Cardiac asthma presenting as status asthmaticus: Deleterious effect of epinephrine therapy

The deleterious effect of post mortem degeneration results in a progressive loss of ultrastructural detail. This had led to reluctance (if not refusal) to examine autopsy material by means of transmission electron microscopy. Nevertheless, Johannesen has drawn attention to the fact that a sufficient amount of significant features may be preserved in order to enable the establishment of a definitive diagnosis, even on “graveyard” tissue.Routine histopathology of the autopsy organs of a woman of 78 showed the presence of a well circumscribed adenoma in the anterior lobe of the pituitary. The lesion came into close apposition to the pars intermedia. Its architecture was more compact and less vascular than that of the anterior lobe. However, there was some grouping of the cells in relation to blood vessels. The cells tended to be smaller, with a higher nucleocytoplasmic ratio. The cytoplasm showed a paucity of granules. In some of the cells, it was eosinophilic.

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Cognitive Load Mediates the Effect of Emotion on Analytical Thinking

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000333 ◽

2016 ◽

Vol 63 (6) ◽

pp. 343-350 ◽

Cited By ~ 5

Author(s):

Bastien Trémolière ◽

Marie-Ève Gagnon ◽

Isabelle Blanchette

Keyword(s):

Cognitive Load ◽

Secondary Task ◽

Deleterious Effect ◽

Detrimental Effect ◽

Emotional Problems ◽

Syllogistic Reasoning ◽

Cognitive Resources ◽

Potential Explanation ◽

Cognitive Mechanism ◽

Analytical Thinking

Abstract. Although the detrimental effect of emotion on reasoning has been evidenced many times, the cognitive mechanism underlying this effect remains unclear. In the present paper, we explore the cognitive load hypothesis as a potential explanation. In an experiment, participants solved syllogistic reasoning problems with either neutral or emotional contents. Participants were also presented with a secondary task, for which the difficult version requires the mobilization of cognitive resources to be correctly solved. Participants performed overall worse and took longer on emotional problems than on neutral problems. Performance on the secondary task, in the difficult version, was poorer when participants were reasoning about emotional, compared to neutral contents, consistent with the idea that processing emotion requires more cognitive resources. Taken together, the findings afford evidence that the deleterious effect of emotion on reasoning is mediated by cognitive load.

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Schwerer Asthmaanfall und Status asthmaticus im Kindesalter

Kinder- und Jugendmedizin ◽

10.1055/s-0037-1617844 ◽

2005 ◽

Vol 05 (01) ◽

pp. 11-15

Author(s):

Nikolaus Schwerk ◽

Werner Siekmeyer ◽

Lars Vogler

Keyword(s):

Asthma Bronchiale ◽

Status Asthmaticus ◽

Chronische Erkrankung ◽

Schwerer Asthmaanfall ◽

Diagnostische Möglichkeiten

ZusammenfassungAsthma bronchiale stellt in Deutschland die häufigste chronische Erkrankung bei Kindern dar. 10% aller Kinder in Deutschland sind betroffen. Von diesen leiden 5% an einem schweren persistierenden Asthma bronchiale. Die Prävalenz hat in den letzten Jahren erheblich zugenommen und die Tendenz ist weiter steigend. Trotz deutlicher Fortschritte in der Therapie hat die Zahl schwerer Asthmaanfälle nicht abgenommen. Die Therapie des Status asthmaticus umfasst den intensiven Einsatz von inhalativen oder systemischen Sympathomimetika (β-adrenoceptoren-Agonisten), inhalativen Anticholinergika sowie antiinflammatorisch wirksamen Kortikosteroiden. Die Indikation zur Beatmung sollte zurückhaltend gestellt werden und nur Extremfällen vorbehalten sein. In dieser Arbeit sollen diagnostische Möglichkeiten und therapeutische Mittel aktuell dargestellt werden.

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Inhibition by Phenol and Phenolic Acids of Platelet Release Reaction

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649082 ◽

1973 ◽

Vol 30 (02) ◽

pp. 334-338 ◽

Cited By ~ 1

Author(s):

Felisa C. Molinas

Keyword(s):

Renal Failure ◽

Phenolic Compounds ◽

Phenolic Acids ◽

Platelet Function ◽

Deleterious Effect ◽

Release Reaction ◽

Contributory Factors ◽

Adp Release ◽

Platelet Release

SummaryIt has been postulated that the high phenol and phenolic acids plasmatic levels found in patients with chronic renal failure are contributory factors in the abnormal platelet function described in these patients. This hypothesis was corroborated by “in vitro” studies showing the deleterious effect of these compounds on certain platelet function after pre-incubation of PRP with phenol and phenolic compounds. The present studies were conducted to determine the influence of phenolic compounds on platelet release reaction. It was found that phenol inhibited from 62.5 to 100% the effect of the aggregating agents thrombin, adrenaline and ADP on platelet 5-HT-14C release. The phenolic acids p-, m-, and o-HPAA inhibited from 36.35 to 94.8% adrenaline and ADP-induced platelet 5-HT-14C release. Adrenaline-induced platelet ADP release was inhibited from 27.45 to 38.10% by the phenolic compounds. These findings confirm the hypothesis that phenolic compounds interfere with platelet function through the inhibition of the release reaction.

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