Effect of histamine methylation inhibitors on entry of14C-histamine into brain

1978 ◽  
Vol 8 (3) ◽  
pp. 203-205 ◽  
Author(s):  
Margaret A. Reilly ◽  
R. W. Schayer
Keyword(s):  
Histamine Methylation

Anomaly of histamine methylation in endogenous depression

1982 ◽  
Vol 6 (4-6) ◽  
pp. 483-486 ◽  
Author(s):  
Marie-A. Gagne ◽  
Armin Wollin ◽  
Henri Navert ◽  
Gilbert Pinard
Keyword(s):  
Endogenous Depression ◽  
Histamine Methylation

Inhibition of histamine methylation in vivo by the Dimaprit analog, SKF compound 91488

1979 ◽  
Vol 9 (5-6) ◽  
pp. 455-460 ◽  
Author(s):  
Michael A. Beaven ◽  
Richard E. Shaff
Keyword(s):  
Histamine Methylation

scholarly journals Phenylethylamine effects on histamine-induced contraction of isolated guinea-pig trachea rings

2005 ◽  
Vol 24 (2) ◽  
pp. 95-97
Author(s):  
Gvozden Rosic ◽  
Zorica Lazic ◽  
Suzana Pantovic ◽  
Mirko Rosic
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Tone ◽  
Tracheal Smooth Muscle ◽  
Competitive Antagonist ◽  
Methyl Transferase ◽  
Basal Tone ◽  
H3 Receptors ◽  
Isolated Trachea ◽  
Histamine Methylation

Histamine produces constriction of tracheal smooth muscle via H1 receptors, but it also decreases tracheal smooth muscle tone via H2 and H3 receptors. In addition, it has already been reported that phenylethylamine is competitive antagonist of histamine N-methyl-transferase (HMT), enzyme responsible for rapid inactivation of histamine. Our results suggest possibility that phenylethylamine as competitive antagonist of histamine N-methyl-transferase leads to potentiation of histamine induced constriction of isolated guinea-pig trachea, which could be consequence of decreased histamine methylation and subsequent histamine inactivation. At the same time, phenylethylamine had no direct effect on basal tone of intact isolated trachea rings, as well as on other mechanisms leading to increased responsiveness of guinea-pig tracheal smooth muscle (acetylcholine, KCl, electro stimulation).

Histamine methylation in vivo and in vitro

1974 ◽  
Vol 4 (3) ◽  
pp. 185-186 ◽  
Author(s):  
Richard W. Schayer
Keyword(s):  
Histamine Methylation

scholarly journals Inhibitors of Histamine Methylation in Brain Promote Formation of Imidazoleacetic Acid, Which Interacts with GABA Receptors

2002 ◽  
Vol 68 (1) ◽  
pp. 142-151 ◽  
Author(s):  
George D. Prell ◽  
Albert M. Morrishow ◽  
Erwin Duoyon ◽  
Wah S. Lee
Keyword(s):  
Gaba Receptors ◽  
Histamine Methylation

Histamine methylation in schizophrenia

1989 ◽  
Vol 30 (3) ◽  
pp. 167-174 ◽  
Author(s):  
E.P. Heleniak ◽  
D.M. Frechen
Keyword(s):  
Histamine Methylation

Studies on the inhibition of histamine methylation in mice

1973 ◽  
Vol 3 (3) ◽  
pp. 172-173 ◽  
Author(s):  
J. M. Andre ◽  
J. C. Schwartz
Keyword(s):  
Histamine Methylation

Inhibition of histamine methylation in vivo by drugs

1964 ◽  
Vol 13 (3) ◽  
pp. 536-537 ◽  
Author(s):  
Solomon H. Snyder ◽  
Julius Axelrod
Keyword(s):  
Histamine Methylation

Uptake and methylation of histamine by dispersed gastric mucosal cells and its possible influence on acid secretion

1990 ◽  
Vol 68 (1) ◽  
pp. 71-78 ◽  
Author(s):  
A. Wollin
Keyword(s):  
Target Cells ◽  
Gastric Mucosal Cells ◽  
Histamine Concentration ◽  
Mucosal Cells ◽  
Histamine Uptake ◽  
Independent Process ◽  
Methylation Activity ◽  
Product Accumulation ◽  
Uptake And Metabolism ◽  
Histamine Methylation

Inactivation of histamine by gastric mucosal tissue was examined in dispersed rabbit gastric mucosal cells. Mucosal cells were incubated with [14C]histamine. The formed radioactive metabolites were separated and identified by thin layer co-chromatography and quantitated, in both the cellular and extracellular mediums. Gastric mucosal cells internalized histamine, most of which was immediately methylated primarily to Nτ-methylhistamine and released. Cellular histamine product accumulation reached a plateau. The rate of histamine methylation increased with increasing extracellular histamine concentration, moving towards a plateau above 5 μM. Histamine methylation was greatly decreased but not abolished at 4 °C, in the absence of Na+ and by phlorizin (0.5 mM), an inhibitor of Na+-dependent co-transport. Inhibition of histamine N-methyltransferase decreased intracellular methylhistamine content dose dependently without increasing intracellular histamine. The secretagogues pentagastrin and carbachol did not influence histamine metabolism but ethanol inhibited methylation. The data suggest that gastric mucosal cells take up histamine by a Na+-dependent and Na+-independent process. The histamine uptake capacity appears to be linked to the methylation activity within the cell. The decrease in histamine uptake and metabolism caused by ethanol could potentially increase histamine concentrations near the target cells and be the reason for the stimulatory effect of ethanol on acid secretion.Key words: rabbit mucosa, histamine uptake, histamine N-methyltransferase, Nτ-methylhistamine, ethanol.

Comparison of in vitro and in vivo histamine methylation by tissues

1975 ◽  
Vol 5 (2) ◽  
pp. 119-124 ◽  
Author(s):  
R. W. Schayer ◽  
Margaret A. Reilly
Keyword(s):  
Histamine Methylation
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