Decrease in peritoneal mast cell count in rats with adjuvant arthritis. II. inhibition by anti-inflammatory and immunosuppressive drugs

1980 ◽  
Vol 10 (4) ◽  
pp. 317-321 ◽  
Author(s):  
Saiichirou Seo
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
Adjuvant Arthritis ◽  
Immunosuppressive Drugs ◽  
Peritoneal Mast Cell ◽  
Mast Cell Count ◽  
Anti Inflammatory

scholarly journals High fat diet and mast cell count in rat mesenterium

1958 ◽  
Vol 14 (5) ◽  
pp. 184-184 ◽  
Author(s):  
J. Fodor ◽  
P. Fábry ◽  
Z. Lojda
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
High Fat Diet ◽  
High Fat ◽  
Mast Cell Count

scholarly journals Increased Mast Cell Counts and Degranulation in Microscopic Colitis

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Zhikai Chi ◽  
Jing Xu ◽  
Romil Saxena
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
Cell Activation ◽  
Collagenous Colitis ◽  
Microscopic Colitis ◽  
Mast Cell Activation ◽  
Mucosal Inflammation ◽  
High Power Field ◽  
Cell Counts ◽  
Mast Cell Count

Objectives. Microscopic colitis (MC) is characterized by chronic diarrhea, normal colonoscopy findings, and mucosal inflammation in colonic biopsies and can be classified as collagenous colitis (CC) or lymphocytic colitis (LC). However, the pathogenesis of MC is largely unknown. In this study, we aimed to study mast cell counts and activation in MC. Methods. We investigated 64 biopsy samples from the surgical pathology database of Indiana University Health, which met the diagnostic criteria for CC or LC along with 20 control samples collected from 2014 to 2015. The specimens were used for the quantification of mast cells by examining the presence of intracellular and extracellular tryptase by immunohistochemistry. Results. In the lamina propria, the mast cell count was higher in both CC and LC groups than the control (mean highest count, 39/high-power field (HPF) vs. 30/HPF vs. 23/HPF; P<0.01). Extracellular tryptase was present in 10% of control subjects as compared to 41% of CC (P<0.05) and 60% of LC (P<0.001) patients. When LC patients were stratified into two groups with either <80% or >80% of fragments affected by inflammation, increased mast cell counts are only observed in the >80% involvement group compared with the control, but not the <80% involvement group. Conclusions. The increased mast cell count and degranulation are identified in MC, suggesting that mast cell activation might be involved in the pathogenesis of MC.

SKIN HEPARIN LEVELS AND POSTHEPARIN PLASMA CLEARING FACTOR LIPASE LEVELS IN IRRADIATED ADRENALECTOMIZED AND CORTISONE-TREATED RATS

1963 ◽  
Vol 41 (1) ◽  
pp. 1901-1906
Author(s):  
Frank C. Monkhouse ◽  
Donald G. Baker
Keyword(s):  
Mast Cell ◽  
Plasma Levels ◽  
Peritoneal Mast Cell ◽  
Rat Tissues ◽  
Cell Counts ◽  
X Irradiation ◽  
Mast Cell Count ◽  
Significant Change ◽  
Total Body ◽  
Adrenalectomized Rats

Experiments were carried out to determine whether changes in endogenous heparin in rat tissues were related to changes in plasma levels of clearing factor lipase (CFL). Skin heparin levels, postheparin plasma CFL levels, and peritoneal mast cell counts were measured in normal, adrenalectomized, cortisone-treated, and X-irradiated rats. Total body X-irradiation in doses of 400 r to 600 r decreased skin heparin levels. The postheparin CFL levels of irradiated rats remained high while that of pair-fed controls dropped significantly. Cortisone treatment for 6 days caused an increase in plasma CFL levels in both intact and adrenalectomized rats but no significant change in skin heparin levels or mast cell count. Adrenalectomy caused no significant change in either postheparin CFL or skin heparin levels.

scholarly journals Morphometric study of the fibrosis and mast cell count in the circular colon musculature of chronic Chagas patients with and without megacolon

