Intercellular communication and tissue growth: VII. A cancer cell strain with retarded formation of permeable membrane junction and reduced exchange of a 330-dalton molecule

1976 ◽  
Vol 30 (1) ◽  
pp. 175-186 ◽  
Author(s):  
R. Azarnia ◽  
W. R. Loewenstein
Keyword(s):  
Cancer Cell ◽  
Intercellular Communication ◽  
Tissue Growth ◽  
Cell Strain ◽  
Permeable Membrane

scholarly journals INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

1967 ◽  
Vol 33 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Werner R. Loewenstein ◽  
Richard D. Penn
Keyword(s):  
Intercellular Communication ◽  
Wound Closure ◽  
Cell Movement ◽  
Normal Growth ◽  
Tissue Growth ◽  
Cellular Communication ◽  
Mechanical Contact ◽  
Cell Systems ◽  
Intact State ◽  
Striking Contrast

Intercellular communication was examined in regenerating rat liver and urodele skin, two tissues of fast but normal growth. In both, cellular communication is in general as good as in their respective normal intact state. This stands in striking contrast to the lack of cellular communication in tissues with cancerous growth. Upon wounding of the urodele skin, the normally permeable junctional membranes of cells near the wound border seal themselves off, thereby insulating the interiors of the communicated cell systems from the exterior. When the cells of two opposing borders make mechanical contact in the course of wound closure, communication between them ensues within 30 min. Within this period all cell movement also ceases ("contact inhibition"). The possible implications of these findings in the control of tissue growth are discussed.

Centrosome Proliferation in the Human Androgen-Responsive LNCaP and the Androgen-Independent DU145 Prostate Cancer Cell Lines

1998 ◽  
Vol 4 (S2) ◽  
pp. 1066-1067
Author(s):  
Heide Schatten ◽  
Maureen Ripple ◽  
Ron Balczon ◽  
Meghan Taylor ◽  
Michael Crosser
Keyword(s):  
Prostate Cancer ◽  
Cell Division ◽  
Cell Line ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Line ◽  
Prostate Cancer Cell Line ◽  
Tissue Growth ◽  
Cell Divisions ◽  
Androgen Independent

Cancer is a disease characterized by uncontrolled cell divisions in which the molecular controls for cytoskeletal regulation are bypassed. Cell division is governed by centrosomes, microtubule-organizing cell organelles which are crucial for the organization of the mitotic apparatus during mitosis and cell division. Because centrosome abnormalities are observed in the most common human cancers, we used immunofluorescence and transmission electron microscopy to determine centrosome organization in the human androgenresponsive prostate cancer cell line LNCaP and the androgen-independent prostate cancer cell line DU145. During interphase, centrosomes are located in close vicinity to the outer nuclear membrane, duplicate during S-phase, and become separated to the mitotic poles during the transition from interphase to mitosis. Centrosome regulation is based on a number of different factors which are only partly understood. Hormones play a role during developmental regulation of prostates which might trigger the activation of centrosome proteins and consequent cell divisions in order to ensure tissue growth.

Disruption of gap junctional intercellular communication in human renal cancer cell lines

Urology ◽  
1999 ◽  
Vol 53 (1) ◽  
pp. 218-222 ◽  
Author(s):  
Mitsuru Noguchi ◽  
Koichiro Nomata ◽  
Jun-ichi Watanabe ◽  
Hidesuke Sato ◽  
Hiroshi Kanetake ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Renal Cancer ◽  
Intercellular Communication ◽  
Cancer Cell Lines ◽  
Gap Junctional Intercellular Communication ◽  
Renal Cancer Cell ◽  
Gap Junctional

scholarly journals INTERCELLULAR COMMUNICATION AND TISSUE GROWTH

1968 ◽  
Vol 38 (3) ◽  
pp. 556-561 ◽  
Author(s):  
A. Jamakosmanović ◽  
W. R. Loewenstein
Keyword(s):  
Intercellular Communication ◽  
Tissue Growth ◽  
Membrane Potentials ◽  
Normal Cells ◽  
Thyroid Cancers ◽  
Normal Thyroid

Intercellular communication was examined in normal and cancerous isolated thyroids with an intracellular electrical technique. The cells of normal thyroid (rat, mouse, hamster, man) communicate, within any given follicle, through permeable junctions. The cells of a wide variety of thyroid cancers (rat, hamster) do not communicate to any detectable degree and have resting membrane potentials lower than those of normal cells.

scholarly journals Ouabain Promotes Gap Junctional Intercellular Communication in Cancer Cells

2020 ◽  
Vol 22 (1) ◽  
pp. 358
Author(s):  
Mauricio Serrano-Rubi ◽  
Lidia Jimenez ◽  
Jacqueline Martinez-Rendon ◽  
Marcelino Cereijido ◽  
Arturo Ponce
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Intercellular Communication ◽  
Cancer Cell Lines ◽  
Molecular Structures ◽  
Dye Transfer ◽  
Gap Junctional Intercellular Communication ◽  
Therapeutic Properties ◽  
Gap Junctional

Gap junctions are molecular structures that allow communication between neighboring cells. It has been shown that gap junctional intercellular communication (GJIC) is notoriously reduced in cancer cells compared to their normal counterparts. Ouabain, a plant derived substance, widely known for its therapeutic properties on the heart, has been shown to play a role in several types of cancer, although its mechanism of action is not yet fully understood. Since we have previously shown that ouabain enhances GJIC in epithelial cells (MDCK), here we probed whether ouabain affects GJIC in a variety of cancer cell lines, including cervico-uterine (CasKi, SiHa and Hela), breast (MDA-MB-321 and MCF7), lung (A549), colon (SW480) and pancreas (HPAF-II). For this purpose, we conducted dye transfer assays to measure and compare GJIC in monolayers of cells with and without treatment with ouabain (0.1, 1, 10, 50 and 500 nM). We found that ouabain induces a statistically significant enhancement of GJIC in all of these cancer cell lines, albeit with distinct sensitivity. Additionally, we show that synthesis of new nucleotides or protein subunits is not required, and that Csrc, ErK1/2 and ROCK-Rho mediate the signaling mechanisms. These results may contribute to explaining how ouabain influences cancer.

Intercellular communication and tissue growth

1969 ◽  
Vol 1 (1) ◽  
pp. 274-293 ◽  
Author(s):  
Carmia Borek ◽  
S. Higashino ◽  
W. R. Loewenstein
Keyword(s):  
Intercellular Communication ◽  
Tissue Growth
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