Effects of Azathioprine and Mycophenolate Mofetil—Immunosuppressive Regimens on the Erythropoietic System of Renal Transplant Recipients

2006 ◽  
Vol 38 (7) ◽  
pp. 2077-2079 ◽  
Author(s):  
H.T. Khosroshahi ◽  
A. Asghari ◽  
R. Estakhr ◽  
B. Baiaz ◽  
M.R. Ardalan ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Erythropoietic System

Mycophenolate mofetil immunosuppression in high-risk renal transplant recipients

1998 ◽  
Vol 30 (8) ◽  
pp. 4077-4078
Author(s):  
G.M Abouna ◽  
A.S Al Arrayed ◽  
E Farid ◽  
C.K Awad ◽  
S.A-D Sharqawi ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
High Risk ◽  
Renal Transplant ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Erythrocyte sodium lithium countertransport in renal transplant recipients with mycophenolate mofetil and low-dose cyclosporine

2004 ◽  
Vol 36 (10) ◽  
pp. 3032-3035
Author(s):  
K. Vareesangthip ◽  
P. Hanlakorn ◽  
L. Suwannaton ◽  
R. Larpkitkachorn ◽  
D. Chuawattana ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Low Dose ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Erythrocyte Sodium

P1664ASSOCIATED WITH SERUM MYOSTATIN LEVEL WITH GAIT SPEED IN RENAL TRANSPLANT RECIPIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Chi-Chong Tang ◽  
Jia-Sian Hou ◽  
Yu-Chi Chang ◽  
Chia-Wen Lu ◽  
Ming-Che Lee ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Mycophenolate Mofetil ◽  
Renal Transplant ◽  
Gait Speed ◽  
Filtration Rate ◽  
Walking Speed ◽  
Estimated Glomerular Filtration Rate ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Speed Test

Abstract Background and Aims Walking speed test is a usefulness tool for cardiovascular risk stratification in older adults. The inhibition of myostatin in adult significantly increases muscle mass and confers benefits upon measures of performance and metabolism. The present study evaluated the relationship between walking speed test and serum myostatin levels in renal transplant recipients. Method Fasting blood samples were collected from 84 renal transplant recipients. Handgrip strength (HGS) was measured using a Jamar Plus Digital Hand Dynamometer for assessment of muscle strength. Gait speed was measured by walking 6 meters at the usual speed. Gait speed < 1 m/s was defined as low gait speed group according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Serum myostatin levels were measured using a commercial enzyme-linked immunosorbent assay. Results Thirty-one renal transplant recipients (36.9%) had low gait speed, and they included a lower percentage of use of mycophenolate mofetil (p = 0.003), higher percentage of use of steroid (p = 0.037), older age (p = 0.0090, higher body weight (p = 0.044), body mass index (p = 0.017), skeletal muscle index (p = 0.027), serum triglyceride (p = 0.029), glucose (p = 0.007), blood urea nitrogen (p = 0.041), cystatin C (p = 0.015), while lower estimated glomerular filtration rate from serum creatinine (eGFRcre, p = 0.047) and estimated glomerular filtration rate from serum cystatin C (eGFRcys, p = 0.006) compared with renal transplant recipients with normal gait speed. After adjusting for cofounders associated with low gait speed in these patients by multivariable logistic regression analysis, serum myostatin levels (Odds ratio (OR): 0.943, 95% confidence interval (CI): 0.898–0.990, p = 0.018), and mycophenolate mofetil used (OR: 0.199, 95% CI: 0.050–0.795, p = 0.022) were independently associated with low gait speed in renal transplant recipients. The area under the receiver-operating characteristic (ROC) curve indicates the diagnostic power of serum myostatin levels at predicting low gait speed of renal transplant recipients was 0.769 (95% CI: 0.664-0.854, p < 0.001). Multivariable forward stepwise linear regression analysis also showed that serum myostatin levels (β = 0.353, adjusted R2 change: 0.245, p = 0.001) was positively associated with gait speed values in renal transplant recipients. Conclusion In this study, serum myostatin levels is found to be positively correlated with gait speed values and is identified as serum low myostatin levels is associated with low gait speed in renal transplant patients.

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