Dantrolene: evidence for effects on Na permeability properties of the nodal membrane

1983 ◽  
Vol 39 (7) ◽  
pp. 755-756 ◽  
Author(s):  
J. R. Schwarz ◽  
R. P. Spielmann
1989 ◽  
Vol 49 ◽  
pp. 169
Author(s):  
Hideto Awano ◽  
Tetsuya Hasegawa ◽  
Masakazu Nishimura ◽  
Osamu Yagasaki ◽  
Katsuaki Ito

1988 ◽  
Vol 405 (1) ◽  
pp. 77-103 ◽  
Author(s):  
R C Boucher ◽  
C U Cotton ◽  
J T Gatzy ◽  
M R Knowles ◽  
J R Yankaskas

2016 ◽  
Vol 469 (1) ◽  
pp. 149-158 ◽  
Author(s):  
Nina Himmerkus ◽  
Allein Plain ◽  
Rita D. Marques ◽  
Svenja R. Sonntag ◽  
Alexander Paliege ◽  
...  

1976 ◽  
Vol 39 (1) ◽  
pp. 153-161 ◽  
Author(s):  
S. H. Thompson ◽  
S. J. Smith

1. Spikes in molluscan bursting cells are followed by depolarizing afterpotentials (DAPs) which are not seen in nonbursting cells in the same ganglia. DAPs from successive spikes sum to provide a depolarizing drive capable of sustaining multiple discharge. 2. Subthreshold depolarization activates a DAP-like process in bursters. 3. DAP amplitude increases as the cell is hyperpolarized beyond the potassium equilibrium potential. The amplitude is not changed by intracellular iontophoresis of TEA-Cl. DAP amplitude is reduced by 39% after a 10-min exposure to CA++-free saline, and by 66% after 10 min in 4% Na+ (Tris substituted) saline. The amplitude is unchanged by exposure to K+-free saline. 4. During repetitive stimulation the amplitude of the summed DAP declines. 5. It is concluded that DAP results from a slowly decaying component of Ca++ and Na+ permeability.


1984 ◽  
Vol 246 (4) ◽  
pp. F517-F525 ◽  
Author(s):  
C. S. Park ◽  
I. S. Edelman

The effects of aldosterone on the functional characteristics of the Na+ entry step across the apical membrane and on the Na+ exit step across the basolateral membrane of the urinary bladder of toads were examined using amiloride and ouabain as probes of the respective surfaces of the cell. Aldosterone stimulated Na+ transport with a concurrent increase in the transepithelial electrical conductance as did two other agents, vasopressin (ADH) and p-chloromercuriphenylsulfonate (PCMPS), primarily active on the apical membrane. Unlike the effects of ADH and PCMPS, however, the effect of aldosterone on Na+ conductance was blocked by actinomycin D and was associated with a decreased sensitivity of the apical Na+ channel to amiloride. In addition, aldosterone increased the sensitivity of the Na+ pump on the basolateral side to ouabain, an effect that was dependent on the metabolic state of the urinary bladder. These results support the inference of coordinate effects on Na+ permeability of the apical membrane and the Na+ pump of the basolateral membrane. Both effects of aldosterone appear to be dependent on the metabolic state of the transporting epithelium.


1996 ◽  
Vol 152 (3) ◽  
pp. 207-215 ◽  
Author(s):  
M.L. Chalfant ◽  
J.M. Civan ◽  
K. Peterson-Yantorno ◽  
D.R. DiBona ◽  
T.G. O'Brien

Nature ◽  
1981 ◽  
Vol 290 (5807) ◽  
pp. 598-600 ◽  
Author(s):  
Ofer Binah ◽  
Yoram Palti

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