Local anti-inflammatory activity of steroid-21-oate esters in the carrageenan pleurisy model of acute inflammation

1989 ◽  
Vol 17 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Ann S. Heiman ◽  
Irach B. Taraporewala ◽  
Henry J. Lee
Keyword(s):  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Carrageenan Pleurisy

scholarly journals EVALUATION OF EFFECT OF AQUEOUS EXTRACT OF PORTULACA OLERACEA LINN. LEAVES IN ACUTE INFLAMMATION

2020 ◽  
pp. 1-2
Author(s):  
M. Medhabati ◽  
L. Babycha ◽  
L. Tarinita ◽  
Bikram Tewari ◽  
Saumya Kanti Sinha
Keyword(s):  
Aqueous Extract ◽  
Acute Inflammation ◽  
Portulaca Oleracea ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Standard Drug ◽  
Paw Oedema ◽  
The Mean ◽  
Anti Inflammatory ◽  
Inflammatory Action

In the present study, the anti-inflammatory activity of aqueous extract of Portulaca oleracea (POE 200, 400 and 600mg/kg) was studied using carrageenan induced paw oedema in albino rats. The mean increase in paw volume was recorded. POE produced significant (p<,0.01) anti-inflammatory activity when compared to the control. The anti-inflammatory action of POEcan be attributed to its flavonoid contents which are known to act through inhibition of prostaglandin biosynthesis. However, the test drug at maximum dose (600mg/kg) was found to be less effective than the standard drug, aspirin (100mg/Kg).

The Anti-inflammatory Effect of Polyphenolics Olive Leaf Extracts Olea europaea L.

2021 ◽  
Author(s):  
Y. Aissaoui ◽  
Y. Boukhari ◽  
M. A. Mahi
Keyword(s):  
Olea Europaea ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Olive Leaves ◽  
Leaf Extracts ◽  
Polyphenolic Extract ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
Inflammatory Effect ◽  
Olea Europaéa

This study was to evaluate the anti-inflammatory effect of the polyphenolic extract of olive leaves Olea europaea L. In vivo experiments were performed on the model of acute inflammation edema of the paw of male Wistar rats following inflammation induced by the injection of carrageenan. The anti-inflammatory effect is carried out by the injection of the polyphenolic extracts of olive leaves Olea europaea L. at different doses 50 mg/kg, 100 mg/kg and 150 mg/kg, the injection was carried out 30 min before induction of acute inflammation with carrageenan at 1%. The results obtained were compared with those of Diclofenac and those of the physiological control. Injection of carrageenan resulted in a significant increase in the claw leg volume of 46.24 ± 23.8%, 66.78 ± 29.69% and 90.31 ± 46.51%, respectively at 1 h, 2 h, and 3 h. The results showed that the inflammatory activity of the polyphenolic extracts of olive leaves was dose dependent. The 150 mg/kg Olea europaea L. extract of polyphenolic has an anti-inflammatory activity which results in an 88% decrease in edema. This decrease is significantly similar to that of Diclofenac® 97% confirmed that the polyphenolic extracts of Olea europaea L. leaves have anti-inflammatory activities comparable to that of Diclofenac® with a non-significant difference (p < 0.05), this anti-inflammatory effect remains lower than that of Diclofenac®.

HYDRO-ALCOHOLIC EXTRACT OF THEVETIA PERUVIANA ATTENUATES ACUTE AND SUB-ACUTE INFLAMMATION: AN IN VITRO STUDY

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (06) ◽  
pp. 33-37
Author(s):  
N. K Choudhary ◽  
◽  
V Sharma ◽  
S Goyal ◽  
M. S Panwar ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Protein Denaturation ◽  
In Vitro Study ◽  
In Vitro Models ◽  
Vitro Study ◽  
Inflammatory Activity ◽  
Alcoholic Extract ◽  
Thevetia Peruviana ◽  
Anti Inflammatory

