Influence of a continuous intragastric and intravenous infusion of somatostatin on stimulated gastric secretion

1983 ◽  
Vol 183 (2) ◽  
pp. 153-156
Author(s):  
B. Limberg ◽  
B. Kommerell
Keyword(s):  
Gastric Secretion ◽  
Intravenous Infusion

Duodenogastric reflux in the dog

1982 ◽  
Vol 242 (6) ◽  
pp. G603-G607
Author(s):  
A. Sonnenberg ◽  
S. A. Muller-Lissner ◽  
G. Schattenmann ◽  
J. R. Siewert ◽  
A. L. Blum
Keyword(s):  
Gastric Emptying ◽  
Gastric Secretion ◽  
Intravenous Infusion ◽  
Duodenogastric Reflux ◽  
Gastric Volume ◽  
Gastric Digestion ◽  
Protein Meal ◽  
Gastric Emptying Rate

Duodenogastric reflux, gastric emptying, and gastric secretion were measured simultaneously by a double-marker technique after instillation of a liquid lipid meal (300 ml Intralipid) or a protein meal (300 ml Bactopeptone) in five trained mongrel dogs. A lipid meal was emptied slower and elicited less volume secretion than a protein meal. Duodenogastric reflux rate and intragastric accumulation of duodenal contents were similar with both meals. Intravenous infusion of atropine slowed gastric emptying and inhibited gastric volume secretion only in the case of protein meal. Atropine increased duodenogastric reflux rate and gastric accumulation of duodenal contents with both protein and lipid meals. The percentage of duodenal contents inside the stomach increased continuously during gastric emptying; it did not exceed 20% with both meals given alone and 40% with both meals given together with atropine. It is concluded that duodenogastric reflux and gastric accumulation of duodenal contents are common phenomena during gastric digestion of a meal. The degree of such accumulation does not depend on the type of meal. Intragastric accumulation of duodenal contents is increased when duodenogastric reflux rate is stimulated and when gastric emptying rate is inhibited simultaneously.

Water drinking induced by gastric secretagogues in pigs

1986 ◽  
Vol 251 (1) ◽  
pp. R157-R164
Author(s):  
T. R. Houpt ◽  
L. C. Weixler ◽  
D. W. Troy
Keyword(s):  
Gastric Secretion ◽  
Intravenous Infusion ◽  
Test Period ◽  
Continuous Intravenous Infusion ◽  
Dose Rates ◽  
Water Drinking ◽  
Young Pigs ◽  
Drinking Response ◽  
Stimulation Of

Eleven young pigs, feeding and drinking operantly, were tested for drinking responses to three gastric secretagogues. First, feed was removed for 1 h before the test period, then a continuous intravenous infusion of saline or a secretagogue was begun at a priming rate of 0.6 ml/min for the first 10 min, then at 0.3 ml/min for 50 min. Dose rates were the smallest that would still cause a vigorous gastric secretion. When 0.9% NaCl was infused, the pigs drank a mean of 54 +/- 11 (SE) ml. The comparable volumes for the secretagogues were histamine 174 +/- 41 ml (1 microgram . kg-1 . min-1); pentagastrin 231 +/- 38 ml (0.5 microgram . kg-1 . min-1); and bethanechol 231 +/- 35 ml (1.0-1.5 microgram . kg-1 . min-1). Pretreatment with cimetidine (300 mg iv) depressed the drinking response to histamine to 30 +/- 10 ml and to pentagastrin to 58 +/- 24 ml. Atropine (2 mg iv) depressed the response to bethanechol to 28 +/- 16 ml. Differences between responses to the secretagogues and either control drinking or antagonist-blocked responses were all significant (P less than 0.001). The results indicate that gastric secretion could play a role in stimulation of preprandial water drinking.

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