Molecular orbital studies of the action of thyroid hormone analogs: Effects on oxygen consumption of mitochondria and horseradish peroxidase-catalyzed NADH oxidation

1988 ◽  
Vol 16 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Junji Sakurada ◽  
Misako Aida ◽  
Chikayoshi Nagata ◽  
Toichiro Hosoya
Keyword(s):  
Oxygen Consumption ◽  
Thyroid Hormone ◽  
Horseradish Peroxidase ◽  
Molecular Orbital ◽  
Nadh Oxidation ◽  
Hormone Analogs

Molecular orbital studies of thyroid hormone analogs

1973 ◽  
Vol 95 (26) ◽  
pp. 8518-8525 ◽  
Author(s):  
Peter A. Kollman ◽  
Wallace J. Murray ◽  
Merrill E. Nuss ◽  
Eugene C. Jorgensen ◽  
Steve. Rothenberg
Keyword(s):  
Thyroid Hormone ◽  
Molecular Orbital ◽  
Hormone Analogs

ChemInform Abstract: MOLECULAR ORBITAL STUDIES OF THYROID HORMONE ANALOGS

1974 ◽  
Vol 5 (11) ◽  
pp. no-no
Author(s):  
PETER A. KOLLMAN ◽  
WALLACE J. MURRAY ◽  
MERRILL E. NUSS ◽  
EUGENE C. JORGENSEN ◽  
STEVE ROTHENBERG
Keyword(s):  
Thyroid Hormone ◽  
Molecular Orbital ◽  
Hormone Analogs

Body temperature regulation and oxygen consumption in young chicks fed thyroid hormone

1991 ◽  
Vol 69 (7) ◽  
pp. 1842-1847 ◽  
Author(s):  
Gregory K. Snyder ◽  
Joseph R. Coelho ◽  
Dalan R. Jensen
Keyword(s):  
Oxygen Consumption ◽  
Thyroid Hormone ◽  
Body Temperature ◽  
Ambient Temperature ◽  
Cold Exposure ◽  
Elevated Serum ◽  
Body Temperatures ◽  
Serum Thyroid Hormone ◽  
Regulate Body Temperature ◽  
Young Chicks

In chicks the ability to regulate body temperature to adult levels develops during the first 2 weeks of life. We examined whether the ability of young chicks to regulate body temperature is increased by elevated levels of the thyroid hormone 3,3′5-triiodothyronine. By 13 days following hatch, body temperatures of chicks were not significantly different from those expected for adult birds. Furthermore, at an ambient temperature of 10 °C, 13-day-old control chicks were able to maintain body temperature, and elevated serum thyroid hormone levels did not increase rates of oxygen consumption or body temperature above control values. Six-day-old chicks had body temperatures that were significantly lower than those of the 13-day-old chicks and were not able to regulate body temperature when exposed to an ambient temperature of 10 °C. On the other hand, 6-day-old chicks with elevated serum thyroid hormone had significantly higher rates of oxygen consumption than 6-day-old control chicks, and were able to maintain constant body temperatures during cold exposure. The increased oxygen consumption rates and improved ability to regulate body temperature during cold exposure were correlated with increased citrate synthase activity in skeletal muscle. Our results support the argument that thyroid hormones play an important role in the development of thermoregulatory ability in neonate birds by stimulating enzyme activities associated with aerobic metabolism.

scholarly journals Bioactivity of Thyroid Hormone Analogs at Cancer Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Paul J. Davis ◽  
Heng-Yuan Tang ◽  
Aleck Hercbergs ◽  
Hung-Yun Lin ◽  
Kelly A. Keating ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Cancer Cells ◽  
Hormone Analogs

scholarly journals In Vivo Activity of the Thyroid Hormone Receptor β- and α-Selective Agonists GC-24 and CO23 on Rat Liver, Heart, and Brain

Endocrinology ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 1136-1142 ◽  
Author(s):  
Carmen Grijota-Martínez ◽  
Eric Samarut ◽  
Thomas S. Scanlan ◽  
Beatriz Morte ◽  
Juan Bernal
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Target Genes ◽  
Thyroid Hormone Receptor ◽  
Receptor Subtype ◽  
Receptor Subtypes ◽  
Genetic Modifications ◽  
Hormone Analogs ◽  
Thyroid Hormone Receptor Β

