Pharmacological studies on thiamine deficiency IV. Blood catecholamine content and blood pressure of thiamine deficient rats

1969 ◽  
Vol 25 (3) ◽  
pp. 283-284 ◽  
Author(s):  
H. Iwata ◽  
T. Nishikawa ◽  
K. Watanabe
Keyword(s):  
Blood Pressure ◽  
Thiamine Deficiency ◽  
Catecholamine Content ◽  
Pharmacological Studies

scholarly journals Intratubular and intracellular renin–angiotensin system in the kidney: a unifying perspective in blood pressure control

2018 ◽  
Vol 132 (13) ◽  
pp. 1383-1401 ◽  
Author(s):  
Xiao C. Li ◽  
Dongmin Zhu ◽  
Xiaowen Zheng ◽  
Jiangfeng Zhang ◽  
Jia L. Zhuo
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin System ◽  
Pressure Control ◽  
Integrative Approach ◽  
Angiotensin System ◽  
Physiological Regulation ◽  
Renin Angiotensin ◽  
Vasoactive Peptides ◽  
Pharmacological Studies ◽  
Regulation Of Blood Pressure

The renin–angiotensin system (RAS) is widely recognized as one of the most important vasoactive hormonal systems in the physiological regulation of blood pressure and the development of hypertension. This recognition is derived from, and supported by, extensive molecular, cellular, genetic, and pharmacological studies on the circulating (tissue-to-tissue), paracrine (cell-to-cell), and intracrine (intracellular, mitochondrial, nuclear) RAS during last several decades. Now, it is widely accepted that circulating and local RAS may act independently or interactively, to regulate sympathetic activity, systemic and renal hemodynamics, body salt and fluid balance, and blood pressure homeostasis. However, there remains continuous debate with respect to the specific sources of intratubular and intracellular RAS in the kidney and other tissues, the relative contributions of the circulating RAS to intratubular and intracellular RAS, and the roles of intratubular compared with intracellular RAS to the normal control of blood pressure or the development of angiotensin II (ANG II)-dependent hypertension. Based on a lecture given at the recent XI International Symposium on Vasoactive Peptides held in Horizonte, Brazil, this article reviews recent studies using mouse models with global, kidney- or proximal tubule-specific overexpression (knockin) or deletion (knockout) of components of the RAS or its receptors. Although much knowledge has been gained from cell- and tissue-specific transgenic or knockout models, a unifying and integrative approach is now required to better understand how the circulating and local intratubular/intracellular RAS act independently, or with other vasoactive systems, to regulate blood pressure, cardiovascular and kidney function.

Pharmacokinetic and Pharmacological Studies with Clonidine in Normal Subjects

1976 ◽  
Vol 51 (s3) ◽  
pp. 639s-640s
Author(s):  
D. S. Davies ◽  
L. M. H. Wing ◽  
J. L. Reid ◽  
P. Tippett ◽  
C. T. Dollery
Keyword(s):  
Blood Pressure ◽  
Stable Isotope ◽  
Isotope Dilution ◽  
Normal Subjects ◽  
Salivary Flow ◽  
Mass Fragmentography ◽  
Sensitive Assay ◽  
Stable Isotope Dilution ◽  
Pharmacological Studies ◽  
Normotensive Subjects

1. A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. 2. Plasma half-lives of clonidine ranged from 6·9 to 9·4 h in five normotensive subjects. 3. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

Inhibitors of Phenylethanolamine-N-Methyltransferase: Effects on Brain Catecholamine Content and Blood Pressure in DOCA-Salt Hypertensive Rats

1985 ◽  
Vol 133 (6) ◽  
pp. 1130-1131
Author(s):  
N.Y. Liang ◽  
A. Chandra ◽  
R.E. Tessel ◽  
G.L. Grunewald ◽  
R.T. Borchardt
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Catecholamine Content
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