Increased plasma tele-methylhistamine levels in the rat: Effects on plasma and tissue histamine and its elimination

1995 ◽  
Vol 44 (S1) ◽  
pp. S88-S89
Author(s):  
T. Irman-Florjanc
Keyword(s):  
Tissue Histamine

Distribution oand pharmacological release of histamine in canine lung in vivo

1978 ◽  
Vol 44 (3) ◽  
pp. 455-463 ◽  
Author(s):  
M. R. Nisam ◽  
A. Zbinden ◽  
S. Chesrown ◽  
D. Barnett ◽  
W. M. Gold
Keyword(s):  
Lung Parenchyma ◽  
Smooth Muscle Contraction ◽  
Lung Compliance ◽  
Internal Diameter ◽  
Cellular Interactions ◽  
Arterial Blood ◽  
Beta Adrenergic Agonists ◽  
Anesthetized Dogs ◽  
Tissue Histamine

We have examined the physiological effects of stored mediators released from airways by compound 48/80 aerosols in anesthetized dogs. In 13 dogs, both mast cell numbers and tissue histamine were related inversely to bronchial internal diameter (P less than 0.0001). Compound 48/80 aerosols degranulated mast cells and decreased histamine content (-29.0 +/- 10.0%; mean +/- SE) in 5–10 mm bronchi, but not in 3–4 mm bronchi or lung parenchyma. This was associated with increased plasma histamine (31.8 +/- 18.4 ng/ml), increased airflow resistance (Rrs: + 452 +/- 257%), decreased lung compliance (-28 +/- 10%), and decreased arterial blood pressure (-41 +/- 6.5%) at 2 min. The increased Rrs was reversed by beta-adrenergic agonists, indicating it was caused by bronchial smooth muscle contraction; prevented by chlorpheniramine, indicating it was caused by histamine action on H1-receptors; and augmented and prolonged by propranolol, suggesting that histamine triggered sympathetic mechanisms which modulated the effect of 48/80. This experimental approach permits the study of mechanisms in vivo which may be involved in the sequence of reactions initiated by antigen-IgE interaction. However, the latter involve not only stored mediators, but also unstored mediators, neural reflexes, and complex cellular interactions.

IgE-mediated hypersensitivity in human heart !tissue: Histamine release and functional c,hanges

1986 ◽  
Vol 77 (5) ◽  
pp. 709-714 ◽  
Author(s):  
L GRAVER ◽  
D ROBERTSON ◽  
R LEVI ◽  
C BECKER ◽  
B WEKSLER ◽  
...  
Keyword(s):  
Histamine Release ◽  
Human Heart ◽  
Heart Tissue ◽  
Ige Mediated ◽  
Tissue Histamine ◽  
Human Heart Tissue

Effects of Naja nigricollis venom on blood and tissue histamine

Toxicon ◽  
1971 ◽  
Vol 9 (2) ◽  
pp. 169-172 ◽  
Author(s):  
A.H. Mohamed ◽  
M.S. El-Serougi ◽  
R.M. Hamed
Keyword(s):  
Tissue Histamine
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