5-Methyl-2-phenyl-isoxazolidine-3-one and the erythropoietic system

1969 ◽  
Vol 1 (1) ◽  
pp. 39-41
Author(s):  
K. Bucher
Keyword(s):  
Erythropoietic System

Comparison of tin and lead toxic action on erythropoietic system in blood and bone marrow of rabbits

1993 ◽  
Vol 36 (1) ◽  
pp. 73-87 ◽  
Author(s):  
Jadwiga Chmielnicka ◽  
Grażyna Zareba ◽  
Eugenia Polkowska-Kulesza ◽  
Maria Najder ◽  
Anna Korycka
Keyword(s):  
Bone Marrow ◽  
Toxic Action ◽  
Erythropoietic System

scholarly journals Erythroblastopenia (Pure Red Cell Aplasia) in Childhood in Djakarta

Blood ◽  
1962 ◽  
Vol 19 (2) ◽  
pp. 168-180 ◽  
Author(s):  
L. K. KHO ◽  
O. ODANG ◽  
S. THAJEB ◽  
A. H. MARKUM
Keyword(s):  
Bone Marrow ◽  
Pure Red Cell Aplasia ◽  
Clinical Findings ◽  
Acute Type ◽  
Red Cell ◽  
Vitamin Deficiencies ◽  
Red Cell Aplasia ◽  
Reticular Cells ◽  
Erythropoietic System ◽  
Observation Period

Abstract Erythroblastopenia or pure red cell aplasia was encountered in 186 children during an observation period of five years in the Pediatric Department in Djakarta, Indonesia. Twenty cases were of the acute type of erythroblastopenia, distinguished by a sudden drop of the hemoglobin content of the blood, reticulocytopenia, and disappearance of the erythroblasts in the bone marrow. Giant red cell precursors (giant reticular cells and proerythroblasts) appeared in the bone marrow. This condition lasted two days to two weeks. A subacute type of erythroblastopenia with a duration of two weeks to two months was found in 25 cases. The last group consisted of 141 cases of subchronic or chronic erythroblastopenia with a duration of more than two months. Malnutrition, infections and vitamin deficiencies were the main clinical findings in these children. The authors are of the opinion that erythroblastopenia is a maturation arrest of the erythropoietic system caused by protein deficiency and/or temporary deficiencies of one or more erythrocyte maturation or stimulating factors.

Cell death and the efficiency of the erythropoietic system

1996 ◽  
Vol 121 (3) ◽  
pp. 327-328
Author(s):  
V. V. Svishchenko ◽  
E. D. Gol'dberg
Keyword(s):  
Cell Death ◽  
Erythropoietic System

Erythropoietic recovery and residual injury in rats exposed repeatedly to x-rays

1961 ◽  
Vol 200 (1) ◽  
pp. 155-158 ◽  
Author(s):  
Siegmund J. Baum
Keyword(s):  
Stem Cells ◽  
Functional Capacity ◽  
Iron Uptake ◽  
Normal Values ◽  
Cell Damage ◽  
Recovery Period ◽  
Red Cell ◽  
X Rays ◽  
Rate Of Recovery ◽  
Erythropoietic System

Rats exposed repeatedly to 300-r x-rays showed a decrease in Fe59 incorporation which attained its lowest point 48 hours postirradiation. Thereafter iron uptake increased until normal values were measured. This return to normalcy was delayed further with each newly repeated irradiation. On any day during the recovery period Fe59 uptake decreased exponentially with repeated x-irradiations. This decrease is a measure of residual injury to the erythropoietic system. Since, after each repeated irradiation, a reduced amount of Fe59 was incorporated at the beginning of the recovery period, while the rate of recovery was similar, it is postulated that the decrease in radio iron uptake is due to an impairment in the functional capacity of the stem cells to proliferate erythrocytes. A working hypothesis for the calculation of erythrocyte stem cell damage is presented. Although the functional capacity of the stem cells to produce erythrocytes was reduced, the daily red cell turnover was normal. Only when this reduction was below a certain limit did a permanent anemia ensue.

The effect of radioprotective agents on erythropoiesis In irradiated mice

1969 ◽  
Vol 47 (1) ◽  
pp. 65-71
Author(s):  
P. V. Vittorio ◽  
E. A. Watkins ◽  
S. Dziubalo-Blehm
Keyword(s):  
Good Method ◽  
Reduction Factor ◽  
Poor Correlation ◽  
Early Recovery ◽  
Control Value ◽  
Degree Of Protection ◽  
Fe Uptake ◽  
Erythropoietic System ◽  
Survival Studies ◽  
Radioprotective Agent

The radioiron test (i.e. 59Fe uptake by blood, spleen, and liver) was used to evaluate the degree of protection (1 day after irradiation) and effect on recovery (7 days after irradiation) of the erythropoietic system when radioprotective agents were administered. In blood, spleen, and liver, AET administered prior to irradiation caused a decreased radiation effect on 59Fe uptake 1 day after irradiation, and a subsequent parallel return with the irradiated nonprotected group to the control value. This indicated that the early recovery by the protected group was probably due to less initial damage. The amount of protection afforded the erythropoietic system by sulfhydryl agents was in good agreement with irradiation survival studies and indicated that a good sulfhydryl radioprotective agent provided good protection, and a poor sulfhydryl radioprotective agent provided poor protection to the erythropoietic system. Thus the radioiron test is a good method to evaluate sulfhydryl compounds as radioprotective agents. Endotoxin demonstrated poor correlation between the early (1 day) erythropoietic effect and survival in irradiated mice, but recovery studies (7 days) showed much better agreement. The biological amine serotonin produced poorer initial protection to the erythropoietic system and slower recovery than AET even though the dose reduction factor of each was comparable. Serotonin must, therefore, protect other systems which then contribute to the eventual recovery of the erythropoietic system, and survival.

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