The involvement of cyclic 3′, 5′-adenosine monophosphate in the growth hormone release mechanism (s)

1969 ◽  
Vol 25 (7) ◽  
pp. 750-751 ◽  
Author(s):  
E. E. Müller ◽  
A. Pecile ◽  
M. Kabir Naimzada ◽  
Gabriella Ferrario
Keyword(s):  
Growth Hormone ◽  
Adenosine Monophosphate ◽  
Release Mechanism ◽  
Hormone Release ◽  
Growth Hormone Release

Altered release of growth hormone from dispersed adenohypophysial cells of streptozotocin diabetic rats. II. Effects of a phorbol ester and secretagogues which increase cyclic AMP

1989 ◽  
Vol 67 (10) ◽  
pp. 1321-1325
Author(s):  
M. S. Sheppard ◽  
B. A. Eatock ◽  
R. M. Bala
Keyword(s):  
Growth Hormone ◽  
Cyclic Amp ◽  
Phorbol Ester ◽  
Phosphodiesterase Inhibitor ◽  
Adenosine Monophosphate ◽  
Diabetic Rats ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Growth Hormone Releasing Factor ◽  
Streptozotocin Diabetic Rats

We have shown in the companion paper that somatotrophs dispersed from streptozotocin diabetic rats exhibit altered sensitivity to the natural hypothalamic controlling hormones, growth hormone releasing factor and somatostatin. We have further studied the effects on growth hormone release from dispersed adenohypophysial cells of normal and streptozotocin diabetic rats of stimulation by compounds that increase cyclic 3′,5′-adenosine monophosphate formation or inhibit its breakdown and of a phorbol ester. The cells of the diabetic rats had no change in sensitivity in response to either cholera toxin or forskolin. A phosphodiesterase inhibitor caused an equal GH release from cells of both diabetic and normal animals after 60 min of incubation. There was no change in sensitivity of the cells of diabetic animals or in the maximal reponse of these cells to the phorbol ester 12-O-tetradecanoylphorbol 13-acetate when compared with normal cells. A low calcium medium that blocked growth hormone releasing factor stimulated growth hormone release from normal rat cells also blocked it from the cells of the diabetic rats. These results suggest that the defect in response of the somatotrophs of diabetic animals is specific and only occurs with the hypothalamic hormones and not with other secretagogues.Key words: growth hormone, diabetes, streptozotocin, cyclic AMP, phorbol ester.

STUDIES ON THE MECHANISMS OF GROWTH-HORMONE RELEASE INDUCED BY ARGININE USING SYMPATHOLYTIC DRUGS

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S143
Author(s):  
G. Strauch ◽  
E. Modigliani ◽  
H. Bricaire
Keyword(s):  
Growth Hormone ◽  
Hormone Release ◽  
Growth Hormone Release

Central Nervous System and Pituitary Mechanisms in Dopaminergic Stimulation of Growth Hormone Release in Women

1981 ◽  
Vol 32 (4) ◽  
pp. 213-216 ◽  
Author(s):  
Carlo Ferrari ◽  
Roberto Caldara ◽  
Cristiano Barbieri ◽  
Paolo Testori ◽  
Rosanna Benco ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Growth Hormone ◽  
Nervous System ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Dopaminergic Stimulation ◽  
Stimulation Of

Enkephalin-induced growth hormone release in the dog

1980 ◽  
Vol 12 (5) ◽  
pp. 461-465 ◽  
Author(s):  
F. Casanueva ◽  
R. Betti ◽  
D. Vellani ◽  
D. Cocchi ◽  
E.E. Müller
Keyword(s):  
Growth Hormone ◽  
Hormone Release ◽  
Growth Hormone Release

Reliability of Estimates of Pulsatile Characteristics of Luteinizing Hormone and Growth Hormone Release in Women*

1990 ◽  
Vol 71 (6) ◽  
pp. 1646-1652 ◽  
Author(s):  
J. Y. WELTMAN ◽  
J. D. VELDHUIS ◽  
A. WELTMAN ◽  
J. R. KERRIGAN ◽  
W. S. EVANS ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Hormone Release ◽  
Growth Hormone Release
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