Comparative effects of carprofen, benoxaprofen and indomethacin on the development and decay phases of a carrageenan pleurisy in the rat

1984 ◽  
Vol 14 (5-6) ◽  
pp. 667-672 ◽  
Author(s):  
D. Bradshaw ◽  
P. H. Franz ◽  
S. J. Greenham
Keyword(s):  
Carrageenan Pleurisy

scholarly journals The aspects of free radical oxidation in the lungs of rats with pleurisy under long-term lighting

2017 ◽  
Author(s):  
O. M. Larycheva ◽  
L. D. Chebotar ◽  
T. Ya. Yaroshenko
Keyword(s):  
Free Radical ◽  
Electron Transport ◽  
Pineal Gland ◽  
Light Exposure ◽  
Free Radical Oxidation ◽  
Control Group ◽  
Ros Generation ◽  
Radical Oxidation ◽  
Carrageenan Pleurisy

Introduction.Pathological changes in human body due to light exposure at night are triggered by circadian disruption, inhibition of melatonin secretion by the pineal gland at night that leads to its reduction in blood. Clinical and experimental data indicate high importance of free radical oxidation inthe pathogenesis of pulmonary diseases. The aim of the study – to explore the influence of a melatonin deficiencyin addition to pleurisy on free radical oxidation in the tissues of the lungs of rats exposed to light for 30 days.Research Methods. Experiments were carried out on male albino Wistar rats. The animals were randomized into four groups with 7 animals in each: an intact group, 30 day pineal gland hypofunction, carrageenan pleurisy, 30 day pineal gland hypofunction with carrageenan pleurisy. Pineal gland hypofunction was modeled by 1500 lx fluorescent lamps around the clock. The experimental pleurisy was induced in anesthetized animals by intrapleural injection of 0.1 ml of carrageenan. Superoxide (•О2-) products were determined by the reaction with nitro blue tetrazolium under the influence of NADH, NADP and pirogenal. The concentration of diene conjugates was determined by I.D. Stalna technique, TBA-active products – by I.D. Stalna, T.H. Harishvili method, trienes, ketodienes, - by a modified method based on the molar extinction coefficient.Results and Discussion.Assessingthe intensity of the reactive oxygen species (ROS) generation, a significantincrease of the •О2-level in all sources of its generation in the tissues of the lungs has been observed both in the control group with pleurisy and in the rats with 30-day pineal gland hypofunctionandpleurisy, compared to the intact animals.The chronic pineal gland hypofunction in the animals with experimental pleurisy lead to •О2- generationby the microsomal electron transport chain (ETC) by 54.6 % (р<0.05) when compared with carrageenan group of rats. No significant changes in concentration of the lipid peroxidation products has been observed in the animals with pleurisy during long-term light exposure.Conclusions. Chronic hypofunction of the pineal gland with the carrageenan-induced pleurisy causes activation of the free radical processes in the rats’ lung tissues and occur as hyperproduction of the superoxide anion radical by the microsomal chain of oxidation. This fact denotes probable abnormalities in the function of the microsomal electron transport chains especially under the condition change of properties of dehydrogenases. 

Changes of Cu & Zn in carrageenan pleurisy and paw-oedema in rat

1988 ◽  
Vol 20 (7) ◽  
pp. 629-630 ◽  
Author(s):  
M. Marrella ◽  
U. Moretti ◽  
E. Concari ◽  
G.P. Velo ◽  
R. Milanino
Keyword(s):  
Paw Oedema ◽  
Carrageenan Pleurisy

Development of Carrageenan Pleurisy in the Rat: Effects of Colchicine on Inhibition of Cell Mobilization

1981 ◽  
Vol 168 (1) ◽  
pp. 24-32 ◽  
Author(s):  
R. Vinegar ◽  
J. F. Truax ◽  
J. L. Selph ◽  
P. R. Johnston ◽  
A. L. Venable ◽  
...  
Keyword(s):  
Cell Mobilization ◽  
Carrageenan Pleurisy

Effect of various NSAID and a steroid on carrageenan pleurisy in the rat

1985 ◽  
Vol 7 (3) ◽  
pp. 395
Author(s):  
D. Bradshaw ◽  
B.B. Dodge ◽  
P.H. Franz
Keyword(s):  
Carrageenan Pleurisy

Anti-inflammatory effects of LPS, MDP and FMLP on carrageenan pleurisy in the rat

1994 ◽  
Vol 41 (1-2) ◽  
pp. 53-56 ◽  
Author(s):  
C. A. Allen ◽  
D. M. Ferry ◽  
V. S. Chadwick
Keyword(s):  
Anti Inflammatory ◽  
Carrageenan Pleurisy
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