Colectomy with ileorectal anastomosis lowers rectal mucosal cell proliferation in familial adenomatous polyposis

1993 ◽  
Vol 36 (2) ◽  
pp. 167-171 ◽  
Author(s):  
K. C. R. Farmer ◽  
R. K. S. Phillips
Keyword(s):  
Cell Proliferation ◽  
Familial Adenomatous Polyposis ◽  
Ileorectal Anastomosis ◽  
Mucosal Cell ◽  
Adenomatous Polyposis ◽  
Mucosal Cell Proliferation

Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis

1991 ◽  
Vol 34 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Francesco Tonelli ◽  
Franca Bianchini ◽  
Maura Lodovici ◽  
Rosa Valanzano ◽  
Giovanna Caderni ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Cell Proliferation ◽  
Ileorectal Anastomosis ◽  
Rectal Stump ◽  
Mucosal Cell ◽  
Mucosal Cell Proliferation

scholarly journals DNA aneuploidy and cell proliferation in familial adenomatous polyposis.

Gut ◽  
1988 ◽  
Vol 29 (5) ◽  
pp. 603-607 ◽  
Author(s):  
P Quirke ◽  
M F Dixon ◽  
D W Day ◽  
J B Fozard ◽  
I C Talbot ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Familial Adenomatous Polyposis ◽  
Adenomatous Polyposis ◽  
Dna Aneuploidy

scholarly journals Localization and significance of pp55, a gastric mucosal membrane protein with tyrosine kinase activity

1998 ◽  
Vol 274 (5) ◽  
pp. G863-G870 ◽  
Author(s):  
Adhip P. N. Majumdar ◽  
James R. Goldenring
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Mucosal Cell ◽  
Mucous Cells ◽  
Tyrosine Kinase Activity ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Mucosal Cell Proliferation

In Fischer 344 rats, induction of gastric mucosal proliferative activity, whether the result of aging or injury or occurring after administration of epidermal growth factor, gastrin, or bombesin, is associated with a rise in tyrosine kinase activity and tyrosine phosphorylation of several mucosal proteins, including a protein with a molecular mass of 53–55 kDa. We hypothesized that this phosphotyrosine membrane protein (referred to as pp55) may play a role in regulating gastric mucosal cell proliferation and differentiation. Purification and subsequent immunoprecipitation studies now show that pp55 is a tyrosine kinase. In addition, the enzyme activity in the gastric mucosa is found to be fourfold higher in aged rats than in young rats. Incubation of gastric mucosal membranes with transforming growth factor-α (2 × 10−8 M) stimulates tyrosine kinase activity of pp55. Immuolocalization studies reveal that pp55 immunoreactivity is predominantly present in mucous cells that are located just above the proliferative zone and spasmolytic peptide-immunoreactive mucous neck cells. Tyrosine kinase activity as well as expression of pp55 are also greatly increased in the gastric mucosa after hypertonic saline-induced injury, a condition that results in stimulation of surface mucosal cell proliferation and differentiation. Our current data suggest that pp55 is a tyrosine kinase, likely localized to pre-surface cells. The presence of pp55 in pre-surface mucous cells and the expression and tyrosine kinase activity of this protein, which can be stimulated during mucosal cell proliferation and differentiation, strongly suggest a role for pp55 in differentiation of gastric surface mucous cells.

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