The main aim of the study was to carry out anti-inflammatory activity of Thevetia peruviana in acute and sub acute in vitro models. The hydro-alcoholic extract showed the presence of carbohydrate, tannins, flavonoids, terpenes, steroids, glycosides and alkaloids. Against protein denaturation, the model extract showed 85% inhibition at a concentration of 100μg/mL. Similarly the extract showed 70.55% protection of RBC haemolysis as compared with 74.78% produced by indomethacin.

scholarly journals The Anti-Inflammatory Activity of Nigella sativa Balm Sticks

2019 ◽  
Vol 87 (1) ◽  
pp. 3 ◽  
Author(s):  
Lusi Dwita ◽  
Kori Yati ◽  
Sri Gantini
Keyword(s):  
Topical Application ◽  
Acute Inflammation ◽  
Nigella Sativa ◽  
Inflammatory Activity ◽  
Nigella Sativa Oil ◽  
Paw Oedema ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Anti Inflammation

Nigella sativa oil has been known to have potent anti-inflammatory activity. This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simple balm stick by topical application. The activity was checked using two methods: carrageenan-induced paw oedema and granuloma pouch on rats. The results showed that balm sticks which contained 10% Nigella sativa could overcome both acute and sub-acute inflammation showing by high oedema inhibition (60.64%), low leucocytes count (43.55% lower than control) as well as a notable TNF-α concentration (50% lower than control) on the inflamed area. In conclusion, topical application of a Nigella sativa balm stick was effective for both acute and sub-acute forms of inflammation.

scholarly journals Anti-inflammatory Activity of Piperlotines

2020 ◽  
Vol 64 (3) ◽  
Author(s):  
OscarAbelardo Ramírez-Marroquín ◽  
María Adelina Jiménez-Arellanes ◽  
Julieta Luna-Herrera ◽  
José Luis Olivares-Romero ◽  
Israel Bonilla-Landa ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Acute Inflammation ◽  
Inflammatory Diseases ◽  
Reaction Times ◽  
Antimycobacterial Activity ◽  
Topical Administration ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Valuable Compounds

Abstract. In the present study we evaluated six α,β-unsaturated amides named piperlotines (for being isolated originally from Piper species) as new in vivo anti-inflammatory agents. In addition, we report the mechanosynthesis of two of them by mechanochemical activation of a Horner-Wadsworth-Emmons reaction. The reaction of β-amidophosphonate 4, an aromatic aldehyde and K2CO3 under grinding in a mortar and pestle afforded piperlotines 5-6 in good yields (70-88%) in short reaction times, obtaining only (E)-diastereomer. Piperlotines previously prepared were tested as anti-inflammatory and antibacterial agents. In this respect, derivatives 2 and 6 exhibited excellent in vivo anti-inflammatory activity on mice, especially trough topical administration (TPA acute inflammation model). Furthermore, piperlotine A, and compounds 2 and 6 had slight antimycobacterial activity against Mycobacterium tuberculosis (MIC = 50 µg/mL). In conclusion, the solvent-free mechanosynthesis of piperlotines produced valuable compounds that could serve as templates for further investigation in the search of better drug-like compounds for the treatment of inflammatory diseases.   Resumen. En la presente investigación se evaluó la actividad anti-inflamatoria in vivo de seis amidas α,β-insaturadas, identificadas en la literatura como piperlotinas debido a su inicial aislamiento a partir de especies vegetales del género Piper (como las pimientas). La reacción del β-amidofosfonato 4 con un aldehído aromático y K2CO3 en molienda con mortero y pistilo produjo las piperlotinas 5-6 con buenos rendimientos (70-80%) en tiempos cortos de reacción, obteniendo solamente el diastereoisómero (E). Las piperlotinas preparadas se evaluaron como agentes anti-inflamatorios y antibacterianos, observando excelente actividad anti-inflamatoria para los derivados 2 y 6, especialmente cuando se probaron mediante administración tópica (modelo de inflamación aguda por TPA). Además, la piperlotina A y los derivados 2 y 6 mostraron actividad antibacteriana contra Mycobacterium tuberculosis (MIC = 50 µg/mL). En conclusión, la síntesis de piperlotinas a través de molienda en condiciones libres de disolvente generó importantes productos que pueden ser utilizados como punto de partida para generar nuevos compuestos bioactivos para el tratamiento de padecimientos relacionados con la inflamación.