2003 ◽  
Vol 36 (4) ◽  
pp. 461-466 ◽  
Author(s):  
Simone Wanderley Pinheiro ◽  
Adilha Misson de Oliveira Rua ◽  
Renata Margarida Etchebehere ◽  
Cristiane Gobbo Cançado ◽  
Javier Emílio Lazo Chica ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
Fibrous Tissue ◽  
Morphometric Study ◽  
Significant Difference ◽  
Mast Cell Count ◽  
Distal Sigmoid

A morphometric study of the circular colon musculature was performed, in which the mast cell count was determined and the connective fibrous tissue in this layer was measured. The objective was to gain better understanding of Chagas megacolon morphology and contribute towards the knowledge of fibrosis pathogenesis in Chagas megas. An evaluation was made of 15 distal sigmoid rings from Chagas patients with megacolon (MCC), 15 without megacolon (CSMC) and 15 non-Chagas patients (NC). The rings were fixed in formol, embedded in paraffin, and 7mm thick sections were cut and stained using Azan-Heidenhain and Giemsa. The mast cell count and fibrosis were greater in the MCC group than in the CSMC and NC groups (p < 0.05; Kruskal-Wallis test) and there was no significant difference between the latter two. The fibrosis and increased mast cell count in the colon musculature of the MCC group possibly indicates that there is a relationship between mastocytosis and fibrosis, as has already been demonstrated in other pathologies.

scholarly journals Correlation between testicular mast cell count and spermatogenic epithelium in non-obstructive azoospermia

2018 ◽  
Vol 99 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Ahmed A. M. Abdel-Hamid ◽  
Hoda Atef ◽  
Khaled R. Zalata ◽  
Atef Abdel-Latif
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
Obstructive Azoospermia ◽  
Mast Cell Count ◽  
Spermatogenic Epithelium

scholarly journals Does cystoscopy method affect the investigation of bladder pain syndrome/interstitial cystitis?

2020 ◽  
Author(s):  
Visha K. Tailor ◽  
Ellen Morris ◽  
Alka A. Bhide ◽  
Ruwan Fernando ◽  
Guiseppe A. Digesu ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
Interstitial Cystitis ◽  
Muscularis Propria ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Detrusor Muscle ◽  
Bladder Pain ◽  
Significant Difference ◽  
Mast Cell Count

Abstract Introduction and hypothesis Cystoscopic investigation to identify associated histological findings of increased mast cells in the detrusor muscle has been recommended by the European Society for the Study of Bladder Pain Syndrome (ESSIC) in the investigation of bladder pain syndrome/interstitial cystitis (BPS/IC). The aim of this study was to identify if the cystoscopy approach impacts the biopsy results when investigating women presenting with symptoms of BPS/IC. Methods We performed a single-centre retrospective analysis of 300 bladder biopsy reports from 2015 to 2018 from women undergoing cystoscopy for BPS/IC. Biopsies obtained using closed cup forceps through a flexible (FC) or rigid cystoscope (RC) were compared. Results Fifty-eight FC biopsies were compared with 242 RC biopsies. FC biopsies had a smaller mean diameter (1.6 mm vs 2.9 mm p < 0.01) and volume (4.1 mm3 vs 9.6 mm3p < 0.001) compared with RC biopsies. There was no significant difference in the histological depth of sampling to the muscularis propria. A total of 292 samples had CD117 immunohistochemical staining for mast cell count (MCC) analysis. The MCC/mm2 was significantly lower in FC biopsies (p < 0.01). Sixteen percent of FC samples compared with 60% of RC samples had a high MCC >28/mm2 (p < 0.01). There was no significant difference in positive microbiology culture between FC (21%) and RC (28%) sampling. Conclusion Rigid and flexible cystoscopy can be used to investigate BPS/IC as recommended by international societies. However, the biopsy method impacts the mast cell count analysis, which can influence diagnosis and management. Therefore, RC would be the optimal investigation.

scholarly journals Analysis of colonic mucosa mast cell count in patients with chronic diarrhea

2012 ◽  
Vol 18 (5) ◽  
pp. 322 ◽  
Author(s):  
Ali Zare-Mirzaie ◽  
Maryam Lotfi ◽  
Alireza Sadeghipour ◽  
Mohammad-Taghi Haghi-Ashtiani
Keyword(s):  
Mast Cell ◽  
Cell Count ◽  
Colonic Mucosa ◽  
Chronic Diarrhea ◽  
Mast Cell Count
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