Potassium channels in the nodal membrane of rat myelinated fibres

Nature ◽  
1981 ◽  
Vol 290 (5807) ◽  
pp. 598-600 ◽  
Author(s):  
Ofer Binah ◽  
Yoram Palti
Keyword(s):  
Potassium Channels ◽  
Nodal Membrane ◽  
Myelinated Fibres

Development of the axon membrane during differentiation of myelinated fibres in spinal nerve roots

1980 ◽  
Vol 209 (1176) ◽  
pp. 441-446 ◽  
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Spinal Nerve ◽  
Spinal Nerve Roots ◽  
Nerve Roots ◽  
Axon Membrane ◽  
Nodal Membrane ◽  
Spinal Roots ◽  
Myelinated Fibres

Previous studies by a number of workers have shown that the axon membrane in normal mature myelinated fibres is highly differentiated, with the nodal axolemma exhibiting characteristics different to those of the internodal axolemma. However, the development of this axolemmal heterogeneity has not been previously explored. In the present study we used cytochemical methods to examine the development of nodal axolemma during the differentiation of myelinated fibres in rat spinal roots. The staining properties characteristic of normal nodal membrane appear in the axon, at gaps between Schwann cells, before the develop­ment of mature compact myelin or well defined paranodal axon-Schwann cell specializations close to the region of nodal axolemmal differentiation. These results are consistent with the hypothesis that the axon membrane differentiates into nodal and internodal regions before, or early in the process of, myelination, and suggest that the differentiation of the axon membrane may provide a signal demarcating the region to be covered by the myelin-forming cell.

The cole-moore effect in nodal membrane of the frogRana ridibunda: Evidence for fast and slow potassium channels

1980 ◽  
Vol 57 (3) ◽  
pp. 179-193 ◽  
Author(s):  
V. I. Ilyin ◽  
Irene E. Katina ◽  
A. V. Lonskii ◽  
V. S. Makovsky ◽  
E. V. Polishchuk
Keyword(s):  
Potassium Channels ◽  
Nodal Membrane ◽  
Slow Potassium

Organization of the axolemma in amyelinated axons: a cytochemical study in dy/dy dystrophic mice

1978 ◽  
Vol 201 (1144) ◽  
pp. 301-308 ◽  
Keyword(s):  
Genetic Defect ◽  
Cytochemical Study ◽  
Axon Membrane ◽  
Channel Density ◽  
Nodal Membrane ◽  
Pharmacological Data ◽  
Structural Differences ◽  
Myelinated Fibres ◽  
Dystrophic Mice ◽  
Dystrophic Axon

Previous studies using a variety of techniques have shown that in normal myelinated fibres there are structural differences between the axon membrane at nodes of Ranvier and in the internodes beneath the myelin sheath. The present paper reports the results of a cytochemical study on the axon membrane in amyelinated axons in dy/dy dystrophic mice, in which myelination is focally absent owing to a genetic defect. The results indicate that the amyelinated axon membrane, which is known to be capable of sustaining continuous impulse conduction, is structurally different from normal nodal membrane. Comparison of the cytochemical results with physiological and pharmacological data suggests that the amyelinated dystrophic axon membrane may exhibit a lower sodium channel density than normal nodal membrane.

Potassium channels in nodal and internodal axonal membrane of mammalian myelinated fibres

Nature ◽  
1980 ◽  
Vol 284 (5752) ◽  
pp. 170-171 ◽  
Author(s):  
S. Y. Chiu ◽  
J. M. Ritchie
Keyword(s):  
Potassium Channels ◽  
Axonal Membrane ◽  
Myelinated Fibres
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