Emergence during unsuccessful chemotherapy of multiple drug resistance in a strain ofMycobacterium tuberculosis

1992 ◽  
Vol 11 (10) ◽  
pp. 901-907 ◽  
Author(s):  
N. Rastogi ◽  
B. C. Ross ◽  
B. Dwyer ◽  
K. S. Goh ◽  
S. Clavel-Sérès ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Ofmycobacterium Tuberculosis ◽  
Strain Ofmycobacterium

Do Multiple Drug Resistance Transporters Interfere with Cell Functioning under Normal Conditions?

2020 ◽  
Vol 85 (12-13) ◽  
pp. 1560-1569
Author(s):  
D. A. Knorre ◽  
K. V. Galkina ◽  
T. Shirokovskikh ◽  
A. Banerjee ◽  
R. Prasad
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Multiple Drug

scholarly journals Amelioration of the Cost of Conjugative Plasmid Carriage in Eschericha coli K12

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 1641-1649
Author(s):  
Cecilia Dahlberg ◽  
Lin Chao
Keyword(s):  
Drug Resistance ◽  
Multiple Drug Resistance ◽  
Conjugative Plasmid ◽  
Energetic Cost ◽  
Multiple Drug ◽  
Genetic Changes ◽  
Batch Cultures ◽  
Transfer Rates ◽  
Bacterial Plasmid ◽  
The Cost

Abstract Although plasmids can provide beneficial functions to their host bacteria, they might confer a physiological or energetic cost. This study examines how natural selection may reduce the cost of carrying conjugative plasmids with drug-resistance markers in the absence of antibiotic selection. We studied two plasmids, R1 and RP4, both of which carry multiple drug resistance genes and were shown to impose an initial fitness cost on Escherichia coli. To determine if and how the cost could be reduced, we subjected plasmid-containing bacteria to 1100 generations of evolution in batch cultures. Analysis of the evolved populations revealed that plasmid loss never occurred, but that the cost was reduced through genetic changes in both the plasmids and the bacteria. Changes in the plasmids were inferred by the demonstration that evolved plasmids no longer imposed a cost on their hosts when transferred to a plasmid-free clone of the ancestral E. coli. Changes in the bacteria were shown by the lowered cost when the ancestral plasmids were introduced into evolved bacteria that had been cured of their (evolved) plasmids. Additionally, changes in the bacteria were inferred because conjugative transfer rates of evolved R1 plasmids were lower in the evolved host than in the ancestral host. Our results suggest that once a conjugative bacterial plasmid has invaded a bacterial population it will remain even if the original selection is discontinued.

Immunologic responses in Helicobacter-induced inflammatory bowel disease (IBD) in multiple drug resistance (mdria-/-) mice

2001 ◽  
Vol 120 (5) ◽  
pp. A524
Author(s):  
Lillian Maggio-Price ◽  
Donna Shows ◽  
Kim Waggie ◽  
Andrew Burich ◽  
Weiping Zeng ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Drug Resistance ◽  
Bowel Disease ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Inflammatory Bowel
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