The inhibition of salivary secretion by histamine H2-antagonists—a study on the cat submandibular gland

1983 ◽  
Vol 13 (2-3) ◽  
pp. 196-199 ◽  
Author(s):  
L. Stanovnik ◽  
F. Erjavec
Keyword(s):  
Submandibular Gland ◽  
Salivary Secretion ◽  
H2 Antagonists ◽  
Histamine H2 Antagonists

A neurokinin-1 receptor antagonist reduced hypersalivation and gastric contractility related to emesis in dogs

1998 ◽  
Vol 275 (5) ◽  
pp. G1193-G1201 ◽  
Author(s):  
Naohiro Furukawa ◽  
Hiroyuki Fukuda ◽  
Mizue Hatano ◽  
Tomoshige Koga ◽  
Yasuteru Shiroshita
Keyword(s):  
Receptor Antagonist ◽  
Submandibular Gland ◽  
Nerve Stimulation ◽  
Vagal Stimulation ◽  
Salivary Secretion ◽  
Lingual Nerve ◽  
Afferent Pathway ◽  
Nerve Activity ◽  
Gastric Corpus ◽  
Neurokinin 1

The roles of tachykinin neurokinin-1 (NK1) receptors in the induction of fictive retching, hypersalivation, and gastric responses associated with emesis induced by abdominal vagal stimulation were studied in paralyzed, decerebrated dogs. Vagal stimulation induced gradual increases in salivary secretion and activity of the parasympathetic postganglionic fibers to the submandibular gland, relaxation of the gastric corpus and antrum, and fictive retching. However, hypersalivation and increased nerve activity were suppressed and antral contractility was enhanced during fictive retching. An NK1 receptor antagonist, GR-205171, abolished the enhancement of antral contractility and fictive retching but had no effect on corpus and antral relaxation. Hypersalivation and increased nerve activity were inhibited by GR-205171 but were not completely abolished. Reflex salivation by lingual nerve stimulation was unaffected. These results suggest that GR-205171 acts on the afferent pathway in the bulb and diminishes hypersalivation and antral contraction related to emesis as well as fictive retching but does not affect gastric relaxation or hypersalivation induced by the vagovagal, vagosalivary, and linguosalivary reflexes.

scholarly journals Botulinum toxin A inhibits salivary secretion of rabbit submandibular gland

2013 ◽  
Vol 5 (4) ◽  
pp. 217-223 ◽  
Author(s):  
Xiao-Feng Shan ◽  
Hui Xu ◽  
Zhi-Gang Cai ◽  
Li-Ling Wu ◽  
Guang-Yan Yu
Keyword(s):  
Botulinum Toxin ◽  
Submandibular Gland ◽  
Botulinum Toxin A ◽  
Salivary Secretion ◽  
Toxin A ◽  
Rabbit Submandibular Gland

Salivary secretion in cat submandibular gland mediated by chorda tympani afferents

1995 ◽  
Vol 268 (2) ◽  
pp. R438-R444 ◽  
Author(s):  
H. Izumi ◽  
K. Karita
Keyword(s):  
Submandibular Gland ◽  
Salivary Secretion ◽  
Lingual Nerve ◽  
Prior Treatment ◽  
Chorda Tympani ◽  
Chorda Tympani Nerve ◽  
Autonomic Ganglion ◽  
Blood Flow Increase ◽  
A Site ◽  
Stimulation Of

The aim of the present study was to investigate whether the afferent traffic from the tongue mediated only via the chorda tympani nerve (CTN) can still elicit reflex salivary and vasodilator responses in the cat submandibular gland (SMG) after section of the lingual nerve proper (LNP). Electrical stimulation of the chorda lingual nerve (CLN) at a site approximately 5 mm distal to the intersection of the CLN and the SMG duct elicited salivary and vasodilator responses in the SMG in sympathectomized cats. Both responses were unaffected by section of the LNP. The optimal frequency of CLN stimulation for submandibular salivation and vasodilation was 20 Hz, regardless of whether the LNP had been cut. Prior treatment with the autonomic ganglion blocker hexamethonium (10 mg/kg iv) virtually abolished the salivation and the blood flow increase in SMG. Prior treatment with scopolamine (0.1 mg/kg iv) almost abolished the salivary secretions but had no effect on the vasodilator responses in the SMG elicited by CLN stimulation after LNP section. The mechanism underlying the reflex submandibular salivation mediated by chorda tympani afferents appears to involve parasympathetic muscarinic receptors, but the mechanism for the vasodilator response has yet to be established. These results indicate that afferent traffic passing through the CTN on CLN stimulation is importantly involved in the parasympathetic reflex secretory and vasodilator responses in the cat SMG.

Partial dissociation between salivary secretion and active potassium transport in the perfused cat submandibular gland

1976 ◽  
Vol 364 (2) ◽  
pp. 167-173 ◽  
Author(s):  
Lars Peter Laugesen ◽  
Jens Ole Dich Nielsen ◽  
J�rgen Hedemark Poulsen ◽  
Lene Caroc
Keyword(s):  
Submandibular Gland ◽  
Salivary Secretion ◽  
Potassium Transport ◽  
Partial Dissociation

Structures of nine histamine H2 antagonists related to N-cyano-N'-methyl-N''-[4-(2-pyridyl)butyl]guanidine

1993 ◽  
Vol 49 (3) ◽  
pp. 547-559
Author(s):  
K. Prout ◽  
K. Burns ◽  
D. J. Watkin ◽  
D. G. Cooper ◽  
G. J. Durant ◽  
...  
Keyword(s):  
H2 Antagonists ◽  
Histamine H2 Antagonists

Effects of Phenylephrine on Transplanted Submandibular Gland

2006 ◽  
Vol 85 (12) ◽  
pp. 1106-1111 ◽  
Author(s):  
B. Xiang ◽  
Y. Zhang ◽  
Y.M. Li ◽  
K. Zhang ◽  
Y.Y. Zhang ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Apical Membrane ◽  
Rabbit Model ◽  
Acinar Cells ◽  
Salivary Secretion ◽  
Secretory Function ◽  
Aquaporin 5 ◽  
Receptor Signal ◽  
Wharton’S Duct ◽  
Structural Injury

Autotransplantation of the submandibular gland is a potential treatment for severe kerato-conjunctivitis sicca. However, one of the major barriers to this procedure is that secretions from the transplanted gland decrease shortly after the operation, which may lead to obstruction of Wharton’s duct, or even to transplantation failure. Using a rabbit model, we investigated whether phenylephrine could improve the secretion from the transplanted gland. We found that phenylephrine treatment significantly reversed the decrease in salivary secretion after transplantation, enhanced the expressions of α1A-, α1B-, and α1D-adrenoceptor mRNA, and ameliorated atrophy of acinar cells. Furthermore, phenylephrine also induced translocation of aquaporin-5 from the cytoplasm to the apical membrane, and increased the levels of phospho-ERK1/2, ERK1/2, phospho-PKCζ, and PKCζ in the transplanted gland. These results indicate that phenylephrine treatment moderates structural injury and improves secretory function in the transplanted submandibular gland through promoting α1-adrenoceptor expression and post-receptor signal transduction.

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