Pharmacokinetic and Pharmacological Studies with Clonidine in Normal Subjects

1976 ◽  
Vol 51 (s3) ◽  
pp. 639s-640s
Author(s):  
D. S. Davies ◽  
L. M. H. Wing ◽  
J. L. Reid ◽  
P. Tippett ◽  
C. T. Dollery
Keyword(s):  
Blood Pressure ◽  
Stable Isotope ◽  
Isotope Dilution ◽  
Normal Subjects ◽  
Salivary Flow ◽  
Mass Fragmentography ◽  
Sensitive Assay ◽  
Stable Isotope Dilution ◽  
Pharmacological Studies ◽  
Normotensive Subjects

1. A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. 2. Plasma half-lives of clonidine ranged from 6·9 to 9·4 h in five normotensive subjects. 3. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

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