demonstrated in vivo. The data obtained suggested the following conclusions. PHA treatment of the bone marrow donor only, causes a consistent but slight reduction in transplantable spleen colony-forming unit (CFU) content of the bone marrow 24 hr after the last PHA injection, but no change was found in the proportion of the various colony types. PHA treatment of the irradiated recipient of normal bone marrow causes no change in the number of spleen colonies. However, 8-day colonies are only about half normal size, are much more likely to be of mixed cell types, contain many large undifferentiated blastoid cells, but fewer transplantable CFU. The spleen sinusoids are packed with hemopoietic cells. Spleen colonies developing in hosts receiving daily injections of PHA show, in addition to the usual spectrum of cell types, a high proportion of unusual blastoid cells resembling the PHA transformed peripheral lymphocytes seen in vitro. The function of these cells is not known, but they may represent augmented proliferation and/or transformation of stem cells. PHA administered after irradiation significantly increased the number of endogenous spleen colonies, and, at certain doses of irradiation, improved postirradiation survival. PHA administered before irradiation had no effect on the number of endogenous spleen colonies formed, or on postirradiation survival. On the basis of these and other data, possible modes of action of PHA are discussed.

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