Evidence of anti-inflammatory activity of Schizandrin A in animal models of acute inflammation

2020 ◽  
Vol 393 (11) ◽  
pp. 2221-2229 ◽  
Author(s):  
Likun Cui ◽  
Wenzhe Zhu ◽  
Zhijie Yang ◽  
Xiyuan Song ◽  
Cui Xu ◽  
...  
Keyword(s):  
Animal Models ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Anti-Inflammatory Activity of Licochalcone A Isolated from Glycyrrhiza inflata

2008 ◽  
Vol 63 (5-6) ◽  
pp. 361-365 ◽  
Author(s):  
Yongming Cui ◽  
Mingzhang Ao ◽  
Jing Hu ◽  
Longjiang Yu
Keyword(s):  
Acute Inflammation ◽  
Inflammatory Activity ◽  
Mouse Macrophage ◽  
Paw Edema ◽  
Prostaglandin Biosynthesis ◽  
Licochalcone A ◽  
Ear Edema ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Glycyrrhiza Inflata

Licochalcone A was isolated from the roots of Glycyrrhiza inflata and evaluated for its anti-inflammatory activity in xylene-induced mice ear edema and carrageenan-induced paw edema tests. At the same time, the inhibition of prostaglandin biosynthesis by licochalcone A was also studied in lipopolysaccharide (LPS)-induced mouse macrophage cells. At 5 mg/ ear, licochalcone A showed remarkable effects against acute inflammation induced by xylene, and at the doses of 2.5, 5, 10 mg/kg (p.o.), licochalcone A reduced significantly paw edema induced by carrageenan compared to the control at the fourth hour. Both COX-2 activity and expression were significantly inhibited by licochalcone A at all the test doses. Therefore, licochalcone A could be a useful compound for the development of new anti-inflammatory agents.

scholarly journals Evaluation of anti-inflammatory activity of ethanolic extract of Gmelina arborea in experimental acute and sub-acute inflammatory models in wistar rats

2018 ◽  
Vol 8 (1) ◽  
pp. 128
Author(s):  
Priya Gandigawad ◽  
Basavaraj Poojar ◽  
Nandan Hodlur ◽  
Ravi K. Sori
Keyword(s):  
Wistar Rats ◽  
Acute Inflammation ◽  
Inflammatory Activity ◽  
High Dose ◽  
Root Extract ◽  
Paw Edema ◽  
Gmelina Arborea ◽  
Standard Drug ◽  
Inflammatory Models ◽  
Anti Inflammatory

Background: Inflammation is a complex reaction to various injurious agents such as infections, trauma, foreign bodies, tissue necrosis, physical and chemical agents, that consists of vascular responses, migration and activation of leukocytes and systemic reactions. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are currently the most commonly prescribed drugs for treating pain and inflammation. The traditional NSAIDs usually cause various adverse effects on long term use. Gmelina arborea Linn (Gambhari) belongs to family Verbenaceae. The roots, leaves, flowers, fruits and bark are used for treating different ailments as anthelmintic, analgesic, anti-pyretic, antidiabetic, antimicrobial, diuretic and other common disorders.Methods: The study was carried out by using inflammatory models in wistar rats. The anti-inflammatory activity of G. arborea was compared with standard drug aspirin. The study parameters for acute inflammation was assessment of reduction in inflammation & the percentage inhibition of the paw edema. The parameter for the sub-acute inflammation was percentage inhibition of the dry granuloma weight.Results: The low and high dose of G. arborea root extract significantly showed the anti-inflammatory activity when compared to control group. The high dose of G. arborea extract showed comparable results in parameters like reducing inflammation, percentage inhibition of paw edema and dry granuloma weight in acute carrageenan paw edema and sub-acute inflammation cotton pellet granuloma models with standard aspirin treated group.Conclusions: Since G. arborea root extract was having all the qualities required for anti-inflammatory drug. However, no clear inference can be drawn at this stage and hence we consider the work for further extensive research.

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