Effect of the type of diet on the distribution of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in rat small intestine

1980 ◽  
Vol 36 (12) ◽  
pp. 1399-1400 ◽  
Author(s):  
M. Sugano ◽  
Y. Fujisaki
Keyword(s):  
Small Intestine ◽  
Coenzyme A ◽  
Rat Small Intestine ◽  
Hmg Coa Reductase ◽  
Coa Reductase

scholarly journals Dietary modification of the activation state of intestinal 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase.

1984 ◽  
Vol 48 (11) ◽  
pp. 2745-2751
Author(s):  
Hirosuke OKU ◽  
Akira MORITA ◽  
Takashi IDE ◽  
Michihiro SUGANO
Keyword(s):  
Coenzyme A ◽  
Dietary Modification ◽  
Hmg Coa Reductase ◽  
Coa Reductase

A 68-Year-Old Female with Progressive Pain and Weakness

2016 ◽  
Author(s):  
Jeffrey A. Cohen ◽  
Justin J. Mowchun ◽  
Victoria H. Lawson ◽  
Nathaniel M. Robbins
Keyword(s):  
Creatine Kinase ◽  
Muscle Biopsy ◽  
Creatine Kinase Level ◽  
Coenzyme A ◽  
Inflammatory Myopathy ◽  
Hmg Coa Reductase ◽  
System A ◽  
Coa Reductase ◽  
Cytochrome P 450

Statin myopathy can occur at anytime during use. This chapter discusses an approach to diagnosis, and emphasizes management considerations, including awareness of statin metabolism by the cytochrome P-450 system. A statin must be discontinued in any patient with evidence of myopathy or myalgias. A muscle biopsy should be done in cases that do not improve clinically or by creatine kinase level. It is important to note that there are cases of apparent statin myopathy which transform into a chronic autoimmune inflammatory myopathy. Antibodies to hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase have recently been identified in the majority of patients with autoimmune statin myopathy and this test may give further weight to treat with immunotherapy.

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