Long term observations on the articular cartilage and autologous costal cartilage transplanted to osteochondral defects on the femoral head

1972 ◽  
Vol 9 (1) ◽  
pp. 226-237 ◽  
Author(s):  
Sven-Olof Hjertquist ◽  
Rudolf Lemperg
Keyword(s):  
Articular Cartilage ◽  
Femoral Head ◽  
Costal Cartilage ◽  
Osteochondral Defects

Experimental Studies on Repair of Large Osteochondral Defects at a High Weight Bearing Area of the Knee Joint: A Tissue Engineering Study

1991 ◽  
Vol 113 (2) ◽  
pp. 198-207 ◽  
Author(s):  
V. C. Mow ◽  
A. Ratcliffe ◽  
M. P. Rosenwasser ◽  
J. A. Buckwalter
Keyword(s):  
Animal Model ◽  
Growth Factors ◽  
Articular Cartilage ◽  
High Weight ◽  
Weight Bearing ◽  
Osteochondral Defects ◽  
Repair Tissue ◽  
Weight Bearing Area ◽  
Grafting Procedure

There is a vast clinical need for the development of an animal model to study the fundamentals of healing of injured or diseased diarthrodial joints (knee, hip, shoulder, wrist, etc). Current prosthetic replacements do not offer acceptable treatment for injuries and diseases of these joints in young active individuals. New clinical treatment modalities, based on sound biologic principles, are sought for the development of repair or healing tissues engineered to have similar biomechanical properties as normal articular cartilage. In this paper we present a brief review of this need, and propose a grafting procedure which may lead to a successful animal model for studies of long term repair of major osteochondral defects. This grafting procedure uses an autologous periosteum-bone graft or an autologous-synthetic bone replacement graft. We have applied these grafts for in vivo repair of large surgically created defects in the high weight bearing area of the distal femoral condyle of mature New Zealand white rabbits. Further, an interdisciplinary study, including histochemistry, biochemistry (composition and metabolic activities), and biomechanics (biphasic properties), was performed to assess the feasibility of our animal model to generate viable repair tissues. We found our grafting procedure produced, 8 weeks postoperatively, tissues which were very similar to those found in normal articular cartilage. However, our histological studies indicate incomplete bonding between the repair tissue and the adjacent cartilage, and lack of an appropriate superficial zone at the articular surface. These deficiencies may cause long term failure of the repair tissue. Further studies must be undertaken to enhance development of a strong bond and a collagen-rich surface zone. This may require the use of growth factors (e.g., transforming growth factors β) capable of simulating extra collagen production, or the use of serum derived tissue glue for bonding. At present, we are pursuing these studies.

scholarly journals Use of the HemiCAP partial hip resurfacing technique for traumatic femoral head osteochondral defects following obturator hip dislocations

SICOT-J ◽  
2018 ◽  
Vol 4 ◽  
pp. 3 ◽  
Author(s):  
Varun Arora ◽  
Pierre Navarre ◽  
Mathias Russ ◽  
Max Esser
Keyword(s):  
Femoral Head ◽  
Treatment Options ◽  
Hip Resurfacing ◽  
Osteochondral Defects ◽  
Challenging Problem ◽  
Long Term Outcomes ◽  
Secondary Osteoarthritis ◽  
Osteoarthritis Treatment ◽  
Surgical Fixation

Fracture of the femoral head (OTA 31-C1.3) following anterior obturator dislocations are a challenging problem as the fractures are often communited, impacted and with loose osteochondral fragments, making surgical fixation difficult. This can result in residual articular defects if the fragments cannot be internally fixed and need be excised, predisposing to secondary osteoarthritis. Treatment options for these defects are limited, have variable results and with limited literature to guide us on outcomes due to the rarity of these injuries. Here, we describe the first use of the technique of partial femoral head resurfacing in two patients with such fractures and report on their long term outcomes.

