scholarly journals The Role of CGRP in the Development of Morphine Tolerance and Physical Dependence

2001 ◽  
Vol 1 ◽  
pp. 21-21
Author(s):  
K. J. Powell ◽  
T. Trang ◽  
R. Quirion ◽  
K. Jhamandas
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence

1997 ◽  
Vol 355 (2) ◽  
pp. 281-287 ◽  
Author(s):  
P.-L. Tao ◽  
Wan-Cherng Liu ◽  
Yuan-Sheng Tsuei ◽  
Chen-Yu Cheng
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice

2020 ◽  
pp. 1-7
Author(s):  
Zeynep Cetin ◽  
Ozgur Gunduz ◽  
Ruhan D. Topuz ◽  
Dikmen Dokmeci ◽  
Hakan C. Karadag ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Physical Dependence ◽  
Morphine Tolerance ◽  
Morphine Dependence ◽  
Tail Flick ◽  
Pain Mechanisms ◽  
Antinociceptive Effects ◽  
Synthase Inhibitor ◽  
Development Of Tolerance

<b><i>Objective:</i></b> Hydrogen sulfide is an endogenous gaseous mediator that has been indicated to have a role in pain mechanisms. In this study, we aimed to detect brain and spinal cord hydrogen sulfide levels during different phases of tolerance and dependence to morphine and to determine the effects of inhibition of endogenous hydrogen sulfide production on the development of tolerance and dependence. <b><i>Methods:</i></b> Morphine tolerance and dependence was developed by subcutaneous injection of morphine (10 mg/kg) twice daily for 12 days. Physical dependence was determined by counting the jumps for 20 min, which is a withdrawal symptom occurring after a single dose of naloxone (5 mg/kg) administered intraperitoneally (i.p.). Propargylglycine (30 mg/kg, i.p.), a cystathionine-γ-lyase inhibitor, and hydroxylamine (12.5 mg/kg, i.p.), a cystathionine-β-synthase inhibitor, were used as hydrogen sulfide synthase inhibitors. The tail-flick and hot-plate tests were used to determine the loss of antinociceptive effects of morphine and development of tolerance. <b><i>Results:</i></b> It was found that chronic and acute uses of both propargylglycine and hydroxylamine prevented the development of tolerance to morphine, whereas they had no effect on morphine dependence. Chronic and acute administrations of hydrogen sulfide synthase inhibitors did not exert any difference in hydrogen sulfide levels in brain and spinal cords of both morphine-tolerant and -dependent animals. <b><i>Conclusion:</i></b> It has been concluded that hydrogen sulfide synthase inhibitors may have utility in preventing morphine tolerance.

Possible role of cyclic AMP and dopamine in morphine tolerance and physical dependence

Life Sciences ◽  
1975 ◽  
Vol 16 (12) ◽  
pp. 1883-1888 ◽  
Author(s):  
Chander S. Mehta ◽  
Willam E. Johnson
Keyword(s):  
Cyclic Amp ◽  
Physical Dependence ◽  
Morphine Tolerance

The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence

2019 ◽  
Vol 512 (3) ◽  
pp. 460-466 ◽  
Author(s):  
Shuo Li ◽  
Ning Wu ◽  
Tai-Yun Zhao ◽  
Guan-Yi Lu ◽  
Zhi-Yuan Wang ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

Yokukansan inhibits morphine tolerance and physical dependence in mice: The role of α2A-adrenoceptor

Neuroscience ◽  
2012 ◽  
Vol 227 ◽  
pp. 336-349 ◽  
Author(s):  
T. Nakagawa ◽  
K. Nagayasu ◽  
N. Nishitani ◽  
H. Shirakawa ◽  
K. Sekiguchi ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

Role of P2X7 Receptor-Mediated IL-18/IL-18R Signaling in Morphine Tolerance: Multiple Glial-Neuronal Dialogues in the Rat Spinal Cord

2012 ◽  
Vol 13 (10) ◽  
pp. 945-958 ◽  
Author(s):  
Meng-Ling Chen ◽  
Hong Cao ◽  
Yu-Xia Chu ◽  
Long-Zhen Cheng ◽  
Ling-Li Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
P2x7 Receptor ◽  
Morphine Tolerance ◽  
Rat Spinal Cord
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