Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis

1991 ◽  
Vol 34 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Francesco Tonelli ◽  
Franca Bianchini ◽  
Maura Lodovici ◽  
Rosa Valanzano ◽  
Giovanna Caderni ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cell Proliferation ◽  
Ileorectal Anastomosis ◽  
Rectal Stump ◽  
Mucosal Cell ◽  
Mucosal Cell Proliferation

scholarly journals Localization and significance of pp55, a gastric mucosal membrane protein with tyrosine kinase activity

1998 ◽  
Vol 274 (5) ◽  
pp. G863-G870 ◽  
Author(s):  
Adhip P. N. Majumdar ◽  
James R. Goldenring
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Mucosal Cell ◽  
Mucous Cells ◽  
Tyrosine Kinase Activity ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Mucosal Cell Proliferation

In Fischer 344 rats, induction of gastric mucosal proliferative activity, whether the result of aging or injury or occurring after administration of epidermal growth factor, gastrin, or bombesin, is associated with a rise in tyrosine kinase activity and tyrosine phosphorylation of several mucosal proteins, including a protein with a molecular mass of 53–55 kDa. We hypothesized that this phosphotyrosine membrane protein (referred to as pp55) may play a role in regulating gastric mucosal cell proliferation and differentiation. Purification and subsequent immunoprecipitation studies now show that pp55 is a tyrosine kinase. In addition, the enzyme activity in the gastric mucosa is found to be fourfold higher in aged rats than in young rats. Incubation of gastric mucosal membranes with transforming growth factor-α (2 × 10−8 M) stimulates tyrosine kinase activity of pp55. Immuolocalization studies reveal that pp55 immunoreactivity is predominantly present in mucous cells that are located just above the proliferative zone and spasmolytic peptide-immunoreactive mucous neck cells. Tyrosine kinase activity as well as expression of pp55 are also greatly increased in the gastric mucosa after hypertonic saline-induced injury, a condition that results in stimulation of surface mucosal cell proliferation and differentiation. Our current data suggest that pp55 is a tyrosine kinase, likely localized to pre-surface cells. The presence of pp55 in pre-surface mucous cells and the expression and tyrosine kinase activity of this protein, which can be stimulated during mucosal cell proliferation and differentiation, strongly suggest a role for pp55 in differentiation of gastric surface mucous cells.

Polyamines and intestinal growth--increased polyamine biosynthesis after jejunectomy

1983 ◽  
Vol 245 (5) ◽  
pp. G656-G660 ◽  
Author(s):  
G. D. Luk ◽  
S. B. Baylin
Keyword(s):  
Cell Proliferation ◽  
Intestinal Adaptation ◽  
Intestinal Resection ◽  
Crypt Cell ◽  
Mucosal Cell ◽  
Ileal Mucosa ◽  
Cell Hyperplasia ◽  
Polyamine Biosynthesis ◽  
Crypt Cell Proliferation ◽  
Mucosal Cell Proliferation

Transient increases in the activities of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAM-DC), key enzymes in polyamine biosynthesis, may be critical to initiation of cell growth. We now report that such increases in ODC (X170) and SAM-DC (X83) activities, and their synthetic products putrescine (X4) and spermidine (X2), occur in rat ileal mucosa between days 1 and 4 after 50% intestinal resection. This is the time period of initiation of mucosal cell hyperplasia in intestinal adaptation after resection and is characterized by increased mucosal cell proliferation, as measured morphologically and biochemically. Intestinal weight increased by 76% and mucosal thickness by 48%. Mucosal DNA content increased by 67% and mucosal DNA synthesis by 104%. Increased intestinal crypt cell proliferation was manifested by a 120% increase in labeling per crypt and a 152% increase in crypt cell production rate (CCPR). The increase in ODC activity was closely associated with the increases in CCPR and rate of villus lengthening. Rates of mucosal cell proliferation, as measured by CCPR, and villus and crypt lengthening were significantly correlated with ODC activity (r = 0.97, 0.98, and 0.94, respectively; P less than 0.01 for all). Our results indicate that the increase in ODC activity, SAM-DC activity, and polyamine biosynthesis is closely associated with the process of adaptive postresectional crypt cell proliferation.

scholarly journals Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer.

Gut ◽  
1989 ◽  
Vol 30 (3) ◽  
pp. 376-382 ◽  
Author(s):  
R C Gregoire ◽  
H S Stern ◽  
K S Yeung ◽  
J Stadler ◽  
S Langley ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
High Risk ◽  
Calcium Supplementation ◽  
Mucosal Cell ◽  
High Risk Patients ◽  
Risk Patients ◽  
Mucosal Cell Proliferation

scholarly journals Effects of different phytosterol analogs on colonic mucosal cell proliferation in hamsters

2006 ◽  
Vol 17 (6) ◽  
pp. 396-401 ◽  
Author(s):  
Xiaoming Jia ◽  
Naoyuki Ebine ◽  
Yanwen Wang ◽  
Atif B. Awad ◽  
Peter J.H. Jones
Keyword(s):  
Cell Proliferation ◽  
Mucosal Cell ◽  
Mucosal Cell Proliferation
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