The effects of 4-imidazolyl-3-amino-2-butanone (McN-A-1293), a specific histidine decarboxylase inhibitor, on the expression of morphine tolerance and physical dependence in mice

1977 ◽  
Vol 7 (2) ◽  
pp. 237-239
Author(s):  
Chak-Lam Wong ◽  
Michael B. Roberts
Keyword(s):  
Histidine Decarboxylase ◽  
Physical Dependence ◽  
Morphine Tolerance ◽  
Decarboxylase Inhibitor

Treatment of two mastocytosis patients with a histidine decarboxylase inhibitor

1985 ◽  
Vol 16 (3-4) ◽  
pp. 244-248 ◽  
Author(s):  
G. Granerus ◽  
J. H. Olafsson ◽  
G. Roupe
Keyword(s):  
Histidine Decarboxylase ◽  
Decarboxylase Inhibitor

scholarly journals The Role of CGRP in the Development of Morphine Tolerance and Physical Dependence

2001 ◽  
Vol 1 ◽  
pp. 21-21
Author(s):  
K. J. Powell ◽  
T. Trang ◽  
R. Quirion ◽  
K. Jhamandas
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat

1994 ◽  
Vol 25 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Hemendra N. Bhargava ◽  
George A. Matwyshyn ◽  
Phillip M. Gerk ◽  
Pamela S. Bozek ◽  
Melissa D. Bailey ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

scholarly journals Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats

2018 ◽  
Vol 17 (1) ◽  
pp. 138-143
Author(s):  
Siti Norhajah Hashim ◽  
Nasir Mohamad ◽  
Zulkifli Mustapha ◽  
Nor Hidayah Abu Bakar ◽  
Rohayah Husain ◽  
...  
Keyword(s):  
Analgesic Effect ◽  
Physical Dependence ◽  
Medical Science ◽  
Morphine Tolerance ◽  
Morphine Dependence ◽  
P Value ◽  
Concomitant Treatment ◽  
Sprague Dawley ◽  
Chronic Morphine ◽  
Analgesic Tolerance

Introduction:Honey has been used traditionally in medicine as well as food supplements. Honeybees are said to be able to cure many diseases. However, its influences on opioid tolerance and dependence have not yet been clarified.Materials and Methods:Adult male Sprague- Dawley rats were rendered tolerant to the analgesic effect of morphine by injection of morphine (10 mg/kg, i.p.) twice daily for 14 days. To develop morphine dependence rats given escalating doses of chronic morphine. To determine the effect of stingless bee honey on the development of morphine tolerance and dependence. The hotplate and naloxone precipitation tests were used to assess the degree of tolerance and dependence, respectively.The results: Our results showed that chronic morphine-injected rats displayed tolerance to the analgesic effect of morphine as well as morphine dependence. Methadone+morphine (MetM), methadone+morphine+ honey (MetMH) and morphine+Honey (MH) significantlylower the development of morphine tolerance with p-value p<0.05. In addition, concomitant treatment of morphine with MH and MetMH attenuated almost all of the naloxone-induced withdrawal signs which include abdominal contraction, diarrhea, pertussis, teeth chattering, and jumping.Conclusion: The data indicate that honey has a potential to reduce tolerant and dependence property.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.138-143

The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence

1997 ◽  
Vol 355 (2) ◽  
pp. 281-287 ◽  
Author(s):  
P.-L. Tao ◽  
Wan-Cherng Liu ◽  
Yuan-Sheng Tsuei ◽  
Chen-Yu Cheng
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance
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