Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations

1983 ◽  
Vol 39 (11) ◽  
pp. 1303-1305 ◽  
Author(s):  
M. Bouclier ◽  
M. J. Jung ◽  
F. Gerhart
Keyword(s):  
Histidine Decarboxylase ◽  
Tissue Histamine

scholarly journals Regulation of human L-histidine decarboxylase gene expression

1996 ◽  
Vol 71 ◽  
pp. 331
Author(s):  
Atsuo Kuramasu ◽  
Hiroshi Ohtsu ◽  
Takehiko Watanabe
Keyword(s):  
Gene Expression ◽  
Histidine Decarboxylase

Effects of phorbol ester and dexamethasone treatment on histidine decarboxylase and ornithine decarboxylase in basophilic cells

2001 ◽  
Vol 61 (9) ◽  
pp. 1101-1106 ◽  
Author(s):  
Ignacio Fajardo ◽  
Jose L Urdiales ◽  
Miguel A Medina ◽  
Francisca Sanchez-Jimenez
Keyword(s):  
Ornithine Decarboxylase ◽  
Phorbol Ester ◽  
Histidine Decarboxylase ◽  
Dexamethasone Treatment

Expression of histidine decarboxylase in melanocytes of the human skin

2021 ◽  
Vol 535 ◽  
pp. 19-24
Author(s):  
Yoshihiro Inami ◽  
Miki Fukushima ◽  
Hiroyuki Murota
Keyword(s):  
Human Skin ◽  
Histidine Decarboxylase

scholarly journals Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 555
Author(s):  
Barbara Rani ◽  
Bruna Silva-Marques ◽  
Rob Leurs ◽  
Maria Beatrice Passani ◽  
Patrizio Blandina ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Histamine Release ◽  
Histidine Decarboxylase ◽  
Acetylcholinesterase Inhibitor ◽  
Social Recognition ◽  
Amnesic Effect ◽  
Brain Histamine ◽  
Monogamous Species ◽  
Social Recognition Memory

The ability of recognizing familiar conspecifics is essential for many forms of social interaction including reproduction, establishment of dominance hierarchies, and pair bond formation in monogamous species. Many hormones and neurotransmitters have been suggested to play key roles in social discrimination. Here we demonstrate that disruption or potentiation of histaminergic neurotransmission differentially affects short (STM) and long-term (LTM) social recognition memory. Impairments of LTM, but not STM, were observed in histamine-deprived animals, either chronically (Hdc−/− mice lacking the histamine-synthesizing enzyme histidine decarboxylase) or acutely (mice treated with the HDC irreversible inhibitor α-fluoromethylhistidine). On the contrary, restriction of histamine release induced by stimulation of the H3R agonist (VUF16839) impaired both STM and LTM. H3R agonism-induced amnesic effect was prevented by pre-treatment with donepezil, an acetylcholinesterase inhibitor. The blockade of the H3R with ciproxifan, which in turn augmented histamine release, resulted in a procognitive effect. In keeping with this hypothesis, the procognitive effect of ciproxifan was absent in both Hdc−/− and αFMH-treated mice. Our results suggest that brain histamine is essential for the consolidation of LTM but not STM in the social recognition test. STM impairments observed after H3R stimulation are probably related to their function as heteroreceptors on cholinergic neurons.

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