Lack of a clinical significant correlation between serum albumin and colloid osmotic pressure

1996 ◽  
Vol 22 (S1) ◽  
pp. S81-S81
Author(s):  
H Delwig ◽  
J C Paling ◽  
J H Zwaveling ◽  
A R J Girbes
Keyword(s):  
Serum Albumin ◽  
Osmotic Pressure ◽  
Colloid Osmotic Pressure

scholarly journals Unexpected Normal Colloid Osmotic Pressure in Clinical States with Low Serum Albumin

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159839 ◽  
Author(s):  
Regina Michelis ◽  
Shifra Sela ◽  
Teuta Zeitun ◽  
Ronit Geron ◽  
Batya Kristal
Keyword(s):  
Serum Albumin ◽  
Osmotic Pressure ◽  
Colloid Osmotic Pressure ◽  
Low Serum

scholarly journals INVESTIGATIONS CONCERNING THE CHANGES IN SERUM PROTEINS DURING IMMUNIZATION

1959 ◽  
Vol 110 (2) ◽  
pp. 259-270 ◽  
Author(s):  
M. Bjørneboe ◽  
Michael Schwartz
Keyword(s):  
Serum Albumin ◽  
Osmotic Pressure ◽  
Plasma Volume ◽  
Pneumococcal Vaccine ◽  
Gamma Globulin ◽  
Serum Proteins ◽  
Colloid Osmotic Pressure ◽  
Significant Alteration ◽  
Regulative Mechanism

On hyperimmunization of rabbits with pneumococcal vaccine, increase in the content of gamma globulin and fall of albumin in the serum are produced. In such hyperimmunized rabbits, investigations of the plasma volume, albumin degradation, and the distribution of the albumin intra- and extravascularly were undertaken by Sterling's method employing rabbit albumin labelled with I131. The investigations do not suggest any significant alteration in the albumin degradation nor in the distribution between the intra- and extravascular albumin. It was demonstrated that the plasma volume increases simultaneously with increase in the gamma globulin and fall in albumin. It is concluded that the fall in serum albumin observed is due to a regulative mechanism which attempts to maintain the colloid-osmotic pressure by increasing the plasma volume.

Albumin Metabolism in Cystic Fibrosis

PEDIATRICS ◽  
1969 ◽  
Vol 44 (1) ◽  
pp. 143-144
Author(s):  
A. Myron Johnson
Keyword(s):  
Cystic Fibrosis ◽  
Serum Albumin ◽  
Osmotic Pressure ◽  
Plasma Volume ◽  
Colloid Osmotic Pressure ◽  
Causal Relationships ◽  
Albumin Synthesis

The study by Strober, Peter, and Schwartz, "Albumin Metabolism in Cystic Fibrosis," demonstrates without question that there is a correlation between serum albumin levels and plasma volume. Causal relationships are more difficult to ascertain, however. It has been well documented that alterations in colloid osmotic pressure result in inverse alteration of albumin synthesis in normovolemic subjects. The previous studies cited by Strober, et al. have all demonstrated, and frequently commented upon, the correlation between hypoalbuminemia in cystic fibrosis patients beyond infancy and elevated levels of immunoglobulins and, when measured, α1- and α2-globulins.

Colloid osmotic pressure changes of dog's blood exposed to different mixtures of CO2 and air

1978 ◽  
Vol 44 (2) ◽  
pp. 254-257 ◽  
Author(s):  
Y. Kakiuchi ◽  
A. B. DuBois ◽  
D. Gorenberg
Keyword(s):  
Red Blood Cells ◽  
Osmotic Pressure ◽  
Cell Volume ◽  
Blood Cells ◽  
Freezing Point ◽  
Colloid Osmotic Pressure ◽  
Red Cell ◽  
Freezing Point Depression ◽  
Pressure Changes ◽  
Different Levels

Hansen's membrane manometer method for measuring plasma colloid osmotic pressure was used to obtain the osmolality changes of dogs breathing different levels of CO2. Osmotic pressure was converted to osmolality by calibration of the manometer with saline and plasma, using freezing point depression osmometry. The addition of 10 vol% of CO2 to tonometered blood caused about a 2.0 mosmol/kg H2O increase of osmolality, or 1.2% increase of red blood cell volume. The swelling of the red blood cells was probably due to osmosis caused by Cl- exchanged for the HCO3- which was produced rapidly by carbonic anhydrase present in the red blood cells. The change in colloid osmotic pressure accompanying a change in co2 tension was measured on blood obtained from dogs breathing different CO2 mixtures. It was approximately 0.14 mosmol/kg H2O per Torr Pco2. The corresponding change in red cell volume could not be calculated from this because water can exchange between the plasma and tissues.

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