Thyroid hormone analogs with selective actions through specific thyroid hormone receptor (TR) subtypes are of great interest. They might offer the possibility of mimicking physiological actions of thyroid hormone with receptor subtype or tissue specificity with therapeutic aims. They are also pharmacological tools to dissect biochemical pathways mediated by specific receptor subtypes, in a complementary way to mouse genetic modifications. In this work, we studied the in vivo activity in developing rats of two thyroid hormone agonists, the TRβ-selective GC-24 and the TRα-selective CO23. Our principal goal was to check whether these compounds were active in the rat brain. Analog activity was assessed by measuring the expression of thyroid hormone target genes in liver, heart, and brain, after administration to hypothyroid rats. GC-24 was very selective for TRβ and lacked activity on the brain. On the other hand, CO23 was active in liver, heart, and brain on genes regulated by either TRα or TRβ. This compound, previously shown to be TRα-selective in tadpoles, displayed no selectivity in the rat in vivo.

scholarly journals THYROID HORMONE TREATMENT AND OXYGEN CONSUMPTION IN EMBRYOS OF THE SPINY DOGFISH

1960 ◽  
Vol 119 (1) ◽  
pp. 109-119 ◽  
Author(s):  
AUSTIN W. PRITCHARD ◽  
AUBREY GORBMAN
Keyword(s):  
Oxygen Consumption ◽  
Thyroid Hormone ◽  
Hormone Treatment ◽  
Spiny Dogfish

Thyroid Hormone, Hormone Analogs, and Angiogenesis

2015 ◽  
pp. 353-362 ◽  
Author(s):  
Paul J. Davis ◽  
Thangirala Sudha ◽  
Hung-Yun Lin ◽  
Shaker A. Mousa
Keyword(s):  
Thyroid Hormone ◽  
Hormone Analogs

Experimental hyperthyroidism in dogs and effect of salivariectomy

1961 ◽  
Vol 201 (4) ◽  
pp. 723-728 ◽  
Author(s):  
Dorothy A. Piatnek ◽  
Robert E. Olson
Keyword(s):  
Heart Rate ◽  
Body Weight ◽  
Oxygen Consumption ◽  
Thyroid Hormone ◽  
Body Temperature ◽  
Caloric Intake ◽  
Clinical Signs ◽  
Turnover Rates ◽  
Laboratory Findings ◽  
Thyroid State

A hyperthyroid state was induced and maintained in 17 dogs for 2–10 months by the administration of massive amounts of thyroid hormone. The great tolerance of this species to such large doses was striking. The clinical signs characteristic of hyperthyroidism in other mammals were observed including significantly increased caloric intake, oxygen consumption, heart rate, and body temperature. The laboratory findings included polycythemia, markedly increased levels of protein-bound iodide (PBI), increased turnover rates of l-thyroxine, and a decreased urinary excretion of inorganic iodide. Unlike other species the hyperthyroid dogs did not demonstrate marked reductions in body weight or serum cholesterol. Salivariectomy neither hastened nor enhanced the onset of exogenous hyperthyroidism in the dog. Measurements of the rate of disappearance of I131 l-thyroxine from the plasma and the rate of appearance of radioactive iodide in the urine indicated that the salivary glands in the intact dog are effective sites of deiodination and iodide excretion. This activity, however, is not the sole regulator of the level of circulating thyroid hormone and thus of the thyroid state.

Kinetic and molecular orbital studies on the rate of oxidation of monosubstituted phenols and anilines by horseradish peroxidase compound II

Biochemistry ◽  
1990 ◽  
Vol 29 (17) ◽  
pp. 4093-4098 ◽  
Author(s):  
Junji Sakurada ◽  
Reiko Sekiguchi ◽  
Koichi Sato ◽  
Toichiro Hosoya
Keyword(s):  
Horseradish Peroxidase ◽  
Molecular Orbital ◽  
Compound Ii

Stimulatory effect of DIMBOA on NADH oxidation catalysed by horseradish peroxidase

1997 ◽  
Vol 46 (1) ◽  
pp. 11-15 ◽  
Author(s):  
M.Cecilia Rojas G ◽  
Francisco Pérez ◽  
Luis González
Keyword(s):  
Horseradish Peroxidase ◽  
Nadh Oxidation
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