Five-year results of a randomized clinical trial comparing modified radical mastectomy and extended radical mastectomy for stage II breast cancer

Surgery Today ◽  
1994 ◽  
Vol 24 (3) ◽  
pp. 210-214 ◽  
Author(s):  
Tadaoki Morimoto ◽  
Yasumasa Monden ◽  
Shigemitsu Takashima ◽  
Sueyoshi Itoh ◽  
Takashi Kimura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Radical Mastectomy ◽  
Stage Ii ◽  
Modified Radical Mastectomy ◽  
Extended Radical Mastectomy

scholarly journals Effectiveness of Cyanoacrylate in Reducing Seroma Formation in Breast Cancer Patients Post-Axillary Dissection: A Randomized Controlled Trial

2021 ◽  
Vol 10 ◽  
Author(s):  
Mahmoud Al-Masri ◽  
Fade Alawneh ◽  
Faiez Daoud ◽  
Ali Ebous ◽  
Basem Hamdan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Axillary Dissection ◽  
Radical Mastectomy ◽  
Cost Effective ◽  
Seroma Formation ◽  
Modified Radical Mastectomy ◽  
Node Positive ◽  
Drain Removal ◽  
Positive Breast Cancer

Background/PurposeSeroma is a common complication after axillary dissection in women with node-positive breast cancer. We aim to determine the effect of Cyanoacrylate on reducing seroma formation in patients undergoing axillary dissection. This a randomized clinical trial.MethodsThis is a single-center, randomized, single-blinded, and two-arm parallel study. Women with node-positive breast cancer eligible for axillary dissection were enrolled. Patients with a Body Mass Index (BMI) greater than 35 kg/m2, those who underwent immediate breast reconstruction, and/or received neoadjuvant chemotherapy were excluded. Patients were randomized in a 1:1 ratio, and were stratified according to their age, BMI, tumor size, and operation type. The primary endpoint was the total seroma volume (the total drained volume and the total aspirated volume after drain removal). Data presented as mean and range when applicable.Results111 patients were randomized (Cyanoacrylate 57; control 54). 105 patients were analyzed. Sixty-nine patients underwent breast conserving surgery, and 36 underwent modified radical mastectomy. There was no difference in the total seroma volume between the Cyanoacrylate vs. control arms (1,304 (60–4,950) vs. 1,446 (100–5,223) ml, p=0.458). Wound infection, flap necrosis, number of manual aspirates, and hematoma formation were not statistically different between the two groups. Time to drain removal was shorter in the Cyanoacrylate arm (11.04(3–23) vs. 13.84(3–37) days, p=0.015). The use of Cyanoacrylate was not cost effective ($586.93 (550–748) vs. $29.63 (0–198), p<0.001). Higher seroma volume was correlated with modified radical mastectomy, older age, and BMI more than 30 kg/m2.ConclusionCyanoacrylate did not reduce seroma formation and its use was not cost effective.Clinical Trial Registrationclinicaltrials.gov, identifier NCT02141373.

scholarly journals Effect of a preoperative single-dose steroid on pulmonary function and postoperative symptoms after modified radical mastectomy: results of a randomized clinical trial

Gland Surgery ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1313-1327
Author(s):  
Jorge Jiménez-Tornero ◽  
Ana Olivia Cortés-Flores ◽  
Mariana Chávez-Tostado ◽  
Gilberto Morgan-Villela ◽  
Carlos Zuloaga-Fernández del Valle ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Pulmonary Function ◽  
Randomized Clinical Trial ◽  
Radical Mastectomy ◽  
Modified Radical Mastectomy ◽  
Postoperative Symptoms
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