Effects of Long-Term Running Exercise on Canine Femoral Head Articular Cartilage

1993 ◽  
pp. 95-99
Author(s):  
M. J. Lammi ◽  
T. P. Häkkinen ◽  
J. J. Parkkinen ◽  
M. Hyttinen ◽  
M. Jortikka ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Femoral Head ◽  
Running Exercise

Large fresh osteochondral allografts for the hip: growing the evidence

2017 ◽  
Vol 28 (3) ◽  
pp. 284-290 ◽  
Author(s):  
Lasun O Oladeji ◽  
James L Cook ◽  
James P Stannard ◽  
Brett D Crist
Keyword(s):  
Articular Cartilage ◽  
Femoral Head ◽  
Functional Outcomes ◽  
Survival Rates ◽  
Osteochondral Allograft ◽  
Cartilage Lesions ◽  
Concomitant Procedure ◽  
Institutional Review ◽  
Articular Cartilage Lesions

Introduction: Articular cartilage lesions of the hip are difficult to effectively treat. Osteochondral allograft (OCA) transplantation in the knee has been associated with long-term success, but OCA for the hip has not been extensively studied. Here, we present the clinical and radiological outcomes from a cohort of 10 patients treated with fresh OCA transplants for large osteochondral defects of the femoral head and/or acetabulum. Methods: 10 patients who had undergone osteochondral allograft transplantation of the femoral head and/or acetabulum at our institution between 2013 and 2016 were identified from our Institutional Review Board-approved registry. Hip disability and Osteoarthritis Outcome Score (HOOS) was used to track patient progress. Results: 10 patients with an average clinical follow-up of 1.4 years were included in this study. 4 patients were treated solely with OCA plugs for femoral head defects, while the remaining 6 received femoral OCA plugs and at least 1 concomitant procedure for additional intraarticular pathology. 7 patients (70%) had successful functional outcomes, while 3 (30%) had unsuccessful outcomes and were subsequently converted to total hip arthroplasty (THA) 5 to 29 months after OCA. Conclusions: OCA transplantation can be an effective treatment strategy for young, healthy individuals with articular cartilage lesions of the hip. Smoking, avascular necrosis aetiology, acetabular involvement and concomitant procedures may be risk factors for unsuccessful outcomes necessitating salvage with THA. Long-term clinical studies to refine indications and determine functional outcomes and survival rates are warranted.

Influence of Permeability on the Compressive Property of Articular Cartilage: A Scaffold-Free, Stem Cell-Based Therapy for Cartilage Repair

2011 ◽  
Author(s):  
Tomoya Susa ◽  
Ryosuke Nansai ◽  
Norimasa Nakamura ◽  
Hiromichi Fujie
Keyword(s):  
Articular Cartilage ◽  
Superficial Layer ◽  
Cell Delivery ◽  
Compressive Property ◽  
Chondral Defect ◽  
Element Analysis ◽  
Normal Cartilage ◽  
Cell Based Therapy ◽  
Immunological Effects

Since the healing capacity of articular cartilage is limited, it is important to develop cell-based therapies for the repair of cartilage. Although synthetic or animal-derived scaffolds are frequently used for effective cell delivery long-term safety and efficiency of such scaffolds still remain unclear. We have been studying on a scaffold-free tissue engineered construct (TEC) bio-synthesized from synovium-derived mesenchymal stem cells (MSCs) [1]. As the TEC specimen is composed of cells with their native extracellular matrix, we believe that it is free from concern regarding long term immunological effects. our previous studies indicated that a porcine partial thickness chondral defect was successfully repaired with TEC but that the compressive property of the TEC-treated cartilage-like repaired tissue was different from normal cartilage in both immature and mature animals. Imura et al. found that the permeability of the immature porcine cartilage-like tissues repaired with TEC recovered to normal level for 6 months except the superficial layer [2]. Therefore, the present study was performed to determine the depth-dependent permeability of mature porcine cartilage-like tissue repaired with TEC. Moreover, we investigated the effect of difference of permeability on the compressive property of articular cartilage using a finite element analysis (FEM).

Embryonic Stem Cells Form Articular Cartilage, not Teratomas, in Osteochondral Defects of Rat Joints

2004 ◽  
Vol 13 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Shigeyuki Wakitani ◽  
Hideyuki Aoki ◽  
Yasuji Harada ◽  
Masato Sonobe ◽  
Yusuke Morita ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Osteochondral Defects
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